Is chronic hepatitis B infection a protective factor for the progression of advanced pancreatic ductal adenocarcinoma? An analysis from a large multicenter cohort study

Chen, Qiwen; Ning, Zhouyu; Wang, Lei; Hui, Ying; Dong, Shu; Zhang, Chenyue; Shen, Xing; Guo, Yuanbiao; Chen, Hao; Zhu, Xiaoyan; Shen, Yehua; Shi, Weidong; Hua, Yi-Jun; Wang, Kun; Lin, Jiahao; Xu, Litao; Chen, Lianyu; Feng, Long-Hai; Zhang, Xiumei; Xie, Jing; Sun, Bo; Sun, Yunbo; Gu, Wenchao; Kang, Mei; Tang, Zheng; Chen, Zhujun; Chen, Zhe; Liu, Luming; Yu, Jinming; Li, Zhao‐Shen; Meng, Zhiqiang

doi:10.18632/oncotarget.13000

Cited by 3 publications

(2 citation statements)

References 38 publications

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“…It has been reported that HBV infection status is closely associated with liver metastases of malignancies. In a previous study, Chen et al examined four types of HBV infection status and found that chronic HBV infection decreased the risk of liver metastases in patients with advanced pancreatic ductal adenocarcinoma ( 13 ). Qiu et al described that the occurrence of liver metastasis of colorectal cancer was significantly lower in the chronic HBV infection group (HR: 0.29, 95% CI: 0.12–0.72, P<0.01), inactive carrier group (HR: 0.36, 95% CI: 0.22–0.59, P<0.01) and resolved HBV infection group (HR: 0.63, 95% CI: 0.46–0.85, P<0.01) than in the non-infection group ( 14 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of hepatitis B virus infection status on liver metastasis of nasopharyngeal carcinoma: a cohort study

Chen

et al. 2019

Transl. Cancer Res

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Background The impact of hepatitis B virus (HBV) infection status on liver metastasis of nasopharyngeal carcinoma (NPC) has not been thoroughly elucidated to date. This study aimed to determine how HBV infection status influences liver metastasis of NPC through the analysis of clinical samples. Methods A total of 1,367 patients with pathologically diagnosed NPC who received systemic treatment at Nanfang Hospital or Zhujiang Hospital between January 2005 and December 2015 were enrolled in this retrospective study. Based on their HBV infection status, these patients were separated into four groups: negative infection (n=492), chronic HBV infection (n=123), inactive HBV carrier (n=175), and resolved HBV infection (n=577). The relationship between HBV infection status and liver metastasis of NPC was examined. Results Compared with the negative infection group, we observed that an inactive HBV carrier status was related to liver metastasis in patients with NPC (HR: 0.392; 95% CI: 0.178–0.863; P=0.020). The resolved HBV infection group had a lower risk of liver metastasis than the negative infection group (HR: 0.621; 95% CI: 0.402–0.959; P=0.032). There was no direct association between HBV infection status and distant metastasis of NPC. Conclusions Inactive HBV infections and resolved HBV infections are highly associated with a decreased risk of liver metastases in NPC patients compared with patients without HBV infections.

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Section: Discussionmentioning

confidence: 99%

Effect of hepatitis B virus infection status on liver metastasis of nasopharyngeal carcinoma: a cohort study

Chen

et al. 2019

Transl. Cancer Res

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“…In a study conducted in China, chronic active infection with HBV was associated with statistically significant decreased rates of synchronous and metachronous metastases in patients with advanced PDAC and improved survivals for patients with stage IV PDAC, compared with patients with no HBV infection (70,71). No differences were observed for inactive carriers (70). This observation is reminiscent of the fact that lower rates of liver metastases of colorectal cancer origin in patients with chronic liver diseases were previously highlighted in a meta-analysis (66).…”

Section: Is There Any Influence Of Hbv Infection On Clinico-pathologimentioning

confidence: 99%

Is Hepatitis B Virus a Player in Pancreatic Cancer?

Dumitraşcu¹,

Pineau²

2018

chr

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Pancreatic cancer (i.e., pancreatic ductal adenocarcinoma, PDAC) is an important healthcare issue and a highly lethal disease. Thus, almost 80% of patients with PDAC will die within one year after diagnosis. Several factors including smoking, obesity, advanced age, diabetes mellitus and chronic pancreatitis have been associated with increased risk of PDAC. Hepatitis B virus (HBV) infection is also considered as a risk factor for PDAC development in some studies. However, the role of HBV infection in PDAC is poorly explored. The present paper reviews the current relevant literature exploring the impact of HBV infection in PDAC. Assessment of HBV infection impact in PDAC is challenging because its effects could be easily underestimated. Indeed, the role played by occult B infection (OBI) and intrinsic difficulties to detect HBV antigens or DNA in pancreatic tissue remains major limitations to further progress. To date a significant proportion of available literature suggests the potential oncogenic role of HBV in PDAC but experimental evidences remain scarce. Remarkably, it appears that HBV infection might influence some clinical and pathological features of patients with PDAC. Future researches to better define the role of HBV infection in developing PDAC are urgently needed.

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Development and Validation of a Nomogram for Predicting Survival in Patients with Advanced Pancreatic Ductal Adenocarcinoma

Deng

Dong

Wang

et al. 2017

Sci Rep

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This study aimed to develop and validate an effective prognostic nomogram for advanced PDAC patients. We conducted a prospective multicenter cohort study involving 1,526 advanced PDAC patients from three participating hospitals in China between January 1, 2004 and December 31, 2013. Two thirds of the patients were randomly assigned to the training set (n = 1,017), and one third were assigned to the validation set (n = 509). Multivariate cox regression analysis was performed to identify significant prognostic factors for overall survival to develop the nomogram. Internal and external validation using C-index and calibration curve were conducted in the training set and validation set respectively. As results, seven independent prognostic factors were identified: age, tumor stage, tumor size, ALT (alanine aminotransferase), ALB (albumin), CA 19-9, HBV infection status, and these factors were entered into the nomogram. The proposed nomogram showed favorable discrimination and calibration both in the training set and validation set. The C-indexes of the training set and validation set were 0.720 and 0.696 respectively, which were both significantly higher than that of the staging system (C-index = 0.613, P < 0.001). In conclusion, the proposed nomogram may be served as an effective tool for prognostic evaluation of advanced PDAC.

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Is chronic hepatitis B infection a protective factor for the progression of advanced pancreatic ductal adenocarcinoma? An analysis from a large multicenter cohort study

Cited by 3 publications

References 38 publications

Effect of hepatitis B virus infection status on liver metastasis of nasopharyngeal carcinoma: a cohort study

Effect of hepatitis B virus infection status on liver metastasis of nasopharyngeal carcinoma: a cohort study

Is Hepatitis B Virus a Player in Pancreatic Cancer?

Development and Validation of a Nomogram for Predicting Survival in Patients with Advanced Pancreatic Ductal Adenocarcinoma

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