Is ascites CEA a risk factor for peritoneal carcinomatosis in colorectal cancer?: a long-term follow-up study

Kim, Byung Chul; Bae, Jung Hoon; Park, Sun Min; Won, Dae; Lee, In Kyu

doi:10.1007/s00384-019-03448-2

Cited by 8 publications

(8 citation statements)

References 28 publications

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“…Four studies [48,[53][54][55], including data on 9639 patients (158 metachronous pmCRC, 9481 non-pmCRC) regarding histology, were included in the meta-analysis. The pooled analysis indicated that mucinous adenocarcinoma was positively associated with metachronous PM compared with nonmucinous adenocarcinoma (OR 4.175; 95% CI 1.798-9.692; P = 0.001) (Figure 4c).…”

Section: Histologymentioning

confidence: 99%

“…Two studies [48,54], including data on 2009 patients (79 metachronous pmCRC, 1930 non-pmCRC) regarding the surgical approach, were included in the meta-analysis. Metachronous PM were not associated with the laparoscopic approach (OR 0.571; 95% CI 0.310-1.052; P = 0.072) (Figure S2c).…”

Section: Laparoscopicapproachmentioning

confidence: 99%

“…Five studies [20,48,54,56,57], including data on 4672 patients (247 metachronous pmCRC, 4425 non-pmCRC) comparing differentiation grade, were included in the meta-analysis. The pooled analysis indicated that poorly differentiated grade was positively associated with metachronous PM compared with well/moderately differentiated grade (OR 2.291; 95% CI 1.603-3.275; P < 0.001) (Figure S1a).…”

Section: Differentiationgradementioning

confidence: 99%

“…Six studies [20,37,41,48,54,56], including data on 5602 patients (256 metachronous pmCRC, 5346 non-pmCRC) regarding tumour invasion depth, were included in the meta-analysis. The pooled analysis indicated that T4 was positively associated with metachronous PM compared with T1-3 (OR 2.897; 95% CI 1.248-6.726; P = 0.013) (Figure S1b).…”

Section: Tumourinvasiondepthmentioning

confidence: 99%

“…(b) Perforation (n = 6669; P = 0.014; Cochran Q 7.8, 6 df, P = 0.250; I 2 = 23.4) [6,37,47,48,50-52]. (c) MC (n = 9639; P = 0.001; Cochran Q 8.0, 3 df, P = 0.044; I 2 = 62.8)[48,[53][54][55]…”

mentioning

confidence: 99%

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Risk factors for developing peritoneal metastases after curative surgery for colorectal cancer: A systematic review and meta‐analysis

et al. 2021

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Aim: Proactive detection and treatment strategies have achieved encouraging survival outcomes for patients with early peritoneal metastases (PM), but these costly and invasive approaches can only be applied to selected high-risk patients. This meta-analysis aimed to identify the risk factors for metachronous PM after curative surgery for colorectal cancer (CRC). Method:The study was registered at PROSPERO (CRD42020219187). Databases were searched for studies comparing clinical and histopathological characteristics between patients with metachronous peritoneal metastases from colorectal cancer (pmCRC) and patients without (non-pmCRC).Results:Thirtysix studies were included. Metachronous PM were positively associated

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Section: Histologymentioning

confidence: 99%

Section: Laparoscopicapproachmentioning

confidence: 99%

Section: Differentiationgradementioning

confidence: 99%

Section: Tumourinvasiondepthmentioning

confidence: 99%

mentioning

confidence: 99%

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Risk factors for developing peritoneal metastases after curative surgery for colorectal cancer: A systematic review and meta‐analysis

et al. 2021

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Use of ascitic CEA levels as a predictive value for distant metastasis in high-risk stage II and III colorectal cancer

Al-Sawat

Bea

Han

et al. 2021

Int J Colorectal Dis

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Evaluation of peritoneal Carcinoembryonic Antigen as a survival prognostic factor in gastric cancer patients: a single western center experience

et al. 2023

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The aim of this study is to define the importance of peritoneal CEA (pCEA) as a prognostic factor of overall survival (OS) and disease-free survival (DFS) in gastric cancer (GC) patients surgically treated with a curative intent In our department. A total of 64 patients affected by gastric cancer with intraoperatively measurement of CEA on peritoneal lavage were enrolled in the study. Patients were divided into two groups: (A) the peritoneal lavage CEA ( −) with CEA < 0.5 ng/ml and (B) the peritoneal lavage CEA ( +) with CEA ≥ 0.5 ng/ml. Then we analyzed OS and DFS of the two groups correlating them to others clinico-pathological features. Furthermore, we investigated the correlation between pCEA and peritoneal cytology. We demonstrated a strong significant difference in OS and in DFS in CEA ( +) patients. We emphasized that pCEA had a strong survival impact, in both OS and DFS, in selected patients affected by diffuse histotype GC (p = 0.0048 and p = 0.0030 respectively), stage III (p = 0.015 and p = 0.021, respectively) and distal gastric cancer (p = 0.0036 and p = 0.0017, respectively). There is a strong need to recognize prognostic factors that can help clinicians to stratify patients at high risk to develop post-surgical recurrences and moreover to recognize who could benefit from an aggressive surgical treatment of cytoreductive surgery and intra-peritoneal chemotherapy.pCEA is a good predictor of survival in advanced gastric cancer and could discriminate which patients need a more accurate follow-up program and an intensive therapeutic strategy.

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Is ascites CEA a risk factor for peritoneal carcinomatosis in colorectal cancer?: a long-term follow-up study

Cited by 8 publications

References 28 publications

Risk factors for developing peritoneal metastases after curative surgery for colorectal cancer: A systematic review and meta‐analysis

Risk factors for developing peritoneal metastases after curative surgery for colorectal cancer: A systematic review and meta‐analysis

Use of ascitic CEA levels as a predictive value for distant metastasis in high-risk stage II and III colorectal cancer

Evaluation of peritoneal Carcinoembryonic Antigen as a survival prognostic factor in gastric cancer patients: a single western center experience

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