Is cancer chemotherapy dying?

Mb, Agarwal

doi:10.4103/0973-6247.182735

Cited by 13 publications

(10 citation statements)

References 30 publications

(33 reference statements)

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“…Triple-negative BC, the subtype with the poorest prognosis, has limited therapeutic options (i.e., chemotherapy) ( Mehanna et al, 2019 ). However, chemotherapy is non-specific, which can cause damage to normal tissues and result in significant adverse effects ( Agarwal, 2016 ). Moreover, early-stage BC in around 20–30% of patients may progress to become metastatic, which is largely incurable ( Pulido et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Hesperidin and its aglycone hesperetin in breast cancer therapy: A review of recent developments and future prospects

Yap

Sekar

et al. 2021

Saudi Journal of Biological Sciences

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Breast cancer (BC) has high incidence and mortality rates, making it a major global health issue. BC treatment has been challenging due to the presence of drug resistance and the limited availability of therapeutic options for triple-negative and metastatic BC, thereby urging the exploration of more effective anti-cancer agents. Hesperidin and its aglycone hesperetin, two flavonoids from citrus species, have been extensively evaluated for their anti-cancer potentials. In this review, available literatures on the chemotherapeutic and chemosensitising activities of hesperidin and hesperetin in preclinical BC models are reported. The safety and bioavailability of hesperidin and hesperetin as well as the strategies to enhance their bioavailability are also discussed. Overall, hesperidin and hesperetin can inhibit cell proliferation, migration and BC stem cells as well as induce apoptosis and cell cycle arrest in vitro . They can also inhibit tumour growth, metastasis and neoplastic changes in tissue architecture in vivo . Moreover, the co-administration of hesperidin or hesperetin with doxorubicin, letrozole or tamoxifen can enhance the efficacies of these clinically available agents. These chemotherapeutic and chemosensitising activities of hesperidin and hesperetin have been linked to several mechanisms, including the modulation of signalling pathways, glucose uptake, enzymes, miRNA expression, oxidative status, cell cycle regulatory proteins, tumour suppressor p53, plasma and liver lipid profiles as well as DNA repair mechanisms. However, poor water solubility, extensive phase II metabolism and apical efflux have posed limitations to the bioavailability of hesperidin and hesperetin. Various strategies for bioavailability enhancement have been studied, including the utilisation of nano-based drug delivery systems and the co-administration of hesperetin with other flavonoids. In particular, nanoformulated hesperidin and hesperetin possess greater chemotherapeutic and chemosensitising activities than free compounds. Despite promising preclinical results, further safety and efficacy evaluation of hesperidin and hesperetin as well as their nanoformulations in clinical trials is required to ascertain their potentials to be developed as clinically useful agents for BC treatment.

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Section: Introductionmentioning

confidence: 99%

Hesperidin and its aglycone hesperetin in breast cancer therapy: A review of recent developments and future prospects

Yap

Sekar

et al. 2021

Saudi Journal of Biological Sciences

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“…Chemotherapy for cancer treatment still suffers a lot of deficiencies due to the toxicity of the chemotherapeutics to healthy normal cells and also to resistance advanced via tumor cells to the anticancer medication [ 48 ]. The main problem with cancer chemotherapeutics is the lack of selectivity to tumor cells and because of that a less effective antitumor effect.…”

Section: Challenges Of Biomacromolecules and Chemotherapeutics Deliverymentioning

confidence: 99%

Delivery of Various Cargos into Cancer Cells and Tissues via Cell-Penetrating Peptides: A Review of the Last Decade

et al. 2021

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Cell-penetrating peptides (CPPs), also known as protein transduction domains, are a class of diverse amino acid sequences with the ability to cross cellular membranes. CPPs can deliver several bioactive cargos, including proteins, peptides, nucleic acids and chemotherapeutics, into cells. Ever since their discovery, synthetic and natural CPPs have been utilized in therapeutics delivery, gene editing and cell imaging in fundamental research and clinical experiments. Over the years, CPPs have gained significant attention due to their low cytotoxicity and high transduction efficacy. In the last decade, multiple investigations demonstrated the potential of CPPs as carriers for the delivery of therapeutics to treat various types of cancer. Besides their remarkable efficacy owing to fast and efficient delivery, a crucial benefit of CPP-based cancer treatments is delivering anticancer agents selectively, rather than mediating toxicities toward normal tissues. To obtain a higher therapeutic index and to improve cell and tissue selectivity, CPP-cargo constructions can also be complexed with other agents such as nanocarriers and liposomes to obtain encouraging outcomes. This review summarizes various types of CPPs conjugated to anticancer cargos. Furthermore, we present a brief history of CPP utilization as delivery systems for anticancer agents in the last decade and evaluate several reports on the applications of CPPs in basic research and preclinical studies.

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“…However, cancer patients' responses to these remedies vary considerably for different types of cancer. An optimal cancer treatment would kill only cancer or tumor cells, but most chemotherapy forms involve a non-specific targeting of chemotherapeutic drugs to curb uncontrolled cell division and growth [17]. The primary shortcomings of chemotherapy and radiotherapy are multidrug resistance, the reappearance of tumors, dose-limiting side effects in normal cells, and economic burden [18].…”

Section: Conventional Forms Of Cancer Treatmentmentioning

confidence: 99%

Phytochemicals in Chemoprevention: A Cost-Effective Complementary Approach

2021

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Cancer is one of the leading causes of death across the world. Although conventional cancer treatments such as chemotherapy and radiotherapy have effectively decreased cancer progression, they come with many dose-limiting side-effects. Phytochemicals that naturally occur in spices, fruits, vegetables, grains, legumes, and other common foods are surprisingly effective complements to conventional cancer treatments. These biologically active compounds demonstrate anticancer effects via cell signaling pathway interference in cancerous cells. In addition, phytochemicals protect non-cancerous cells from chemotherapy-induced side-effects. This paper addresses the not only the potential of phytochemicals quercetin, isoflavones, curcumin, catechins, and hesperidin in terms of cancer treatment and protection against side-effects of chemotherapy, but also methods for increasing phytochemical bioavailability.

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Is cancer chemotherapy dying?

Cited by 13 publications

References 30 publications

Hesperidin and its aglycone hesperetin in breast cancer therapy: A review of recent developments and future prospects

Hesperidin and its aglycone hesperetin in breast cancer therapy: A review of recent developments and future prospects

Delivery of Various Cargos into Cancer Cells and Tissues via Cell-Penetrating Peptides: A Review of the Last Decade

Phytochemicals in Chemoprevention: A Cost-Effective Complementary Approach

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