Is Celiac Disease an Etiological Factor in Children With Migraine?

Balcı, Oya; Yılmaz, Deniz; Sezer, Taner; Hızlı, Şamil

doi:10.1177/0883073816630088

Cited by 7 publications

(5 citation statements)

References 18 publications

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“…Information about prevalence of GS in children with headache (all reporting migraine), was available through three case-controlled studies [ 41 , 47 , 48 ]. As shown in Figure 6 , the pooled mean prevalence of GS in children with idiopathic migraine is 6.2% (95% CI 2.6–14.1%).…”

Section: Resultsmentioning

confidence: 99%

Headache Associated with Coeliac Disease: A Systematic Review and Meta-Analysis

2018

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Objective: The aim of this systematic review was to explore the relationship between coeliac disease (CD) and headache. The objectives were to establish the prevalence of each entity amongst the other, to explore the role of gluten free diet (GFD), and to describe the imaging findings in those affected by headaches associated with CD. Methodology: A systematic computer-based literature search was conducted on the PubMed database. Information regarding study type, population size, the age group included, prevalence of CD amongst those with headache and vice versa, imaging results, the nature of headache, and response to GFD. Results: In total, 40 articles published between 1987 and 2017 qualified for inclusion in this review. The mean pooled prevalence of headache amongst those with CD was 26% (95% CI 19.5–33.9%) in adult populations and 18.3% (95% CI 10.4–30.2%) in paediatric populations. The headaches are most often migraine-like. In children with idiopathic headache, the prevalence of CD is 2.4% (95% CI 1.5–3.7%), whereas data for adult populations is presently unavailable. Brain imaging can be normal, although, cerebral calcifications on CT, white matter abnormalities on MRI and deranged regional cerebral blood flow on SPECT can be present. GFD appears to be an effective management for headache in the context of CD, leading to total resolution of headaches in up to 75% of patients. Conclusions: There is an increased prevalence of CD amongst idiopathic headache and vice versa. Therefore, patients with headache of unknown origin should be screened for CD, as such patients may symptomatically benefit from a GFD.

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Section: Resultsmentioning

confidence: 99%

Headache Associated with Coeliac Disease: A Systematic Review and Meta-Analysis

2018

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“…Faced with a higher prevalence of migraine in CD patients compared to controls, current evidence does not clearly support the adoption of a routine search for IgA antitransglutamase antibodies within the diagnostic approach for patients with migraine [ 278 , 279 ]. Only one cross-sectional study has reported a higher prevalence of positive tissue transglutaminase IgA (tTGA) antibodies in a group of paediatric migraine patients (5.5%), compared to age- and sex-matched controls (0.6%).…”

Section: Headache and Immuno-mediated Gastrointestinal Disordersmentioning

confidence: 99%

Headache and immunological/autoimmune disorders: a comprehensive review of available epidemiological evidence with insights on potential underlying mechanisms

Biscetti

Vanna

Cresta

et al. 2021

J Neuroinflammation

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Several lines of evidence support a role of the immune system in headache pathogenesis, with particular regard to migraine. Firstly, alterations in cytokine profile and in lymphocyte subsets have been reported in headache patients. Secondly, several genetic and environmental pathogenic factors seem to be frequently shared by headache and immunological/autoimmune diseases. Accordingly, immunological alterations in primary headaches, in particular in migraine, have been suggested to predispose some patients to the development of immunological and autoimmune diseases. On the other hand, pathogenic mechanisms underlying autoimmune disorders, in some cases, seem to favour the onset of headache. Therefore, an association between headache and immunological/autoimmune disorders has been thoroughly investigated in the last years. The knowledge of this possible association may have relevant implications in the clinical practice when deciding diagnostic and therapeutic approaches. The present review summarizes findings to date regarding the plausible relationship between headache and immunological/autoimmune disorders, starting from a description of immunological alteration of primary headaches, and moving onward to the evidence supporting a potential link between headache and each specific autoimmune/immunological disease.

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“…The other study, conducted by Balci et al, reported similar results, with 2 among the 81 patients having migraine exhibiting positivity for anti-tTG antibodies compared to 1 among the 176 controls (p = ns). In the same study, the duodenal biopsy was negative in all the subjects, who were then considered 'potential celiacs' [24].…”

Section: Prevalence Of Celiac Disease In Both Adult and Pediatric Patients With Migrainementioning

confidence: 99%

“…In a study by Lahat et al, it was observed that the anti-Endomysial antibodies were negative in all 41 children with migraine headache (1-16 years of age) [22]. Five related case-control studies are available in the literature [23][24][25][26][27], two of which, both conducted with the Turkish population, reported negative findings [23,24]. In one of these studies, no difference was observed in the positivity of anti-tTG between the migraine patients and the healthy controls (2% in both; 2/100 versus 30/1500, respectively) [23].…”

Section: Prevalence Of Celiac Disease In Both Adult and Pediatric Patients With Migrainementioning

confidence: 99%

Migraine as a Common Extra-Intestinal Presentation of Celiac Disease

Gabrielli¹,

Ojetti²,

Candelli³

et al. 2021

OBM Neurobiology

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Celiac disease (CD) is a common gluten-related enteropathy that presents several extra-intestinal manifestations. Migraine is globally recognized as one of the most diffuse primary headaches. The present paper aims to review the current evidence on the possible association between CD and migraine. Both adults and children having CD exhibit a high prevalence of migraine. However, screening for CD in an unselected population of migraineurs demonstrated contrasting results. Brain imaging may reveal cerebral calcifications and/or white matter abnormalities in a small number of patients having migraine with underlying CD. Limited data are available on the effects of gluten-free diet (GDF) on migraine in the patients affected by CD, suggesting the efficacy of such intervention on the migraine symptoms in both adults and children. Nonetheless, this inference requires verification with high-quality trials conducted with larger sample sizes and longer follow-up periods.

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Is Celiac Disease an Etiological Factor in Children With Migraine?

Cited by 7 publications

References 18 publications

Headache Associated with Coeliac Disease: A Systematic Review and Meta-Analysis

Headache Associated with Coeliac Disease: A Systematic Review and Meta-Analysis

Headache and immunological/autoimmune disorders: a comprehensive review of available epidemiological evidence with insights on potential underlying mechanisms

Migraine as a Common Extra-Intestinal Presentation of Celiac Disease

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