Is chlorhexidine-methacrylate as effective as chlorhexidine digluconate in preserving resin dentin interfaces?

Nawareg, Manar Abu; Elkassas, Dina; Zidan, Ahmed; Abuelenain, Dalia A.; Haimed, Tariq S. Abu; Hassan, Ali; Chiba, Ayaka; Bock, Thorsten; Agee, Kelli A.; Pashley, David H.

doi:10.1016/j.jdent.2015.11.002

Cited by 20 publications

(29 citation statements)

References 39 publications

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“…In this way, CHX would both bind to demineralized dentin 67 and copolymerize with adhesive monomers: CHX-methacrylate would be much more than electrostatically bound to the dentin matrix, it would be sealed inside it, maybe for many years. 110 Then CHX-methacrylate could inhibit matrix proteases probably the same way CHX digluconate can do. 110 C H X i s a c at ion ic b i sb ig u a n ide wh ic h inhibits collagenase/gelatinase activity of dentin matrices.…”

Section: Enzymatic Inhibitorsmentioning

confidence: 99%

“…110 Then CHX-methacrylate could inhibit matrix proteases probably the same way CHX digluconate can do. 110 C H X i s a c at ion ic b i sb ig u a n ide wh ic h inhibits collagenase/gelatinase activity of dentin matrices. 74,37,111,112 It is believed that it acts by cation chelation, sequestrating calcium and zinc ions that are essential for the activation of the MMPs catalytic domains.…”

Section: Enzymatic Inhibitorsmentioning

confidence: 99%

“…102,104 An adhesive system containing 0.2% chlorhexidine (Peak Universal Bond, Ultradent Products Inc, South Jordan, USA) was then just introduced in the market. 6 As an alternative, Abu Nawareg et al 110 successfully used a monomer named CHX-methacrylate (Ivoclar Vivadent, Schaan, Liechtenstein) as a primer to improve hybrid layer long-term stability. In this way, CHX would both bind to demineralized dentin 67 and copolymerize with adhesive monomers: CHX-methacrylate would be much more than electrostatically bound to the dentin matrix, it would be sealed inside it, maybe for many years.…”

Section: Enzymatic Inhibitorsmentioning

confidence: 99%

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Bonding efficiency and durability: current possibilities

et al. 2017

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Bonding plays a major role in dentistry nowadays. Dental adhesives are used in association with composites to solve many restorative issues. However, the wide variety of bonding agents currently available makes it difficult for clinicians to choose the best alternative in terms of material and technique, especially when different clinical situations are considered. Moreover, although bonding agents allow for a more conservative restorative approach, achieving a durable adhesive interface remains a matter of concern, and this mainly due to degradation of the bonding complex in the challenging oral environment. This review aims to present strategies that are being used or those still in development which may help to prevent degradation. It is fundamental that professionals are aware of these strategies to counteract degradation as much as possible. None of them are efficient to completely solve this problem, but they certainly represent reasonable alternatives to increase the lifetime of adhesive restorations.

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Section: Enzymatic Inhibitorsmentioning

confidence: 99%

Section: Enzymatic Inhibitorsmentioning

confidence: 99%

Section: Enzymatic Inhibitorsmentioning

confidence: 99%

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Bonding efficiency and durability: current possibilities

et al. 2017

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“…The chlorhexidine solution has been added to preserve the dentin bonding and reduce collagen fibrils degradation. Studies have shown that dentin collagen degradation activity can be reduced using chlorhexidine application after acid etching [17][18][19]. However, there is no in vitro study or clinical trial that evaluated the use of 0.2 % chlorhexidine incorporated into adhesive solution and its effect on dentin bonding.…”

Section: Discussionmentioning

confidence: 99%

Bond strength and micromorphology of resin-dentin interface of etch-and-rinse dentin bonding agents after 1-year of water storage

et al. 2016

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“…As shown by studies retrieved for full-text reading, two distinct forms of chlorhexidine have been tested: chlorhexidine- methacrylate (32) and chlorhexidine digluconate (33). The former was tested by adding it into an experimental primer (therapeutic primer) and, according to the authors of that study, the monomer could co-polymerize with other monomers, thus improving stability of the hybrid layer.…”

Section: Collagen Crosslinking Agentsmentioning

confidence: 99%

Recent Advances in Adhesive Bonding: The Role of Biomolecules, Nanocompounds, and Bonding Strategies in Enhancing Resin Bonding to Dental Substrates

Münchow

Bottino

2017

Curr Oral Health Rep

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Purpose of review To present an overview on the main agents (i.e., biomolecules and nanocompounds) and/or strategies currently available to amplify or stabilize resin-dentin bonding. Recent findings According to studies retrieved for full text reading (2014–2017), there are currently six major strategies available to overcome resin-dentin bond degradation: (i) use of collagen crosslinking agents, which may form stable covalent bonds with collagen fibrils, thus strengthening the hybrid layer; (ii) use of antioxidants, which may allow further polymerization reactions over time; (iii) use of protease inhibitors, which may inhibit or inactivate metalloproteinases; (iv) modification of the bonding procedure, which may be performed by using the ethanol wet-bonding technique or by applying an additional adhesive (hydrophobic) coating, thereby strengthening the hybrid layer; (v) laser treatment of the substrate prior to bonding, which may cause specific topographic changes in the surface of dental substrates, increasing bonding efficacy; and (vi) reinforcement of the resin matrix with inorganic fillers and/or remineralizing agents, which may positively enhance physico-mechanical properties of the hybrid layer. Summary With the present review, we contributed to the better understanding of adhesion concepts and mechanisms of resin-dentin bond degradation, showing the current prospects available to solve that problematic. Also, adhesively-bonded restorations may be benefited by the use of some biomolecules, nanocompounds or alternative bonding strategies in order to minimize bond strength degradation.

show abstract

Is chlorhexidine-methacrylate as effective as chlorhexidine digluconate in preserving resin dentin interfaces?

Cited by 20 publications

References 39 publications

Bonding efficiency and durability: current possibilities

Bonding efficiency and durability: current possibilities

Bond strength and micromorphology of resin-dentin interface of etch-and-rinse dentin bonding agents after 1-year of water storage

Recent Advances in Adhesive Bonding: The Role of Biomolecules, Nanocompounds, and Bonding Strategies in Enhancing Resin Bonding to Dental Substrates

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