Is CD36 gene polymorphism in region encoding lipid-binding domain associated with early onset CAD?

Rać, Monika; Safranow, Krzysztof; Kurzawski, Grzegorz; Krzystolik, Andrzej; Chlubek, Dariusz

doi:10.1016/j.gene.2013.06.061

Cited by 6 publications

(6 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, most of the studies assessed European populations. Similar to the above-mentioned studies ( 8 , 9 ), we observed an rs3173798 polymorphism in the CHD group, but there was no significant difference in the distribution of genotypes and T/C allele frequencies between the two groups in the Chongqing Han population (all P>0.05). We preliminarily deduced that rs3173798 polymorphism had no direct correlation with CHD.…”

Section: Discussionsupporting

confidence: 90%

“…However, other studies did not find evidence that rs3173798 polymorphism was associated with radiological markers of AS progression in Caucasian patients diagnosed with CHD at a young age. Additionally, rs3173798 did not seem to be involved in the risk of early onset CHD in Caucasian populations ( 8 , 9 ). Associations of rs3173798 polymorphism with CHD seem to be controversial.…”

Section: Discussionmentioning

confidence: 99%

“…In the human CD36 gene, 1372 single nucleotide polymorphisms (SNPs) have been reported to date ( 7 ). Associations of some SNPs (e.g., rs5956, rs3173798, and rs3211892) with CHD have been detected, but the conclusions are controversial ( 8 , 9 ). Other SNPs (e.g., rs1761667, rs1527483, rs1049673, and rs3211931) have been shown to be related with type 2 diabetes mellitus (T2DM) or metabolic syndrome (MetS) but do not have direct association with CHD ( 10 , 11 ).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Associations between CD36 gene polymorphisms and susceptibility to coronary artery heart disease

Zhang

Ling

Deng

et al. 2014

Braz J Med Biol Res

View full text Add to dashboard Cite

Associations between polymorphisms of the CD36 gene and susceptibility to coronary artery heart disease (CHD) are not clear. We assessed allele frequencies and genotype distributions of CD36 gene polymorphisms in 112 CHD patients and 129 control patients using semi-quantitative polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. Additionally, we detected CD36 mRNA expression by real-time quantitative PCR, and we quantified plasma levels of oxidized low-density lipoprotein (ox-LDL) using an enzyme-linked immunosorbent assay (ELISA). There were no significant differences between the two groups (P>0.05) in allele frequencies of rs1761667 or in genotype distribution and allele frequencies of rs3173798. The genotype distribution of rs1761667 significantly differed between CHD patients and controls (P=0.034), with a significantly higher frequency of the AG genotype in the CHD group compared to the control group (P=0.011). The plasma levels of ox-LDL in patients with the AG genotype were remarkably higher than those with the GG and AA genotypes (P=0.010). In a randomized sample taken from patients in the two groups, the CD36 mRNA expression of the CHD patients was higher than that of the controls. In CHD patients, the CD36 mRNA expression in AG genotype patients was remarkably higher than in those with an AA genotype (P=0.005). After adjusted logistic regression analysis, the AG genotype of rs1761667 was associated with an increased risk of CHD (OR=2.337, 95% CI=1.336-4.087, P=0.003). In conclusion, the rs1761667 polymorphism may be closely associated with developing CHD in the Chongqing Han population of China, and an AG genotype may be a genetic susceptibility factor for CHD.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Associations between CD36 gene polymorphisms and susceptibility to coronary artery heart disease

Zhang

Ling

Deng

et al. 2014

Braz J Med Biol Res

View full text Add to dashboard Cite

show abstract

“…Understanding the expression profiles and functionality of the receptors in disease cohorts and a long-term follow-up of CAD patients may be critical to linking the CD36 receptor functions to cardiovascular diseases. Given this context, our earlier studies published in Gene [13] showed no differences in the frequencies of CD36 variants between neonates and early-onset CAD patients. Only a borderline difference was found in the frequencies of rs141680676, i.e., the A591T genotypes of CD36.…”

