Is antimicrobial administration to food animals a direct threat to human health? A rapid systematic review

Scott, Anna Mae; Beller, Elaine; Glasziou, Paul; Clark, Justin; Ranakusuma, Respati W.; Byambasuren, Oyungerel; Bakhit, Mina; Page, Stephen W.; Trott, Darren J.; