Is Body Mass Index a prognostic factor of survival in colonic cancer? A multivariate analysis

Serrano, M.; Carrasco, Manel Armengol; Millán, Aránzazu Caballero; Ching, Christine D.; Cazador, Antoni Codina

doi:10.1016/s2173-5077(11)70020-5

Cited by 4 publications

(1 citation statement)

References 24 publications

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“…Obesity is clearly associated with the incidence of CRC [ 17 – 22 ], and the relationship between obesity and colorectal cancer has been previously reported but remains controversial. Several studies have reported that a high BMI is associated with a poor prognosis in patients with CRC [ 20 , 23 ], while other studies have reported that a high BMI is not related to prognosis [ 24 , 25 ] or is even related to a better prognosis [ 26 , 27 ]. This study explores the prognostic factors related to elderly patients with CRC after curative resection, and the results show that BMI ≥ 24 kg/m 2 (HR, 2.30, 95% CI, 1.27–4.17; P = 0.006) and N1-N2 stage (HR: 2.97; 95% CI, 1.48–5.97; P = 0.002) were independent prognostic factors affecting CSS.…”

Section: Discussionmentioning

confidence: 99%

The safety and prognosis of radical surgery in colorectal cancer patients over 80 years old

et al. 2023

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Objective The purpose of this study was to assess the safety and feasibility of radical surgery and to investigate prognostic factors influencing in colorectal cancer (CRC) patients over the age of 80. Methods Between January 2010 and December 2020, 372 elderly CRC patients who underwent curative resection at the National Cancer Center were enrolled in the study. Preoperative clinical characteristics, perioperative outcomes, and postoperative pathological features were all collected. Results A total of 372 elderly patients with colorectal cancer were included in the study, including 226 (60.8%) men and 146 (39.2%) women. A total of 219 (58.9%) patients had a BMI < 24 kg/m2, and 153 (41.1%) patients had a BMI ≥ 24 kg/m2. The mean operation time and intraoperative blood loss were 152.3 ± 58.1 min and 67.6 ± 35.4 ml, respectively. The incidence of overall postoperative complications was 28.2% (105/372), and the incidence of grade 3–4 complications was 14.7% (55/372). In the multivariable Cox regression analysis, BMI ≥ 24 kg/m2 (HR, 2.30, 95% CI, 1.27–4.17; P = 0.006) and N1-N2 stage (HR: 2.97; 95% CI, 1.48–5.97; P = 0.002) correlated with worse CSS. Conclusion The findings of this study showed that radical resection for CRC is safe and feasible for patients over the age of 80. After radical resection, BMI and N stage were independent prognostic factors for elderly CRC patients.

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Section: Discussionmentioning

confidence: 99%

The safety and prognosis of radical surgery in colorectal cancer patients over 80 years old

et al. 2023

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Évaluation du statut nutritionnel chez les patients présentant un glioblastome en récidive

et al. 2013

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Potential Biomarkers of Fat Loss as a Feature of Cancer Cachexia

Ebadi

Mazurak

2015

Mediators of Inflammation

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Fat loss is associated with shorter survival and reduced quality of life in cancer patients. Effective intervention for fat loss in cachexia requires identification of the condition using prognostic biomarkers for early detection and prevention of further depletion. No biomarkers of fat mass alterations have been defined for application to the neoplastic state. Several inflammatory cytokines have been implicated in mediating fat loss associated with cachexia; however, plasma levels may not relate to adipose atrophy. Zinc-α2-glycoprotein may be a local catabolic mediator within adipose tissue rather than serving as a plasma biomarker of fat loss. Plasma glycerol and leptin associate with adipose tissue atrophy and mass, respectively; however, no study has evaluated their potential as a prognostic biomarker of cachexia-associated fat loss. This review confirms the need for further studies to identify valid prognostic biomarkers to identify loss of fat based on changes in plasma levels of biomarkers.

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Is Body Mass Index a prognostic factor of survival in colonic cancer? A multivariate analysis

Cited by 4 publications

References 24 publications

The safety and prognosis of radical surgery in colorectal cancer patients over 80 years old

The safety and prognosis of radical surgery in colorectal cancer patients over 80 years old

Évaluation du statut nutritionnel chez les patients présentant un glioblastome en récidive

Potential Biomarkers of Fat Loss as a Feature of Cancer Cachexia

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