Section: Introductionmentioning

confidence: 85%

Prognostic Value of the Selected Polymorphisms in the CD36 Gene in the Domain-Encoding Lipid-Binding Region at a 10-Year Follow-Up for Early-Onset CAD Patients

Bartoszewicz¹,

Rać

2023

Biomedicines

Self Cite

View full text Add to dashboard Cite

The polymorphism of the CD36 gene may have a decisive impact on the formation and progression of atherosclerotic changes. The aim of the study was to confirm the prognostic values of the previously studied polymorphisms in the CD36 gene within a 10-year follow-up period. This is the first published report confirming the long-term observation of patients with CAD. The study group covered 100 early-onset CAD patients. It included 26 women not older than 55 years and 74 men not older than 50 years, tested in a ten-year study as a long-term follow-up after the first cardiovascular episode. There are no notable differences between the CD36 variants and the number of fatalities during observation, fatalities due to cardiological reasons, cases of myocardial infarction within a ten-year observation period, hospitalizations for cardiovascular issues, all cardiovascular occurrences, and the number of months lived. We have shown that the CD36 variants analyzed in this study do not appear to be related to the risk of early CAD occurrence in the Caucasian population in long-term observation.

show abstract

“…Along with the nutritional perspective, many CD36 SNP have been reported to be associated with various diseases and metabolic abnormalities in European and African American populations (5,8,10,11,(13)(14)(15)(17)(18)(19)(20)(21)(22)(23)(24) . Based on these previous studies, recent case-control studies have investigated the associations of CD36 polymorphisms with ischaemic stroke (25,26) and CHD in Asian populations (27)(28)(29) .…”

mentioning

confidence: 99%

Cluster of differentiation 36 gene polymorphism (rs1761667) is associated with dietary MUFA intake and hypertension in a Japanese population

et al. 2019

View full text Add to dashboard Cite

Cluster of differentiation 36 (CD36) is a membrane receptor expressed on a wide variety of human cells. CD36 polymorphisms are reportedly associated with oral fat perception, dietary intake and metabolic disorders. The present study examined associations of two CD36 polymorphisms (rs1761667 and rs1527483) and dietary fat intake, and metabolic phenotypes in a Japanese population. This cross-sectional study was conducted based on clinical information collected from health check-ups in Japan (n 495). Dietary nutrient intake was estimated from a validated short FFQ and adjusted for total energy intake using the residual method. Mean blood pressure was calculated from systolic blood pressure (SBP) and diastolic blood pressure (DBP). Hypertension was defined as SBP ≥ 130 mmHg and/or DBP ≥ 85 mmHg, or use of antihypertensive drugs. Genotyping was performed using PCR with confronting two-pair primers method. Mean age was 63·4 (sd 9·9) years. Individuals with the AA genotype showed higher total fat and MUFA intake (standardised β = 0·110 and 0·087, P = 0·01 and 0·05, respectively) compared with the GG and GA genotypes. For metabolic phenotypes, the AA genotype of rs1761667 had a lower blood pressure compared with the GG genotype (standardised β = –0·123, P = 0·02). Our results suggested that the AA genotype of rs1761667 in the CD36 gene was associated with higher intake of total fat and MUFA and lower risk of hypertension in a Japanese population.

show abstract

Is CD36 gene polymorphism in region encoding lipid-binding domain associated with early onset CAD?

Cited by 6 publications

References 24 publications

Associations between CD36 gene polymorphisms and susceptibility to coronary artery heart disease

Associations between CD36 gene polymorphisms and susceptibility to coronary artery heart disease

Prognostic Value of the Selected Polymorphisms in the CD36 Gene in the Domain-Encoding Lipid-Binding Region at a 10-Year Follow-Up for Early-Onset CAD Patients

Cluster of differentiation 36 gene polymorphism (rs1761667) is associated with dietary MUFA intake and hypertension in a Japanese population

Contact Info

Product

Resources

About