Is C677T Polymorphism in Methylenetetrahydrofolate Reductase Gene a Risk Factor for Diabetic Nephropathy or Diabetes Mellitus in a Chinese Population?

Cui, Wenpeng; Du, Bing; Jia, Yong; Zhou, Wenhua; Liu, Shengmao; Cui, Yingchun; Ma, Fuzhe; Luo, Ping; Miao, Lining

doi:10.1016/j.arcmed.2011.12.003

Cited by 20 publications

(11 citation statements)

References 62 publications

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“…15 First, the data reported by Cui et al for the study by Cao et al 16 do not seem in line with the data provided by Cao et al in their original publication. In the study by Cao et al, the control group is comprised of healthy subjects and the case group is comprised of subjects with DN with type 2 diabetic patients.…”

Section: Introductioncontrasting

confidence: 39%

Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and susceptibility to diabetic nephropathy in Chinese type 2 diabetic patients: a meta-analysis

et al. 2013

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The association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and diabetic nephropathy (DN) or diabetes mellitus (DM) risk has been widely reported, but the results are still debatable. To investigate the role of MTHFR C677T polymorphism on DM or DN, 13 separate studies in the Chinese population on the relation between MTHFR C677T polymorphism and DM or DN were analyzed by a meta-analysis. Five genetic models were used to estimate the association between MTHFR C677T polymorphism and the risk of DM or DN. Overall, our meta-analysis for DN versus healthy controls produced significant results for all genetic contrasts except for the co-dominant model (allele contrast: OR ¼ 2.24, 95%CI: 1.88-2.65, p50.00001, P heterogeneity ¼ 0.49). However, the meta-analysis for DM versus healthy controls produced non-significant results for all contrasts (allele contrast: OR ¼ 1.12, 95%CI: 0.92-1.35, p ¼ 0.25, P heterogeneity ¼ 0.07). In addition, the meta-analysis for DM versus DN produced significant results for all contrasts (allele contrast: OR ¼ 1.88, 95%CI: 1.65-2.15, p50.00001, P heterogeneity ¼ 0.83). The current meta-analysis suggested that MTHFR C677T polymorphism might influence DN risk, but not for DM in the Chinese population.

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Section: Introductioncontrasting

confidence: 39%

Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and susceptibility to diabetic nephropathy in Chinese type 2 diabetic patients: a meta-analysis

et al. 2013

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“…Although there are many studies analyzing the research results about the MTHFR C677T polymorphism and their associations with DN, definite conclusions cannot be drawn. Up to this time, there are five published meta‐analyses regarding MTHFR C677T polymorphism and DN risk . Of these, one meta‐analysis reported that there was significant association between MTHFR C677T polymorphism and DN risk in Caucasian individuals .…”

Section: Discussionmentioning

confidence: 99%

Association between MTHFR C677T polymorphism and diabetic nephropathy in the Chinese population: An updated meta‐analysis and review

et al. 2015

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colleagues have performed a meta analysis and review of the Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism on the risk of diabetic nephropathy (DN) in the Chinese population. This meta-analysis, which analyzed 15 studies, clarifies that the MTHFR C677T variants may influence DN risk in the Chinese population, in particular, in the Han, North and South China. ABSTRACT:To clarify the effects of MTHFR C677T polymorphism on the risk of diabetic nephropathy (

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“…Epidemiological studies have shown several risk factors for patients with CVD and CKD, such as heredity [6, 7], diabetes [8, 9], anemia [10], and hyperlipidemia [11, 12], but nontraditional risk factors such as oxidative stress may also contribute to these diseases [13, 14]. Our understanding of how oxidative stress contributes to cardiovascular and renal diseases has undergone considerable evolution over the past two decades.…”

Section: Introductionmentioning

confidence: 99%

Preventive and Therapeutic Effects of MG132 by Activating Nrf2-ARE Signaling Pathway on Oxidative Stress-Induced Cardiovascular and Renal Injury

Cui

Bai

Luo

et al. 2013

Oxidative Medicine and Cellular Longevity

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So far, cardiovascular and renal diseases have brought us not only huge economic burden but also serious society problems. Since effective therapeutic strategies are still limited, to find new methods for the prevention or therapy of these diseases is important. Oxidative stress has been found to play a critical role in the initiation and progression of cardiovascular and renal diseases. In addition, activation of nuclear-factor-E2-related-factor-2- (Nrf2-) antioxidant-responsive element (ARE) signaling pathway protects cells and tissues from oxidative damage. As a proteasomal inhibitor, MG132 was reported to activate Nrf2 expression and function, which was accompanied with significant preventive and/or therapeutic effect on cardiovascular and renal diseases under most conditions; therefore, MG132 seems to be a potentially effective drug to be used in the prevention of oxidative damage. In this paper, we will summarize the information available regarding the effect of MG132 on oxidative stress-induced cardiovascular and renal damage, especially through Nrf2-ARE signaling pathway.

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Is C677T Polymorphism in Methylenetetrahydrofolate Reductase Gene a Risk Factor for Diabetic Nephropathy or Diabetes Mellitus in a Chinese Population?

Cited by 20 publications

References 62 publications

Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and susceptibility to diabetic nephropathy in Chinese type 2 diabetic patients: a meta-analysis

Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and susceptibility to diabetic nephropathy in Chinese type 2 diabetic patients: a meta-analysis

Association between MTHFR C677T polymorphism and diabetic nephropathy in the Chinese population: An updated meta‐analysis and review

Preventive and Therapeutic Effects of MG132 by Activating Nrf2-ARE Signaling Pathway on Oxidative Stress-Induced Cardiovascular and Renal Injury

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