Is autologous platelet concentrate beneficial for post-extraction socket healing? A systematic review

Fabbro, Massimo Del; Bortolin, Monica; Taschieri, Silvio

doi:10.1016/j.ijom.2011.04.009

Cited by 109 publications

(126 citation statements)

References 58 publications

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“…The findings from our systematic review on the effect of plasma concentrates on postextraction healing are in line with those reported by others [24,25,26,27]. As in the previous reviews [24,25,26,27], the heterogeneity of the available primary studies did not allow to perform a quantitative analysis of the main clinical outcomes.…”

Section: Discussionsupporting

confidence: 86%

“…As in the previous reviews [24,25,26,27], the heterogeneity of the available primary studies did not allow to perform a quantitative analysis of the main clinical outcomes. These reviews reported that platelet concentrates may be beneficial in reducing postoperative pain, swelling, trismus, and inflammation, thereby improving quality of life and comfort in the early period after extraction, although the actual effect on decreasing pain is still not quantifiable [24,26,27]. They also highlighted that there is a beneficial effect of platelet concentrates on inducing and accelerating soft tissue healing after tooth extraction [25,27].…”

Section: Discussionmentioning

confidence: 99%

“…However, at the moment, there is no consensus on the real benefits of platelet concentrates in this indication, with only few papers being published on this topic showing heterogeneous and in some cases low methodological quality as pointed out in recent reviews [24,25,26,27]. …”

Section: Discussionmentioning

confidence: 99%

“…In contrast to other reviews [24,25,26], we decided to exclude studies on impacted third molars, due to the osteotomy of the socket walls that frequently is made in such extractions, and studies in which platelet concentrates were used in combination with bone grafts, trying to investigate only the platelet concentrate influence on the healing process. Unlike in other reviews [24,26], only studies involving healthy patients as well as patients not assuming any medication with possible effects on platelets or on bone metabolism were included, in order to limit the confounding variables and facilitate the interpretation of results. …”

Section: Discussionmentioning

confidence: 99%

“…They also highlighted that there is a beneficial effect of platelet concentrates on inducing and accelerating soft tissue healing after tooth extraction [25,27]. With regard to the effect on hard tissue, these reviews did show only limited evidence for or no effect on bone healing [24,25,27]. Only Del Fabbro et al [26], after performing a meta-analysis, came to the conclusion that the use of platelet concentrates can be advantageous for some relevant clinical and radiographic outcomes, such as soft tissue and bone healing after a dental extraction procedure.…”

Section: Discussionmentioning

confidence: 99%

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The Role of Autologous Platelet Concentrates in Alveolar Socket Preservation: A Systematic Review

Annunziata

Guida

Nastri

et al. 2018

Transfus Med Hemother

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Prevention of alveolar bone resorption after tooth extraction may be useful for implant rehabilitation of the edentulous site minimizing the future need for bone augmentation procedures. A number of studies have investigated the efficacy of autologous platelet concentrates for the preservation of the alveolar bone volume after tooth extraction. Although encouraging results have been published, the available data are still controversial. The aim of the present systematic review was to assess the effect of platelet concentrates on alveolar socket preservation after tooth extraction. A literature search was carried out up to September 2017 for prospective controlled trials in which a test group using exclusively a platelet concentrate was compared with a control group in which extraction sockets were left to heal spontaneously. Seven controlled clinical trials published between 2010 and 2016 were included. A total of 320 extractions (170 tests and 150 controls) in 190 patients was considered. A great heterogeneity was found in terms of study design, methodological aspects, and outcome evaluation. For this reason, a quantitative analysis followed by meta-analysis was not possible, and only a descriptive analysis on the role of platelet concentrates in alveolar socket preservation was carried out. There is growing evidence that platelet concentrates may be advantageously used in postextraction sites, mainly to improve soft tissue healing and to reduce postoperative symptoms. Data about their potential in preserving the alveolar bone volume are still scarce and controversial, although recently encouraging results have been presented using more reliable and accurate evaluation technologies, such as the computed tomography. Further, well-designed and methodologically standardized investigations are strongly demanded to reach a higher level of evidence on this topic.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

The Role of Autologous Platelet Concentrates in Alveolar Socket Preservation: A Systematic Review

Annunziata

Guida

Nastri

et al. 2018

Transfus Med Hemother

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Autologous Intraoral Block Bone Grafting for Augmentation of Severe Atrophic MaxillaAdvantages of Combined Therapy

Schwartz‐Arad¹

2016

Horizontal Alveolar Ridge Augmentation in Implant Dentistry: A Surgical Manual

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Efficacy of intralesional injections of platelet‐rich plasma in patients with oral lichen planus: A pilot randomized clinical trial

Hijazi

Ahmed

Gaafar

2022

Clinical & Exp Dental Res

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Objective: To evaluate the clinical efficacy of intralesional platelet-rich plasma (PRP) injections compared to intralesional triamcinolone acetonide (TA) injections in the treatment of erosive oral lichen planus (EOLP).Material and Methods: Twenty patients with EOLP were assigned randomly to either PRP or TA group. Patients received weekly intralesional injections for 4 weeks, and then followed up for 3 months on regular visits every 2 weeks. Pain scores using numerical pain score and clinical score were recorded by a blinded assessor each visit for all patients and remission score at the end of the trial was recorded.Results: Both groups showed significant improvement in the clinical parameters (pain and clinical score) "p = .001." Regarding remission of the lesions, 80% of patients in the PRP group showed complete remission compared to 70% in the TA group. However, there is no statistical significance when comparing the two groups in pain score, clinical score, or remission.Conclusions: PRP injections could be considered as an effective alternative single treatment modality for EOLP. The protocol for this study registered in Clinicaltrials.gov registry under the identifier number: NCT03293368.

show abstract

Is autologous platelet concentrate beneficial for post-extraction socket healing? A systematic review

Cited by 109 publications

References 58 publications

The Role of Autologous Platelet Concentrates in Alveolar Socket Preservation: A Systematic Review

The Role of Autologous Platelet Concentrates in Alveolar Socket Preservation: A Systematic Review

Autologous Intraoral Block Bone Grafting for Augmentation of Severe Atrophic MaxillaAdvantages of Combined Therapy

Efficacy of intralesional injections of platelet‐rich plasma in patients with oral lichen planus: A pilot randomized clinical trial

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