Is C-peptide a predictor of severity of coronary artery disease in metabolic syndrome? An observational study

Rama, Bhat

doi:10.1016/j.ihj.2018.07.005

Cited by 8 publications

(10 citation statements)

References 11 publications

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“…Moreover, fold changes of C-peptide during an OGTT were inversely associated with those of FGF21 in individuals with normal glucose tolerance (35), and FGF21 related signal pathways played important roles in the progression of NAFLD (36). In addition, previous studies have indicated that C-peptide may be also a predictive marker of the severity of the cardiovascular disease (37) and mortality (38), which suggested C-peptide was a bioactive peptide with other potential physiological functions. Thus, AUC CP may partly mediate the association between SUA/Cr and NAFLD via insulin resistance and other potential physiological function.…”

Section: Discussionmentioning

confidence: 99%

C-Peptide: A Mediator of the Association Between Serum Uric Acid to Creatinine Ratio and Non-Alcoholic Fatty Liver Disease in a Chinese Population With Normal Serum Uric Acid Levels

Liu

et al. 2020

Front. Endocrinol.

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BackgroundThe data on the relationship between normal-ranged serum uric acid (SUA), β-cell function, and non-alcoholic fatty liver disease (NAFLD) are complicated and insufficient. Moreover, uric acid is excreted by kidney, and SUA levels may be affected by renal function. Thus, we introduced a renal function-normalized index [serum uric acid to creatinine ratio (SUA/Cr)] into the study and explored the association between SUA/Cr, C‐peptide and NAFLD in a Chinese population with normal SUA levels by a cross-sectional analysis.Materials and MethodsA total of 282 individuals with normal SUA levels and different glucose tolerance status from a diabetes project were included in the study (mean age = 53.7± 10.5 years; women = 64.50%). NAFLD was diagnosed by abdominal ultrasonography (NAFLD, n=86; without NAFLD, n=196). Trapezoid formula was used to calculate area under the curve of C‐peptide (AUCCP) from 4 points (including 0, 30,60, and 120min) during 2-h oral glucose tolerance test. Spearman correlation analysis was used to explore the correlation between SUA/Cr, AUCCP and NAFLD risk factors. Multiple logistic regression analysis was used to explore the association between SUA/Cr or AUCCP and NAFLD. Mediation analysis was used to explore whether AUCCP mediated the association between SUA/Cr and NAFLD.ResultsIndividuals with NAFLD had significantly higher SUA/Cr and AUCCP than those without NAFLD(P<0.05). Spearman correlation analysis showed that both SUA/Cr and AUCCP were significantly associated with many NAFLD risk factors, and SUA/Cr was positively correlated with AUCCP (P<0.05). Multiple logistic regression analysis indicated that SUA/Cr and AUCCP were positively associated with NAFLD incidence (P<0.05). Medication analysis indicated that SUA/Cr had a significant direct effect on NAFLD (β =0.5854, 95% CI: 0.3232–0.8966), and AUCCP partly mediated the indirect effect of SUA/Cr on NAFLD incidence (β =0.1311, 95% CI: 0.0168–0.4663).ConclusionsSUA/Cr was positively associated with NAFLD incidence, and AUCCP partly mediated the association in a Chinese population with normal SUA levels. Thus, we should pay more attention to high-normal SUA and C-peptide levels due to their predictive power in NAFLD incidence.

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Section: Discussionmentioning

confidence: 99%

C-Peptide: A Mediator of the Association Between Serum Uric Acid to Creatinine Ratio and Non-Alcoholic Fatty Liver Disease in a Chinese Population With Normal Serum Uric Acid Levels

Liu

et al. 2020

Front. Endocrinol.

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“…(1) diagnosis of secondary hypertension (n � 106), (2) diagnosis of diabetes mellitus (n � 493), (3) severe arrhythmia (n � 34), (4) moderate to severe kidney dysfunction (estimated glomerular filtration rate (eGFR) ≤60 ml min −1 1.73 m 2 ) (n � 122), ( 5) left ventricular systolic dysfunction (LVEF <50%) (n � 58), (6) severe valvular heart disease (n � 26), (7) peripheral vascular diseases (PAD) (n � 62), ( 8) myocardial infarction or unstable angina pectoris (n � 156), and (9) those subjects missing dates of baPWV or C-peptide (n � 213). Finally, the present study contained a total of 730 subjects.…”

Section: Study Subjectsmentioning

confidence: 99%

“…C-peptide is cosecreted with insulin on an equimolar basis; this is more stable, has fewer influencing factors, and can better reflect the secretion ability of overall and residual islet ß-cell [4][5][6]. In addition, C-peptide may also be a predictive marker of the severity of cardiovascular disease [7] and mortality [8]; the research suggests that C-peptide is a bioactive peptide with other potential physiological functions. Meanwhile, the detection of C-peptide is simple and convenient.…”

Section: Introductionmentioning

confidence: 99%

Relationship between Insulin Secretion and Arterial Stiffness in Essential Hypertension

