Is Cirrhosis Protective for Venous Thromboembolism? Analysis From a National Inpatient Sample

Kumar, Gagan; Kumar, Nilay; Deshmukh, Abhishek; Sakhuja, Ankit; Taneja, Amit; Padala, Kiran; Datta, Mohit; Markan, Sandeep; Nanchal, Rahul

doi:10.1378/chest.9844

Cited by 4 publications

(3 citation statements)

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“…After screening of titles and abstracts, 84 studies were selected for further search, 29 studies [3,12,14,17,[21][22][23][24][25][26][27][28][29][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59] reporting incidence or prevalence of VTE in CLD were included (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Incidence and prevalence of venous thromboembolism in chronic liver disease: A systematic review and meta-analysis

Subhani

Sheth

Ahmed

et al. 2022

Thrombosis Research

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Section: Resultsmentioning

confidence: 99%

“…Thirteen studies reported period prevalence per year [12,14,22,23,26,28,29,[48][49][50]55,56,59], comprising a total of 17,533,466 hospitalised CLD patients had 134,646 pre-existing VTE events. Period prevalence of VTE in CLD varied from 0.33% (95% CI 0.23, 0.46) to 4.69% (95% CI 2.45, 8.04) per year.…”

Section: Prevalencementioning

confidence: 99%

Incidence and prevalence of venous thromboembolism in chronic liver disease: A systematic review and meta-analysis

Subhani

Sheth

Ahmed

et al. 2022

Thrombosis Research

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“…20 Delay in diagnosis and treatment of PE is associated with increased mortality and lower quality of life, 21 especially in patients with CKD. 22 Few studies, however, have focused on patients with suspected PE, [23][24][25] who not only require rapid diagnosis but also frequently have significant disease burden that may raise concern over precipitating AKI. In the current study, we aimed to assess the risk of AKI following CM exposure from CTPA compared with a control group who underwent V/Q scintigraphy.…”

Section: Introductionmentioning

confidence: 99%

Risk of Acute Kidney Injury after Intravenous Contrast Media Administration in Patients with Suspected Pulmonary Embolism: A Propensity-Matched Study

Elias

Aronson

2020

Thromb Haemost

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Background Although computed tomography pulmonary angiography (CTPA) is the preferred diagnostic procedure in patients with suspected pulmonary embolism (PE), some patients undergo ventilation/perfusion (V/Q) lung scan due to concern of contrast-associated acute kidney injury (AKI). Methods The study used a cohort of 4,565 patients with suspected PE. Patients who received contrast during CTPA were compared with propensity score-matched unexposed control patients who underwent V/Q lung scanning. AKI was defined as ≥50% increase in serum creatinine during the first 72 hours after either CTPA or V/Q lung scan. Results Classification and regression tree analysis demonstrated that baseline creatinine was the strongest determinant of the decision to use CTPA. Propensity-score matching yielded 969 patient pairs. There were 44 AKI events (4.5%) in patients exposed to contrast media (CM) and 33 events (3.4%) in patients not exposed to CM (risk difference: 1.1%, 95% confidence interval [CI]: −0.6 to 2.9%; odds ratio [OR]: 1.39, 95% CI: 0.86–2.26; p = 0.18). Using different definitions for AKI and extending the time window for AKI diagnosis gave similar results. In a sensitivity analysis with the inverse probability weighting method, the OR for AKI in the CTPA versus V/Q scan was 1.14 (95% CI: 0.72–1.78; p = 0.58). Conclusion Intravenous contrast material administration was not associated with an increased risk of AKI in patients with suspected PE. Given the diagnostic superiority of CTPA, these results are reassuring with regard to the use of CTPE in patients with suspected PE perceived to be at risk for AKI.

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Epidemiology of venous thromboembolism in patients with liver diseases: a systematic review and meta-analysis

Ren

Guo

et al. 2014

Intern Emerg Med

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The risk of venous thromboembolism (VTE) may be increased in patients with liver diseases. A systematic review and meta-analysis were conducted to analyze the epidemiology of VTE in such patients. All relevant studies were searched via the PubMed, EMBASE, and Cochrane Library databases. The incidence and prevalence of VTE were pooled using random-effect models. Subgroup analyses were conducted according to the type of VTE [deep vein thrombosis (DVT), pulmonary embolism (PE)], type of liver disease (liver cirrhosis alone/unclassified liver diseases or non-cirrhotics), region in which the study was performed (USA/Europe/Asia), number of total observed patients with liver diseases (>1,000/<1,000 patients), study quality (high/low), and methods for identifying the cases (ICD codes/clinical charts). Of 4,843 papers initially identified, 20 were included. The incidence of VTE varied from 0.33 to 6.32 % in 14 studies with a pooled value of 1 % (95 % confidence interval (CI) 0.7-1.3 %). The pooled incidence of DVT and PE was 0.6 % (95 % CI 0.4-0.8 %) and 0.28 % (95 % CI 0.13-0.49 %), respectively. The prevalence of VTE varied from 0.6 to 4.69 % in six studies with a pooled value of 1.0 % (95 % CI 0.7-1.2 %). The pooled prevalence of DVT and PE was 0.7 % (95 % CI 0.6-0.9 %) and 0.36 % (95 % CI 0.13-0.7 %), respectively. The heterogeneity was statistically significant in the main and subgroup meta-analyses. In conclusion, about 1 % of patients with liver diseases develop or are diagnosed with VTE during their hospitalizations. However, the epidemiological data are very heterogeneous among studies.

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Is Cirrhosis Protective for Venous Thromboembolism? Analysis From a National Inpatient Sample

Cited by 4 publications

References 0 publications

Incidence and prevalence of venous thromboembolism in chronic liver disease: A systematic review and meta-analysis

Incidence and prevalence of venous thromboembolism in chronic liver disease: A systematic review and meta-analysis

Risk of Acute Kidney Injury after Intravenous Contrast Media Administration in Patients with Suspected Pulmonary Embolism: A Propensity-Matched Study

Epidemiology of venous thromboembolism in patients with liver diseases: a systematic review and meta-analysis

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