Is antioxidant therapy a promising strategy to improve human reproduction? Are anti-oxidants useful in the treatment of male infertility?

Pan, R C Martin Du; Sakkas, Denny

doi:10.1093/humrep/13.11.2984

Cited by 20 publications

(4 citation statements)

References 24 publications

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“…However, the positive effects of antioxidants are still debatable. Multiple studies have found no improvement following antioxidant intake (Agarwal et al, 2004; Ford and Whittington, 1998; Martin‐Du Pan and Sakkas, 1998; Moilanen and Hovatta, 1995; Rolf et al, 1999).…”

Section: Strategies For Os Preventionmentioning

confidence: 99%

Prevention of Oxidative Stress Injury to Sperm

Agarwal

Prabakaran

Said

2005

Journal of Andrology

244

132

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Section: Strategies For Os Preventionmentioning

confidence: 99%

Prevention of Oxidative Stress Injury to Sperm

Agarwal

Prabakaran

Said

2005

Journal of Andrology

244

132

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“…A recent prospective randomized study using a direct evaluation of sperm DNA fragmentation by TUNEL assay (Greco et al, 2005b) has confirmed these findings. However, some reports questioned the usefulness of antioxidants in the treatment of male infertility (Martin-Du Pan and Sakkas, 1998;Bolle et al, 2002;Agarwal et al, 2004), and in-vitro effects of antioxidants on sperm DNA integrity are inconsistent (Hughes et al, 1998;Donnelly et al, 1999). To our knowledge, no evaluation of the effect of oral antioxidant treatment on ICSI clinical outcomes in cases with elevated sperm DNA damage has yet been reported.…”

Section: Introductionmentioning

confidence: 99%

ICSI in cases of sperm DNA damage: beneficial effect of oral antioxidant treatment

Greco

Romano²,

Iacobelli³

et al. 2005

Human Reproduction

229

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“…Numerous clinical trials have investigated the potential role of antioxidant therapy to relieve ROS-induced male factor infertility [23]. Although antioxidants are hypothesized to be useful therapeutic agents for male infertility, the results of clinical trials are controversial [23,24]. In this study, we investigated the patterns of antioxidant use among infertile male patients in Jordan.…”

Section: Discussionmentioning

confidence: 99%

Alternative and antioxidant therapies used by a sample of infertile males in Jordan: a cross-sectional survey

Bardaweel

2014

BMC Complement Altern Med

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BackgroundComplementary and alternative medicine (CAM) is frequently used in the Middle East, especially to treat chronic diseases such as infertility. We aimed to examine the prevalence, characteristics, and determinants of CAM use, particularly herbs and antioxidant therapies, among infertile males presenting for infertility evaluation in Jordan.MethodsDemographic information, use of alternative and antioxidant therapies for infertility treatment, and patients’ belief in efficacy and safety of the therapies used were collected using a face-to-face questionnaire. Data were collected from 428 infertile male patients presenting at infertility clinics in Amman, the capital city of Jordan. The study was conducted between April 2013 and September 2013.ResultsOf the 428 men who completed the questionnaire, 184 (43%) used at least one of the alternative and antioxidant therapies specified in the questionnaire. Nutritional regime; vitamins, such as vitamins C and E; and medicinal herbs, such as ginger, saw palmetto, and ginseng were the most commonly used therapies reported. A correlation between the use of alternative and antioxidant therapies versus infertility duration was found. Additionally, the majority of males using CAM did not inform their health care providers about their usage.ConclusionsThe high prevalence of CAM use among infertile male patients underscores the urge to assimilate CAM into the education and training of health professionals, as well as to improve infertile patients’ knowledge of the safe use of CAM modalities.

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Is antioxidant therapy a promising strategy to improve human reproduction? Are anti-oxidants useful in the treatment of male infertility?

Cited by 20 publications

References 24 publications

Prevention of Oxidative Stress Injury to Sperm

Prevention of Oxidative Stress Injury to Sperm

ICSI in cases of sperm DNA damage: beneficial effect of oral antioxidant treatment

Alternative and antioxidant therapies used by a sample of infertile males in Jordan: a cross-sectional survey

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