Is carbon dioxide laser vaporization a valuable tool in the management of oral leukoplakia? A survey at an oncology hospital

Oral leukoplakia treatment with the carbon dioxide laser: A systematic review of the literature

“…On the other hand, although there is no evidence that treatment prevents OL developing into OSCC, the transformation rate can be significantly decreased with CO 2 laser treatment (Yang et al, 2011;Jerjes et al, 2012;Brouns et al, 2013Brouns et al, , 2014Pedrosa et al, 2015;Mogedas-Vegara et al, 2015).…”

“…Some authors have used the term cumulative disease-free survival (DFS) in order to avoid confusion in reporting recurrence rates per lesion or per patient. Chiesa et al (1993) reported DFS rates of 70.7% and 51.5% at 3 and 5 years, respectively; Chandu and Smith (2005) reported DFS rates of 55.4% (95% CI; 38.3e72.5) after 3 years and of 33.9% (95% CI; 10.2e57.5) after 5 years; Pedrosa et al (2015) reported an overall DFS rate of 88% after 1-year follow-up. Since it seems that recurrence is unavoidable due to field cancerization, tight follow-up is advisable (Slaughter et al, 1953;Yang et al, 2011;Mogedas-Vegara et al, 2015).…”

“…In implementing OL treatment with the CO 2 laser, there is no standardized protocol of how to carry out the procedure. While some authors excised the lesion (Del Corso et al, 2015), there are others that vaporized the lesion (Huerta et al, 1999;Gooris et al, 1999;Dunsche et al, 2000;Van der Hem et al, 2005;Chandu et al, 2005;Deppe et al, 2012;Brouns et al, 2013;Pedrosa et al, 2015;Mogedas-Vegara et al, 2015) and yet others combined both approaches (Thomson et al, 2002;Yang et al, 2011). The need for an accurate pre-operative biopsy specimen which is as representative as possible of the lesion as a whole, to ensure ablation of a carcinoma is not occurring, is mandatory.…”

“…Apart from pain, other complications reported were mental nerve paraesthesia, lingual nerve paraesthesia, headache, sialadenitis, granuloma formation and bleeding (Chu et al, 1988;Thomson et al, 2002;Chandu et al, 2005;Yang et al, 2011;Jerjes et al, 2012;Brouns et al, 2013;Pedrosa et al, 2015;Mogedas-Vegara et al, 2015).…”

“…These studies are summarized in Table 2 (Frame, 1985;Horch et al, 1986;Chu et al, 1988;Roodenburg et al, 1991;Chiesa et al, 1993;Huerta et al, 1999;Gooris et al, 1999;Dunsche et al, 2000;Thomson et al, 2002;Van der Hem et al, 2005;Chandu et al, 2005;Yang et al, 2011;Jerjes et al, 2012;Brouns et al, 2013Brouns et al, , 2014Pedrosa et al, 2015;Mogedas-Vegara et al, 2015).…”