Is atrial natriuretic peptide important in the circadian rhythm of arterial blood pressure?

Colantonio, D; Pasqualetti, P; Casale, R; Natali, G

doi:10.1016/0002-9149(89)90105-7

Cited by 17 publications

(7 citation statements)

References 11 publications

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“…The results are in agreement with our previously re ported data [2][3][4], which demonstrated a sta tistically significant circadian rhythm, evalu ated by cosinor method, for plasma ANP circulating levels in healthy subjects, main tained both in standardized [3,4] and nonstandardized [2] life conditions. The acrophase of ANP occurred at 1.00 (from 23.00 to 4.00), and the amplitude was about of 30% of mesor.…”

supporting

confidence: 92%

“…The acrophase of ANP occurred at 1.00 (from 23.00 to 4.00), and the amplitude was about of 30% of mesor. Moreover, the maximum val ues of arterial blood pressure (ABP) were in antiphase with respect to the peak of circu lating ANP levels [3,4], Consequently, our data and those of Portaluppi et al [1] sup port the evidence of a definite circadian rhythm of ANP in normal subjects, without interference due to postural changes. These data suggest an inverse relationship between the circadian rhythm of ANP and the circa dian rhythm of ABP, mediated by the effects of ANP on the renin-angiotensin-aldosterone system.…”

supporting

confidence: 67%

“…These data suggest an inverse relationship between the circadian rhythm of ANP and the circa dian rhythm of ABP, mediated by the effects of ANP on the renin-angiotensin-aldosterone system. In fact, we have demonstrated that the secretion of ANP, renin, and aldo sterone seems to have a chronologic se quence [3,4], The increase in secretion of ANP. principally due to the increase in ve nous return during the night, determines lower levels of plasma renin activity (PRA) and plasma aldosterone (PA), by an in creased natriuresis and direct inhibition of secretion of renin and aldosterone [5].…”

mentioning

confidence: 99%

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Letter to the Editor

Colantonio¹,

Pasqualetti²

1990

Cardiology

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supporting

confidence: 92%

supporting

confidence: 67%

mentioning

confidence: 99%

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Letter to the Editor

Colantonio¹,

Pasqualetti²

1990

Cardiology

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“…Atenolol therapy significantly increased plasma ANP levels and urinary catecholamine excretion. Atenolol administration decreased PRA and PA values both on day 3 and on day 7. Nifedipine treatment increased PRA, PA, and urinary catecholamine levels significantly only on day 7 of therapy; plasma levels of ANP were not modified by nifedipine treatment.…”

Section: Resultsmentioning

confidence: 92%

Short‐Term Effects of Atenolol and Nifedipine on Atrial Natriuretic Peptide, Plasma Renin Activity, and Plasma Aldosterone in Patients with Essential Hypertension

Colantonio

Casale

Desiati³

et al. 1991

The Journal of Clinical Pharma

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The short-term effects of atenolol and nifedipine on plasma levels of atrial natriuretic peptide (ANP), plasma renin activity (PRA), and plasma aldosterone (PA) were studied in two groups of patients with uncomplicated essential hypertension. Urinary catecholamines, and sodium and potassium excretion were also studied. A group of 20 patients with hypertension, after a wash-out period of at least 10 days, was randomly subdivided into two protocol therapy subgroups. One group (six men and four women) received atenolol (100 mg/d), and the other group (six men and four women) received nifedipine (30 mg/d). Circulating plasma levels of ANP, PRA, and PA were determined by radioimmunoassay, and other variables were determined by routine laboratory techniques before therapy and at day 3 and day 7 after the treatment began. Arterial blood pressure and heart rate were monitored during the study. Both drugs reduced arterial blood pressure (P less than .001) significantly. The atenolol therapy decreased heart rate (P less than .001), increased plasma ANP levels and urinary catecholamine excretion, and decreased PRA and circulating PA levels. Nifedipine treatment did not modify plasma ANP values, whereas it increased PRA and PA circulating levels and urinary catecholamine excretion. No differences were shown for urinary volume, urinary sodium, and potassium excretions during the two different treatments. These findings suggest that the increased plasma ANP levels could contribute to the antihypertensive effects of the beta-adrenoreceptor blockers, by a reduction in PRA and PA levels and a vasodilatative effect.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…Factors that influence BP and show a circadian rhythm include the sympatho-adrenal system, the hypothalamo-pituitary-adrenal axis, the reninangiotensin-aldosterone system (22), and atrial natriuretic peptide (23). Although not specifically tested, it is possible that a significant number of subjects in our study had a degree of autonomic neuropathy, given the prevalence of this problem in diabetic subjects (24).…”

mentioning

confidence: 98%