Is Blood Homocysteine Elevated in Migraine?

Hering-Hanit, Rachel; Gadoth, Natan; Yavetz, A.; Gavendo, S; Sela, Ben‐Ami

doi:10.1046/j.1526-4610.2001.01143.x

Cited by 49 publications

(42 citation statements)

References 14 publications

(18 reference statements)

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“…In this study, we did not examine which factors could lead to an elevation of homocysteine levels, only if the elevation itself was present. Regardless of the provoking factors, elevated total homocysteine concentration is an independent risk factor for recurrent stroke [38] which may result from an endothelial injury and altered coagulant properties of the blood [39, 40]; however, it is still controversial whether mild hyperhomocysteinemia is a causal factor. It has been found that migraine patients with aura who are homozygotes for methylene-tetrahydrofolate reductase (MTHFR) C677T variant, are at risk for elevated levels of homocysteine, and homocysteine-related endothelial dysfunction may be involved in the initiation and maintenance of migraine [21].…”

Section: Discussionmentioning

confidence: 99%

Risk factors of migraine-related brain white matter hyperintensities: an investigation of 186 patients

et al. 2011

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Brain white matter hyperintensities are more prevalent in migraine patients than in the general population, but the pathogenesis and the risk factors of these hyperintensities are not fully elucidated. The authors analyzed the routine clinical data of 186 migraine patients who were referred to the Outpatient Headache Department of the Department of Neurology, Medical School, University of Pécs, Hungary between 2007 and 2009: 58 patients with white matter hyperintensities and 128 patients without white matter hyperintensities on 3 T MRI. Significant associations between the presence of white matter hyperintensities and longer disease duration (14.4 vs. 19.9 years, p = 0.004), higher headache frequency (4.1 vs. 5.5 attacks/month, p = 0.017), hyperhomocysteinemia (incidence of hyperintensity is 9/9 = 100%, p = 0.009) and thyroid gland dysfunction (incidence of hyperintensity is 8/14 = 57.1%, p = 0.038) were found. These data support the theory that both the disease duration and the attack frequency have a key role in the formation of migraine-related brain white matter hyperintensities, but the effects of comorbid diseases may also contribute to the development of the hyperintensities.

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Section: Discussionmentioning

confidence: 99%

Risk factors of migraine-related brain white matter hyperintensities: an investigation of 186 patients

et al. 2011

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“…We are not aware of any other studies of homocysteine and migraine from population samples; three clinic-based studies that compared homocysteine levels in migraine patients to controls produced conflicting results. [15][16][17] Strengths of this study include our large, wellcharacterized, population-based cohort. Our migraine sufferers represent a range of severity and not just the presumably more severe phenotype seen in subspecialty care.…”

Section: Discussionmentioning

confidence: 99%

Migraine and MTHFR C677T genotype in a population‐based sample

Scher

Terwindt

Verschuren

et al. 2005

Annals of Neurology

192

160

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ObjectiveMigraine with aura is associated with increased risk of stroke. The MTHFR C677T genotype has been associated with increased risk of migraine in selected clinical samples and with elevated homocysteine, a risk factor for stroke. We assessed the association of the MTHFR C677T variant with migraine and the mediating effect of cardiovascular risk factors and metabolic markers of genotype status.MethodsWe compared adult migraineurs with aura (MA; n = 187), without aura (MO; n = 226), and nonmigraineurs (n = 1,212) from the population‐based Genetic Epidemiology of Migraine study.ResultsCompared with the wild‐type genotype, the T/T genotype was associated with increased odds of MA (odds ratio [OR], 2.05; 95% confidence interval, 1.2–3.4; p < 0.006), with a trend of increasing numbers of T alleles (OR, 1.40; 95% confidence interval, 1.1–1.8; p < 0.007). ORs were slightly attenuated after adjusting for homocysteine.InterpretationRisk of MA is associated with MTHFR C674T homozygosity, independent of other cardiovascular risk factors. Ann Neurol 2006

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“…The authors have not analysed blood homocysteine levels, but elevated serum levels of homocysteine have been reported in patients suffering of migraine with aura not in tension-type headache patients. Hering-Hanit et al [29] examined blood homocysteine in a significant number of patients with migraine but they did not find its levels augmented. To the best of our knowledge no study has been conducted on the possible correlation between blood homocysteine levels and migraine severity and on the possible role of hyperhomocysteinemia as a causative factor in the predisposition to migraine.…”

Section: Migraine and Genetic Polymorphismsmentioning

confidence: 99%

Migraine and Genetic Polymorphisms: An Overview

Pizza¹,

Agresta²,

Agresta³

et al. 2012

TONEUJ

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The relationship between genetic polymorphisms and migraine as a cause of an increased risk of thrombotic disorders development is still debated In this respect, factor V Leiden, factor V (H1299R), prothrombin G20210A, factor XIII (V34L), β-fibrinogen, MTHFR (C677T), MTHFR (A1298C), APO E, PAI-1, HPA-1 and ACE I/D seem to play a determinant role in vascular diseases related to migraine. The present review analyzes both the incidence of the above genetic vascular mutations in migraineurs and the most re-cent developments related to genetic polymorphisms and migraine.

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Is Blood Homocysteine Elevated in Migraine?

Abstract: Blood homocysteine is not elevated in migraine.

Cited by 49 publications

References 14 publications

Risk factors of migraine-related brain white matter hyperintensities: an investigation of 186 patients

Risk factors of migraine-related brain white matter hyperintensities: an investigation of 186 patients

Migraine and MTHFR C677T genotype in a population‐based sample

Migraine and Genetic Polymorphisms: An Overview

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