Is chronic urticaria more than skin deep?

Kocatürk, Emek; Grattan, Clive

doi:10.1186/s13601-019-0287-2

Cited by 18 publications

(12 citation statements)

References 47 publications

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“…It has also been a matter of curiosity whether these existing pathologies are only characterized by the skin. It has been reported that systemic effects due to increased plasma histamine levels in patients with CSU can also be observed (17). Headache, increased gastric acid secretion, tachycardia, decreased arterial pressure, and bronchospasm has been reported as other systemic findings that may occur in CSU (18).…”

Section: Resultsmentioning

confidence: 99%

Choroidal thickness and retinal nerve fiber layer analysis in chronic spontaneous urticaria

Zor

Biçer

Yıldız

2022

Journal of Health Sciences and Medicine

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Aim: In this study, we investigated the effects of chronic spontaneous urticaria on the choroid and retinal nerve fiber layer. Material and Method: The patient group consisted of newly diagnosed 54 chronic spontaneous urticaria (CSU ) patient and the control group consisted of 54 healthy volunteer. Choroidal and retinal nerve fiber layer (RNFL) thickness measurements were performed with Cirrus HD-OCT (Carl Zeiss Meditec Inc., Dublin, CA, USA) 30 minutes after pupil dilation with 0,5% tropicamide. Results: In the patient group, nasal choroidal thickness (NCT) was 290.11±43.16 μm, subfoveal choroidal thickness (SFCT) was 339.17±37.709 μm, temporal choroidal thickness (TCT) was 296.00±42.859 μm, mean choroidal thickness (MCT) was 308.33±35.923 μm and RNFL thickness was 91.11±7.393 μm. NCT was 248.42±35,742 μm, SFCT 276.56±40.04 μm, TCT 253.69±37.384 μm, MCT 259.50±32,986 μm and RNFL thickness 92.19±8.719 μm in the control group. When we examine the p value, it is seen that both groups are similar to each other in terms of RNFL thickness (p=0.326), while there is a significant thickening in all choroidal regions of patients with CSU, including NCT, SFCT, TCT, MCT (p=0.000, p=0.000, p=0.000, p=0.000, respectively). Conclusion: The choroid is affected in CSU and choroidal thickness can be a noninvasive method that can be used in diagnosis CSU. However, studies of longer disease durations may provide more illuminating information about CSU and choroid and RNFL.

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Section: Resultsmentioning

confidence: 99%

Choroidal thickness and retinal nerve fiber layer analysis in chronic spontaneous urticaria

Zor

Biçer

Yıldız

2022

Journal of Health Sciences and Medicine

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“…[9] There are certain comorbidities, frequently associated with urticaria: Autoimmunity, infections, allergy, emotional stress, and metabolic syndrome with dietary factors that can aggravate chronic urticaria (CU). [1,2,[10][11][12][13][14][15][16][17][18][19] Some patients have more than one concomitant disease. These patients are older, have longer duration of urticaria, and are more resistant to antihistamines.…”

Section: Indian Journal Of Skin Allergymentioning

confidence: 99%

Urticaria and comorbidities

Gotua

Agondi

Chérrez-Ojeda

2022

IJSA

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Urticaria is a mast cell (MC)-driven skin disease. Degranulation of these cells is triggered by the activation of several receptors on its surface. The activation of MC in chronic spontaneous urticaria (CSU) appears to be associated with an autoimmune etiology. Certain comorbidities such as autoimmunity, infections, allergy, emotional stress, and metabolic syndrome are frequently associated with chronic urticaria (CU). The objective of this review is to highlight the frequent association between CU and several comorbidities, which can lead to a worse prognosis for the underlying disease. We searched for original and review articles on CU and comorbidities in PUBMED, abstracts published in AAAAI and EAACI; all of them in English. Our review reinforced how CSU, being itself an autoimmune disease, is strongly linked to several other autoimmune diseases. Besides autoimmunity, emotional stress was considered another frequent comorbidity associated with CU and also a trigger factor for urticaria exacerbation. Some studies recently considered CU as a low-grade chronic inflammatory condition and may be associated with metabolic syndrome. In conclusion, CU is considered a heterogeneous disease with distinct clinical features. It is worth remembering that CU should not be considered just a skin disease and its complete control could minimize a worse clinical outcome.

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“…Redness, swelling, and itch result from the degranulation of cutaneous or submucosal mast cells with the release of pre-formed and newly synthesized mediators, including histamine and cysteinyl leukotrienes LTC4, D4, and E4. Several pathogenetic mechanisms, including the dysregulation of intracellular signaling pathways in basophils and mast cells, an abnormal innate immunity response, and the simultaneous activation of inflammatory response and coagulation system, are involved [59,60]. In the active phase of CU, especially in the spontaneous form, increased circulating levels of inflammatory markers including interleukin IL-6, fibrin degradation products, D-dimer, and C-reactive protein (CRP) are found [61].…”

Section: Urticariamentioning

confidence: 99%

Osteoporosis in Skin Diseases

Sirufo

Pietro

Bassino

et al. 2020

IJMS

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Osteoporosis (OP) is defined as a generalized skeletal disease characterized by low bone mass and an alteration of the microarchitecture that lead to an increase in bone fragility and, therefore, an increased risk of fractures. It must be considered today as a true public health problem and the most widespread metabolic bone disease that affects more than 200 million people worldwide. Under physiological conditions, there is a balance between bone formation and bone resorption necessary for skeletal homeostasis. In pathological situations, this balance is altered in favor of osteoclast (OC)-mediated bone resorption. During chronic inflammation, the balance between bone formation and bone resorption may be considerably affected, contributing to a net prevalence of osteoclastogenesis. Skin diseases are the fourth cause of human disease in the world, affecting approximately one third of the world’s population with a prevalence in elderly men. Inflammation and the various associated cytokine patterns are the basis of both osteoporosis and most skin pathologies. Moreover, dermatological patients also undergo local or systemic treatments with glucocorticoids and immunosuppressants that could increase the risk of osteoporosis. Therefore, particular attention should be paid to bone health in these patients. The purpose of the present review is to take stock of the knowledge in this still quite unexplored field, despite the frequency of such conditions in clinical practice.

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Is chronic urticaria more than skin deep?

Cited by 18 publications

References 47 publications

Choroidal thickness and retinal nerve fiber layer analysis in chronic spontaneous urticaria

Choroidal thickness and retinal nerve fiber layer analysis in chronic spontaneous urticaria

Urticaria and comorbidities

Osteoporosis in Skin Diseases

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