1998
DOI: 10.1093/humrep/13.11.2984
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Is antioxidant therapy a promising strategy to improve human reproduction? Are anti-oxidants useful in the treatment of male infertility?

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Cited by 20 publications
(4 citation statements)
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“…However, the positive effects of antioxidants are still debatable. Multiple studies have found no improvement following antioxidant intake (Agarwal et al, 2004; Ford and Whittington, 1998; Martin‐Du Pan and Sakkas, 1998; Moilanen and Hovatta, 1995; Rolf et al, 1999).…”
Section: Strategies For Os Preventionmentioning
confidence: 99%
“…However, the positive effects of antioxidants are still debatable. Multiple studies have found no improvement following antioxidant intake (Agarwal et al, 2004; Ford and Whittington, 1998; Martin‐Du Pan and Sakkas, 1998; Moilanen and Hovatta, 1995; Rolf et al, 1999).…”
Section: Strategies For Os Preventionmentioning
confidence: 99%
“…A recent prospective randomized study using a direct evaluation of sperm DNA fragmentation by TUNEL assay (Greco et al, 2005b) has confirmed these findings. However, some reports questioned the usefulness of antioxidants in the treatment of male infertility (Martin-Du Pan and Sakkas, 1998;Bolle et al, 2002;Agarwal et al, 2004), and in-vitro effects of antioxidants on sperm DNA integrity are inconsistent (Hughes et al, 1998;Donnelly et al, 1999). To our knowledge, no evaluation of the effect of oral antioxidant treatment on ICSI clinical outcomes in cases with elevated sperm DNA damage has yet been reported.…”
Section: Introductionmentioning
confidence: 99%
“…Numerous clinical trials have investigated the potential role of antioxidant therapy to relieve ROS-induced male factor infertility [23]. Although antioxidants are hypothesized to be useful therapeutic agents for male infertility, the results of clinical trials are controversial [23,24]. In this study, we investigated the patterns of antioxidant use among infertile male patients in Jordan.…”
Section: Discussionmentioning
confidence: 99%