Sun

Zhu

Zhang

et al. 2021

International Journal of Hypertension

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The study aims to explore the relationship between plasma insulin secretion and arterial stiffness in nondiabetic essential hypertensive patients. A total of 730 nondiabetic essential hypertensive patients registered between January 2016 and October 2020 were enrolled. A two-hour oral glucose tolerance test (OGTT) was performed to detect the levels of C-peptide and blood glucose at 0 hours and 2 hours, as well as the difference between C-peptide (Δ C-peptide) and blood glucose (Δ blood glucose) over the same period. Patients were divided into two groups: the normal glucose tolerance (NGT) group (n = 322) and the impaired glucose tolerance (IGT) group (n = 408). A multiple linear regression analysis was used to evaluate the association between brachial-ankle pulse wave velocity (baPWV) and the other factors. 0 h C-peptide, 2 h C-peptide, and Δ C-peptide were found to be higher in the IGT group. baPWV was positively linear correlated with 2 h C-peptide (r = 0.086, p = 0.020 ) and Δ C-peptide (r = 0.115, p = 0.002 ). baPWV remained independently associated with 0 h C-peptide, 2 h C-peptide, and Δ C-peptide, after adjusting by age, gender, smoking, body mass index (BMI), high-density lipoprotein (HDL), cholesterol, systolic blood pressure (SBP), and triglycerides (TG). Our data shows that higher endogenous insulin secretion might play an important role in the progression of arterial stiffness in nondiabetic essential hypertensive patients.

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“…obesity characteristics) (Andrade et al, 2018). Gradually, C-peptide values have come to be considered as crucial for possible correlation with the circumstances of cardiovascular diseases (Harnishsingh and Rama, 2018).…”

Section: Introductionmentioning

confidence: 99%

Cholesterol and glucose profiles according to different fasting C-peptide levels: a cross-sectional analysis in a healthy cohort from the Czech Republic

Kron¹,

Verner²,

Pešl³

et al. 2021

JAB

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The relationship between glycaemia and lipoprotein metabolism has not been completely clarified, and slight differences may be found between local authors, trials and evaluated parameters. Therefore this cross-sectional study investigated fasting cholesterol and glucose levels along with the determination of atherogenic index in a cohort of healthy individuals from the Czech Republic in relation to their fasting C-peptide levels. Data were collected between 2009 and 2018 and a total of 3189 individuals were stratified by C-peptide reference range (260-1730 pmol/l) into three groups -below (n = 111), within (n = 2952) and above (n = 126). Total, HDL, LDL cholesterol and atherogenic index were used to compare lipoprotein levels by relevant C-peptide concentrations. Participants using the supplements to affect lipid or glycaemia metabolism were excluded from this study. The evaluation of blood parameters in a fasting state included correlations between C-peptide and cholesterols, differences of variances (F-test) and the comparison of lipoprotein mean values (t-test) between the groups created by the C-peptide reference range. Mean values of total (4.9, 5.1, 5.3 mmol/l), LDL (2.6, 3.1, 3.4 mmol/l) cholesterol and atherogenic index (2.1, 2.8, 3.7) were higher with increasing C-peptide levels, whereas HDL was inversely associated with fasting C-peptide concentration. A positive and negative correlation between atherogenic index (r xy = 0.36) and HDL level (r xy = -0.36) with C-peptide values was found. Differences of HDL, LDL and atherogenic index were, in particular, recorded between the groups below and above the reference range of C-peptide (p ≤ 0.001). Considerable differences (p ≤ 0.001) were also observed for the same lipoprotein characteristics between the groups above and within the C-peptide reference. Generally, the type of cholesterol is crucial for the evaluation of specific changes concerning the C-peptide range. Lipoprotein concentrations differ in relation to C-peptide -not only below and above the physiological range, but also inside and outside of it. Conclusions: Fasting levels of cholesterol, plasma glucose, and atherogenic index were strongly associated with fasting C-peptide levels in healthy individuals. Our data suggest that fasting C-peptide could serve as a biomarker for the early detection of metabolic syndrome and/or insulin resistance prior to the manifestation of type 2 diabetes.

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Is C-peptide a predictor of severity of coronary artery disease in metabolic syndrome? An observational study

Cited by 8 publications

References 11 publications

C-Peptide: A Mediator of the Association Between Serum Uric Acid to Creatinine Ratio and Non-Alcoholic Fatty Liver Disease in a Chinese Population With Normal Serum Uric Acid Levels

C-Peptide: A Mediator of the Association Between Serum Uric Acid to Creatinine Ratio and Non-Alcoholic Fatty Liver Disease in a Chinese Population With Normal Serum Uric Acid Levels

Relationship between Insulin Secretion and Arterial Stiffness in Essential Hypertension

Cholesterol and glucose profiles according to different fasting C-peptide levels: a cross-sectional analysis in a healthy cohort from the Czech Republic

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