Is Aortic Z-score an Appropriate Index of Beneficial Drug Effect in Clinical Trials in Aortic Aneurysm Disease?

Elkinany, Sherif; Weismann, Constance G.; Curtis, Alexander; Smith, Tanya; Zafar, Mohammad A.; Breen, Thomas; Li, Yupeng; Tranquilli, Maryann; Rizzo, John A.; Mukherjee, Sandip; Ziganshin, Bulat A.; Elefteriades, John A.

doi:10.1016/j.amjcard.2020.12.025

Cited by 2 publications

(2 citation statements)

References 23 publications

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“…Then there was no correlation between age and aortic dilatation. We selected patients younger than one year old as the subjects in this study, which was determined by the actual overall age characteristics of our patients, and there is a certain correlation between age and z score [ 28 ] . Finally, we analyzed the complexity of CoA and found that it was not related to aortic dilatation.…”

Section: Discussionmentioning

confidence: 99%

Application of Computed Tomography Angiography in Preoperative Diagnosis of Coarctation of Aorta and Evaluation of Aortic Dilatation in Infants

Xiao,

Lin,

Zheng

et al. 2024

Braz J Cardiovasc Surg

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Section: Discussionmentioning

confidence: 99%

Application of Computed Tomography Angiography in Preoperative Diagnosis of Coarctation of Aorta and Evaluation of Aortic Dilatation in Infants

Xiao,

Lin,

Zheng

et al. 2024

Braz J Cardiovasc Surg

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“…In order to minimize this bias, we did not use both methods in the same patient. Also, possible misleading interpretation of Z-scores in children with Marfan syndrome has been discussed in a recent study by Elkinany et al [ 44 ]. As the Z-score is naturally changing even in the absence of any aneurysmal pathology or medical intervention it may decrease spontaneously even in untreated Marfan patients.…”

Section: Discussionmentioning

confidence: 99%

Magnetic resonance angiography derived predictors of progressive dilatation and surgery of the aortic root in Marfan syndrome

et al. 2022

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Background To identify magnetic resonance (MR) angiography derived predictors of progressive dilatation and surgery of the aortic root in Marfan syndrome. Material and methods We retrospectively included 111 patients (32.7±16.5 years, range: 7–75 years) with a total of 446 MR angiographies. Aortic diameter growth rates of the entire thoracic aorta and Z-scores were estimated from annual diameter measurements. Aortic root shape was subdivided into three different types: (T0) normal; (T1) localized dilatation; (T2) generalized aortic root dilatation. Aortic diameter, Z-score, age, and aortic root shape at baseline were tested as predictors of aortic root dilatation using a multivariate logistic regression model. Results The highest aortic growth rate was observed at the level of the sinuses of Valsalva. Higher aortic root diameters and Z-scores at baseline predicted an increased growth of the aortic root (p = 0.003 and p<0.001). Young age (<30 years) was a predictor for the increase of Z-scores when compared to patients ≥30 years (p = 0.019). 25/111 patients (22.5%) had a T0 aortic root shape, 59/111 patients (53.2%) had a T1 aortic root shape, and 27/111 patients (24.3%) had a T2 aortic root shape. Aortic root shape did not predict further aortic growth (p>0.05). However, significantly more patients undergoing surgery had a generalized aortic dilatation (19/28, 76.9%) than a localized aortic root dilatation (9/28, 32.1%) (p = 0.001). Conclusion Larger baseline aortic root diameter and Z-score as well as young age predict solely progressive aortic root dilatation in Marfan patients. MR angiography derived type of aortic root shape does not predict aortic growth, but patients with generalized aortic root dilatation are referred more frequently for aortic surgery.

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Is Aortic Z-score an Appropriate Index of Beneficial Drug Effect in Clinical Trials in Aortic Aneurysm Disease?

Cited by 2 publications

References 23 publications

Application of Computed Tomography Angiography in Preoperative Diagnosis of Coarctation of Aorta and Evaluation of Aortic Dilatation in Infants

Application of Computed Tomography Angiography in Preoperative Diagnosis of Coarctation of Aorta and Evaluation of Aortic Dilatation in Infants

Magnetic resonance angiography derived predictors of progressive dilatation and surgery of the aortic root in Marfan syndrome

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