Is birth weight related to later glucose and insulin metabolism?—a systematic review

Newsome, C. A.; Shiell, A. W.; Fall, Caroline H.D.; Phillips, David I. W.; Shier, Rosie; Law, Catherine

doi:10.1046/j.1464-5491.2003.00871.x

Cited by 405 publications

(316 citation statements)

References 74 publications

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“…Our finding of a possible U-shaped association between birthweight and type 2 diabetes is in agreement with some studies [19,20], but most report an inverse relationship (reviewed in [3]). In agreement with Whincup et al (1997) [21], we found that the post-natal growth effect was stronger than the pre-natal effect indicated by birthweight.…”

Section: Discussionsupporting

confidence: 93%

“…Food rationing will also have reduced differences related to socio-economic status in maternal and childhood diets, compared with those differences in subjects born at other times [17]. Our finding that the relationship of early life growth with type 2 diabetes was largely accounted for by current adult BMI is in agreement with one study [18], but not with those of a later one [3]. It is, of course, possible that the processes that determine adiposity rebound occur in the antenatal period, but we have no data to investigate that.…”

Section: Discussionsupporting

confidence: 82%

“…The association between low birthweight and type 2 diabetes is well documented [1][2][3], and may reflect the continuation of changes in glucose and insulin metabolism that occur during slow growth in utero [4]. Eriksson et al (2003) showed that type 2 diabetes was not only strongly associated with poor prenatal growth, but also with early postnatal growth [5].…”

Section: Introductionmentioning

confidence: 98%

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Early growth and type 2 diabetes: evidence from the 1946 British birth cohort

et al. 2005

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Aims/hypothesis: We assessed whether low birthweight or early adiposity rebound was more strongly associated with type 2 diabetes, and whether any effect of low birthweight or early adiposity rebound was explained by adult BMI, adult height, social class of subject or of his/her father, or maternal or paternal diabetes. Methods: Cox's proportional hazard models were used on data from the National Birth Cohort Study (the MRC National Survey of Health and Development), which was begun in 1946 and had self-reported physician-diagnosed diabetes with age at onset ranging from 31 to 53 years (n=78 cases, and n=47 cases in the multivariate analysis) as the outcome. Results: A U-shaped association between birthweight and type 2 diabetes rates was close to statistical significance (quadratic term p value=0.08). Younger age at adiposity rebound was associated with increased rates of type 2 diabetes (test for trend p=0.002), the association being robust to adjustment for each of sex, birthweight, weight at 2 years, father's social class, parental diabetes, and own social class. The effect of early adiposity rebound was very slightly reduced by adjustment for sex and adult height (p=0.003), but considerably reduced after adjustment for sex and adult BMI (test for trend p=0.1), and further reduced (p=0.4) after additional adjustment for birthweight, weight at 2 years, adult height, social class of subject and of his/her father, and parental diabetes. Conclusions/interpretation: Early adiposity rebound was associated with an increased rate of type 2 diabetes independently of birthweight, but its effect was mostly through high adult BMI. Parental diabetes and possibly low weight at 2 years were also risks.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 98%

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Early growth and type 2 diabetes: evidence from the 1946 British birth cohort

et al. 2005

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“…Gupta et al found higher insulin resistance among Indian low BW children [28] whereas in the UK no association was observed in children [10,11]. Evidence that BW affects HOMA%b is inconclusive [12]. There are reports that low BW was associated with elevated HOMA%b [5], whereas others did not found an association [1,2,26].…”

Section: Interpretation Of the Findingsmentioning

confidence: 99%

“…However, some studies have reported that current adult BMI is associated with insulin resistance regardless of BW and postnatal growth [10,11]. Studies have also assessed the effect of these factors on insulin secretion but results are not consistent [1,5,12,13].…”

Section: Introductionmentioning

confidence: 99%

Birth weight, current body mass index, and insulin sensitivity and secretion in young adults in two Latin American populations

Silva

Santos

Amigo

et al. 2012

Nutrition, Metabolism and Cardiovascular Diseases

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Prediction From Low Birth Weight to Female Adolescent Depression

Costello¹,

Worthman²,

Erkanli³

et al. 2007

Arch Gen Psychiatry

213

143

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Context: Low birth weight (LBW) predicts later-onset hypertension and diabetes mellitus. Its role as a predictor of depression is unclear.Objectives: To examine whether LBW predicts depression in male and female children and adolescents and to compare the following 2 hypotheses: Low birth weight is one among several perinatal, childhood, and adolescent risk factors for depression (biopsychosocial hypothesis). Low birth weight is a marker for poor intrauterine conditions that provoke adjustments in fetal development, with long-term consequences for stress response (fetal programming hypothesis).Design: A representative population-based sample from an 11-county area in western North Carolina was assessed annually for psychiatric disorders between the ages of 9 and 16 years. We tested the prediction from LBW and depression in models that included LBW only, LBW plus other prenatal and perinatal adversities, LBW plus significant perinatal and childhood adversities, and LBW plus significant perinatal and childhood adversities and adolescent correlates.Setting: Academic research.Participants: There were 1420 participants, of whom 49% were female.Main Outcome Measure: Cumulative prevalence of DSM-IV depressive disorder at 1 assessment or more during childhood (age range, 9-12 years) and during adolescence (age range, 13-16 years). Results:The cumulative prevalence of depression among adolescent girls with LBW was 38.1% (95% confidence interval [CI], 16.3%-66.0%) compared with 8.4% (95% CI, 5.2%-13.3%) among adolescent girls with normal birth weight. Rates among children and adolescent boys did not exceed 4.9%. In adolescence, there was a significant interaction between LBW and sex (odds ratio, 0.2 [95% CI, 0.1-0.5]; PϽ.001). Low birth weight predicted female adolescent depression after controlling for other perinatal, childhood, and adolescent adversities. Girls with LBW and normal birth weight with no adversities had no adolescent depression, but each additional adversity increased the risk of in girls with LBW more than in girls with normal birth weight. Low birth weight did not predict other psychiatric disorders in either sex.Conclusions: Low birth weight predicts depression in adolescent girls but not boys. Data support fetal programming over the biopsychosocial hypothesis, suggesting vulnerability to adversities in girls with LBW after puberty.

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Is birth weight related to later glucose and insulin metabolism?—a systematic review

Abstract: The published literature shows that, generally, people who were light at birth have an adverse profile of later glucose and insulin metabolism. This is related to higher insulin resistance, but the relationship to insulin secretion in adults is less clear.

Cited by 405 publications

References 74 publications

Early growth and type 2 diabetes: evidence from the 1946 British birth cohort

Early growth and type 2 diabetes: evidence from the 1946 British birth cohort

Birth weight, current body mass index, and insulin sensitivity and secretion in young adults in two Latin American populations

Prediction From Low Birth Weight to Female Adolescent Depression

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