Is Arsenic Exposure a Risk Factor for Metabolic Syndrome? A Review of the Potential Mechanisms

Pánico, Pablo; Velasco, Manuel; Salazar, Ana Marı́a; Picones, Arturo; Ortiz-Huidobro, Rosa Isela; Guerrero-Palomo, Gabriela; Salgado-Bernabé, Manuel Eduardo; Ostrosky‐Wegman, Patricia; Hiriart, Marcia

doi:10.3389/fendo.2022.878280

Cited by 18 publications

(4 citation statements)

References 241 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Areas with high concentrations of drinking arsenic tend to have a high prevalence of hypertension [ 27 ]. Arsenic exposure could contribute to the multifactorial origin of metabolic syndrome pathology such as dyslipidemias [ 28 ]. In this study, the association between urinary arsenic and TC and LDL-C was studied by using urinary arsenic biomarker assessment of arsenic exposure based on NHANES population survey data from 2003 to March 2020.…”

Section: Discussionmentioning

confidence: 99%

Linking the Low-Density Lipoprotein-Cholesterol (LDL) Level to Arsenic Acid, Dimethylarsinic, and Monomethylarsonic: Results from a National Population-Based Study from the NHANES, 2003–2020

Huang

2022

Nutrients

View full text Add to dashboard Cite

Arsenic (As) contamination is a global public health problem. Elevated total cholesterol (TC) and low-density lipoprotein-cholesterol (LDL-C) are risk factors for cardiovascular diseases, but data on the association of urinary arsenic species’ level and LDL-C are limited. We performed an association analysis based on urinary arsenic species and blood TC and LDL-C in US adults. Methods: Urinary arsenic, arsenic acid (AA), dimethylarsinic (DMA), monomethylarsonic (MMA), TC, LDL-C, and other key covariates were obtained from the available National Health and Nutrition Examination Survey (NHANES) data from 2003 to 2020. Multiple linear regression analysis and generalized linear model are used to analyze linear and nonlinear relationships, respectively. Results: In total, 6633 adults aged 20 years were enrolled into the analysis. The median total urinary arsenic level was 7.86 µg/L. A positive association of urinary arsenic concentration quartiles was observed with TC (β: 2.42 95% CI 1.48, 3.36). The OR for TC of participants in the 80th versus 20th percentiles of urinary total arsenic was 1.34 (95% CI 1.13, 1.59). The OR for LDL-C of participants in the 80th versus 20th percentiles of urinary total arsenic was 1.36 (95% CI 1.15, 1.62). For speciated arsenics analysis, the OR for arsenic acid and TC was 1.35 (95% CI 1.02, 1.79), whereas the OR for DMA and LDL-L was 1.20 (95% CI 1.03, 1.41), and the OR for MMA and LDL-L was 1.30 (95% CI 1.11, 1.52). Conclusions: Urinary arsenic and arsenic species were positively associated with increased LDL-C concentration. Prevention of exposure to arsenic and arsenic species maybe helpful for the control of TC and LDL-C level in adults.

show abstract

Section: Discussionmentioning

confidence: 99%

Linking the Low-Density Lipoprotein-Cholesterol (LDL) Level to Arsenic Acid, Dimethylarsinic, and Monomethylarsonic: Results from a National Population-Based Study from the NHANES, 2003–2020

Huang

2022

Nutrients

View full text Add to dashboard Cite

show abstract

“…Long-term exposure to iAs can lead to the development of several health conditions such as skin lesions, peripheral neuropathy, cancer, or diabetes [ 90 ]. In relation to obesity, iAs has shown unconclusive results in both epidemiological and animal studies, and the potential mechanisms are not entirely understood [ 91 , 92 ]. However, because iAs can cross the placental barrier, it has been suggested that it could cause several physiological and epigenetic changes that may contribute to obesity development in the offspring [ 93 ].…”

Section: Inorganic Arsenicmentioning

confidence: 99%

Inherited Epigenetic Hallmarks of Childhood Obesity Derived from Prenatal Exposure to Obesogens

