Is autologous cord blood transfusion effective and safe in preterm infants?

Yavuz, Beril Altaş; Okulu, Emel; Arsan, Saadet; Akın, İlke Mungan; Atasay, Begüm; Erdeve, Ömer

doi:10.24953/turkjped.2017.03.022

Cited by 4 publications

(4 citation statements)

References 21 publications

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“…Several authors suggested the possibility of using cord blood as an alternative to adult blood transfusion . We reported four case reports and thirteen case series .…”

Section: Review Of Studies On Umbilical Cord Blood As a Source For Trmentioning

confidence: 99%

“…Several authors suggested the possibility of using cord blood as an alternative to adult blood transfusion . We reported four case reports and thirteen case series . Transfusions were performed because of neonatal anaemia in seven cases , surgical indications such as congenital malformations and cardiac surgeries in eight cases.…”

Section: Review Of Studies On Umbilical Cord Blood As a Source For Trmentioning

confidence: 99%

“…We reported four case reports and thirteen case series . Transfusions were performed because of neonatal anaemia in seven cases , surgical indications such as congenital malformations and cardiac surgeries in eight cases. Two papers reported an experience in both anaemic and surgical patients .…”

Section: Review Of Studies On Umbilical Cord Blood As a Source For Trmentioning

confidence: 99%

“…Two papers reported an experience in both anaemic and surgical patients . Cord blood was collected in preterm , term neonates as well as in both . The rate of transfusion is quite wide, ranging from 2·3 to 100% of enrolled patients with a great variability of the median volume of cord blood collected (Table ).…”

Section: Review Of Studies On Umbilical Cord Blood As a Source For Trmentioning

confidence: 99%

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Umbilical cord blood as a source for red‐blood‐cell transfusion in neonatology: a systematic review

et al. 2018

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The prevention and treatment of anaemia in newborn patients made tremendous progress in the last decades. However, red-blood-cell (RBC) transfusions remain unavoidable in many neonates candidate to surgery and especially in preterm infants. In particular, anaemia occurring in neonates born at extremely low gestational age is actually severe and frequently requires transfusions. Several approaches have been explored to prevent or even to reduce the threshold and the frequency of RBC transfusions. Among these, umbilical cord blood (UCB) collection and processing to obtain RBC components for autologous or allogeneic transfusion have been extensively investigated. In this systematic review, we revised the literature concerning the use of UCB for either autologous or allogeneic transfusion purposes and we illustrated the rationale for a transfusion therapy tailored to extremely preterm neonates, based on RBC concentrates from allogeneic UCB donations.

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“…Several authors suggested the possibility of using cord blood as an alternative to adult blood transfusion . We reported four case reports and thirteen case series .…”

Section: Review Of Studies On Umbilical Cord Blood As a Source For Trmentioning

confidence: 99%

Section: Review Of Studies On Umbilical Cord Blood As a Source For Trmentioning

confidence: 99%

Section: Review Of Studies On Umbilical Cord Blood As a Source For Trmentioning

confidence: 99%

Section: Review Of Studies On Umbilical Cord Blood As a Source For Trmentioning

confidence: 99%

See 2 more Smart Citations

Umbilical cord blood as a source for red‐blood‐cell transfusion in neonatology: a systematic review

et al. 2018

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Umbilical cord blood: Current uses for transfusion and regenerative medicine

Orlando

Pellegrino

Valentini

et al. 2020

Transfusion and Apheresis Science

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Autologous umbilical cord blood for red cell concentrate transfusion in preterm infants in the era of delayed cord clamping: An uncontrolled clinical trial

Abiramalatha

Radhakrishnan

Panicker

et al. 2020

Transfusion Medicine

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Objective: To assess the utility of autologous umbilical cord blood (UCB) for red cell concentrate (RCC) transfusion in preterm infants. Methods: We recruited preterm infants born at ≤30 weeks' gestation or have an estimated fetal weight <1,200 g. We intended to perform delayed cord clamping (DCC) and to collect UCB following DCC. The quality parameters used included blood culture performed once, and biochemical and haematological parameters assessed weekly. Results: Of the 46 recruited neonates, DCC could be performed for 1 minute in 11 (23.9%) and for 30-59 seconds in 10 (21.7%) infants. The success rate of UCB collection was significantly lower in infants who underwent DCC for 1 minute (27%) compared to those who underwent DCC for 30-59 seconds (70%) or immediate cord clamping (72%) (p value 0.031). Twenty-five UCBs were stored after eliminating three that had positive culture. UCB had satisfactory quality for transfusion from day 3 (when blood culture report was available) to 14 (after which pH decreased to <6.5). Thirteen infants required 27 RCC transfusions. Autologous UCB could be used for only five (18.5%) transfusions. Conclusion: The success rate of UCB collection after DCC for 1 minute is low. Autologous UCB meets less than one-fifth of transfusion requirements. Hence, autologous UCB transfusion is not a workable option in preterm infants.

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Is autologous cord blood transfusion effective and safe in preterm infants?

Cited by 4 publications

References 21 publications

Umbilical cord blood as a source for red‐blood‐cell transfusion in neonatology: a systematic review

Umbilical cord blood as a source for red‐blood‐cell transfusion in neonatology: a systematic review

Umbilical cord blood: Current uses for transfusion and regenerative medicine

Autologous umbilical cord blood for red cell concentrate transfusion in preterm infants in the era of delayed cord clamping: An uncontrolled clinical trial

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