Is celiac disease better identified through HLA-DQ8 than through HLA-DQ2 in Mexican subjects?

Cerda-Contreras, Eduardo; Ramírez-Cervantes, Karen Lizzette; Granados, Julio; Mena, Lourdes; Núñez‐Álvarez, Carlos A.; Uscanga, Luis

doi:10.1016/j.rgmxen.2018.06.003

Cited by 2 publications

(3 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the European population, the frequency of this variant is 17.8% in CD patients [ 20 ]. The frequency of the HLA DQ2 variant is 90%, while the frequency of HLA DQ8 is between 5% and 10% [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

Meta-Analysis and Systematic Review of HLA DQ2/DQ8 in Adults with Celiac Disease

Aboulaghras

Piancatelli

Taghzouti

et al. 2023

IJMS

View full text Add to dashboard Cite

Although people with human leukocyte antigens (HLA) DQ2 and/or DQ8 are more likely to develop celiac disease (CD), the condition cannot be fully explained by this genetic predisposition alone. Multiple, as yet unidentified, factors contribute to the genesis of CD, including genetics, the environment, and the immune system. In order to provide insight into a prospective possibility and an expanded screening technique, we aim to undertake a comprehensive and meta-analytical study of the assessment and distribution of HLA class II (HLA-DQ2/DQ8) in adult CD patients. A systematic review was conducted using an electronic search of databases (PubMed, Google Scholar, Embase, and Direct Science) from January 2004 to February 2022. DQ2/DQ2 homozygotes have the highest risk of developing CD. DQ2/DQ8 typing is an effective test to exclude CD from the differential diagnosis of a patient with CD symptoms. Although other non-HLA genes have been associated with CD, they are rarely considered at diagnosis because they account for only a small proportion of the heritability of CD. This finding, together with the information gathered previously, may be useful in considering widely available and economically feasible screening options for celiac disease in young people.

show abstract

Section: Discussionmentioning

confidence: 99%

Meta-Analysis and Systematic Review of HLA DQ2/DQ8 in Adults with Celiac Disease

Aboulaghras

Piancatelli

Taghzouti

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…8 Está descrita una mayor prevalencia de la variante HLA-DQ8 en poblaciones latinoamericanas. 9 La Organización Mundial de la Salud (OMS) define la salud como un estado de completo bienestar físico, mental y social, y no solamente como la ausencia de afecciones o enfermedades. 10 En 1997, la OMS propuso la necesidad de promover el empoderamiento en la salud del individuo.…”

Section: Palabras Claves Calidad De Vida Empoderamiento Para La Salud...unclassified

“…Resultados. Treinta y seis personas fueron incluidas en el estudio, de las cuales el 86,1% eran mujeres, con una mediana de tiempo desde el diagnóstico de 7,0 años [5,[0][1][2][3][4][5][6][7][8][9][10]0]. El 75% reportó seguir la dieta libre de gluten en forma estricta.…”

Section: Introductionunclassified

Empoderamiento y calidad de vida en adultos con enfermedad celíaca en El Salvador. Estudio transversal

Espinal¹,

Peña

Serrano-Vela³

2022

Acta gastroenterol. latinoam.

View full text Add to dashboard Cite

Introduction. Celiac disease is a chronic disease with worldwide distribution. In the person-centered health approach to chronic diseases, the concepts of empowerment and quality of life become relevant. Aim. To determine the degree of empowerment and quality of life of adults with celiac disease in a sample from El Salvador, as well as the correlation between both measures. Materials y methods. Descriptive cross-sectional study. Salvadoran adults with diagnosis of celiac disease confirmed by duodenal biopsy were surveyed online. Sociodemographic and clinical data were required from the participants. A validated questionnaire in Spanish for the empowerment of people with chronic diseases was applied because there is no specific empowerment questionnaire for people with celiac disease. A validated quality of life questionnaire in Spanish for people with celiac disease was also used. Results. Thirty-six people were included in the study, of whom 86.1% were females, with a median time since diagnosis of 7.0 years [5.0-10.0]. Seventy-five percent reported a strict adherence to the gluten-free diet. The median empowerment score was 185.0 [176.25-195.0] out of 235 points and the median quality of life score was 72.5 [54.0-79.75] out of 100 points. The Spearman correlation between empowerment and quality of life was positive and statistically significant (rho = 0.444; p = 0.007). The people evaluated in this study have a good level of empowerment and quality of life. Conclusion. There is a moderate positive correlation between empowerment and quality of life for adults with celiac disease in this study.

show abstract

Is celiac disease better identified through HLA-DQ8 than through HLA-DQ2 in Mexican subjects?

Cited by 2 publications

References 16 publications

Meta-Analysis and Systematic Review of HLA DQ2/DQ8 in Adults with Celiac Disease

Meta-Analysis and Systematic Review of HLA DQ2/DQ8 in Adults with Celiac Disease

Empoderamiento y calidad de vida en adultos con enfermedad celíaca en El Salvador. Estudio transversal

Contact Info

Product

Resources

About