Núñez‐Sánchez

Jiménez-Méndez

Suárez-Cortés

et al. 2023

IJERPH

View full text Add to dashboard Cite

Childhood obesity has reached epidemic levels in developed countries and is becoming a major cause for concern in the developing world. The causes of childhood obesity are complex and multifactorial, involving the interaction between individual genetics and environmental and developmental factors. Among the environmental factors, there is a growing interest in understanding the possible relationship between the so-called environmental obesogens and the development of obesity in children. Exposure to these obesogens such as phthalates, bisphenol A, or parabens, has been identified as a promoter of obesity through different mechanisms such as the alteration of adipocyte development from mesenchymal progenitors, the interference with hormone receptors, and induced inflammation. However, less attention has been paid to the inheritance of epigenetic modifications due to maternal exposure to these compounds during pregnancy. Thus, the aim of this review is to summarize the current knowledge of epigenetic modifications due to maternal exposure to those obesogens during pregnancy as well as their potential implication on long-term obesity development in the offspring and transgenerational inheritance of epiphenotypes.

show abstract

“…High arsenic is found in groundwater in parts of the United States, Chile, Mexico, China, Argentina, India, and Bangladesh 1 , where inorganic arsenic exposure is reported to be associated with cancers, cardiovascular diseases, neurological diseases, and arsenic-related skin lesions (ArSL) including hyperkeratosis, skin cancers, and pigmentary changes [2][3][4] . Even in low-exposure populations (water arsenic <1 μg/L) in the US, rice consumption was associated with higher risk of squamous cell carcinoma of skin 5 .…”

Section: Introductionmentioning

confidence: 99%

Arsenic exposure and pruritus: evidence from observational, interventional, and Mendelian randomization studies

Xiaoyan

Xiao

Jing

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: Pruritus has been reported as an adverse drug reaction to arsenic trioxide, but the association of arsenic exposure with pruritus has not been systematically investigated. To investigate the association of arsenic exposure with pruritus, we performed observational, interventional, and Mendelian randomization studies. Methods: A cross-sectional study was conducted in Shimen, China. A Mendelian randomization study was conducted to confirm the causal relationship between susceptibility to arsenic toxicity, in terms of genetically predicted percentages of monomethylated arsenic (MMA%) and dimethylated arsenic (DMA%) in urine, and chronic pruritus in the UK Biobank participants. Then, a case-control study in Shimen participants was conducted to determine the biomarker for pruritus, and arsenite-treated mice were used to confirm the biomarker. Last, a randomized, double-blind, placebo-controlled trial was conducted to test the efficacy of naloxone, a μ-opioid receptor antagonist, in arsenic-exposed patients with pruritus in Shimen. Results: Hair arsenic showed a dose-response relationship with the intensity of itch in 1092 participants. The Mendelian randomization analysis confirmed the causal relationship in the UK Biobank participants, with odds ratios of 1.043 for MMA% and 0.904 for DMA% above versus under median. Serum β-endorphin was identified as a significant biomarker associated with the intensity of itch. Consistently, treatment with arsenite in mice upregulated the level of β-endorphin. The randomized controlled trial showed that treatment with sublingual naloxone significantly relieved the intensity of itch in arsenic-exposed participants. Conclusion: Arsenic exposure is associated with pruritus, and β-endorphin serves as a biomarker of pruritus. Naloxone relieves pruritus in patients with [arseniasis](javascript:;).

show abstract

Is Arsenic Exposure a Risk Factor for Metabolic Syndrome? A Review of the Potential Mechanisms

Cited by 18 publications

References 241 publications

Linking the Low-Density Lipoprotein-Cholesterol (LDL) Level to Arsenic Acid, Dimethylarsinic, and Monomethylarsonic: Results from a National Population-Based Study from the NHANES, 2003–2020

Linking the Low-Density Lipoprotein-Cholesterol (LDL) Level to Arsenic Acid, Dimethylarsinic, and Monomethylarsonic: Results from a National Population-Based Study from the NHANES, 2003–2020

Inherited Epigenetic Hallmarks of Childhood Obesity Derived from Prenatal Exposure to Obesogens

Arsenic exposure and pruritus: evidence from observational, interventional, and Mendelian randomization studies

Contact Info

Product

Resources

About