Is beryllium disease a fossil? - Not yet

Ratney, Ronald S.

doi:10.1007/s004200000205

Cited by 4 publications

(2 citation statements)

References 5 publications

(6 reference statements)

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“…By varying the sulfuric acid content, it is possible to verify whether the internal standard reacts in the same way as Be. Figure 1 shows the results for the internal standards used, and the linearity of the Be/Li signal clearly demonstrates that 6 Li showed the same pattern as 9 Be. This fact makes 6 Li the internal standard of choice for correcting the 9 Be signal.…”

Section: Choice Of Internal Standardmentioning

confidence: 89%

“…CBD is a progressive granulomatous lung disease that is characterized by mononuclear cell infiltration and granulomatous inflammation in the lungs (1,(3)(4)(5)(6). Be toxicity may depend upon particle properties including the number, concentration, or size of the particles, surface area, and chemical form (1,(7)(8)(9)(10)(11)(12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

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Development and Validation of Analytical Methods for Ultra-Trace Beryllium in Biological Matrices

Paquette¹,

Larivière²,

Cormier³

et al. 2010

Journal of Analytical Toxicology

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Beryllium (Be) is still not well understood from a toxicological point of view, and studies that involve the determination of different Be compounds species in tissues need to be conducted. In this paper we describe the development and validation of reliable methods for the detection of ultra-trace levels of Be in various biological matrices. Blood and tissues (liver, lung, spleen, and kidney) were used in this study. The samples were digested with a mixture of nitric and perchloric acids for Be and BeAl and an addition of sulfuric acid was made for BeO. The solutions were analyzed by inductively coupled plasma mass spectrometry with (6)Li as internal standard. The detection limits are in the order of 0.02 ng/g for tissue and 0.03 ng/mL for blood, and were compared to existing reference methods. To our knowledge, this is the first study that assesses dissolution of the different Be compounds in biological matrices, while also undergoing a rigorous optimization and complete validation. This method has proven that it is reliable, among the most sensitive available in the literature, and that it can be used in trace toxicological studies for Be.

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Section: Choice Of Internal Standardmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Development and Validation of Analytical Methods for Ultra-Trace Beryllium in Biological Matrices

Paquette¹,

Larivière²,

Cormier³

et al. 2010

Journal of Analytical Toxicology

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Beryllium and its inorganic compounds [BAT Value Documentation, 2005]

Schaller¹

2012

The MAK‐Collection for Occupational Health and Safety

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Published in the series BAT Value Documentations , Vol. 4 (2005) The article contains sections titled: Metabolism and Kinetics Absorption Toxicokinetics Elimination Critical Toxicity Exposure and Effects Relationship between external and internal exposure Relationship between internal exposure and effects Selection of the Indicators Methods Background Exposure Evaluation of Exposure Equivalents

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Beryllium und seine anorganischen Verbindungen [BAT Value Documentation in German language, 2003]

Schaller¹

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Biologische Arbeitsstoff‐Toleranz‐Werte (BAT‐Werte) und Expositionsäquivalente für krebserzeugende Arbeitsstoffe (EKA) , 11. Lieferung, Ausgabe 2003 Der Artikel enthält folgende Kapitel: Metabolismus und Kinetik Resorption Toxikokinetik Elimination Kritische Toxizität Belastung und eanspruchung Beziehung zwischen externer und interner Belastung Beziehung zwischen innerer Belastung und Beanspruchung Auswahl der Indikatoren Untersuchungsmethoden Hintergrundbelastung Evaluierung von Expositionsäquivalenten

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Is beryllium disease a fossil? - Not yet

Cited by 4 publications

References 5 publications

Development and Validation of Analytical Methods for Ultra-Trace Beryllium in Biological Matrices

Development and Validation of Analytical Methods for Ultra-Trace Beryllium in Biological Matrices

Beryllium and its inorganic compounds [BAT Value Documentation, 2005]

Beryllium und seine anorganischen Verbindungen [BAT Value Documentation in German language, 2003]

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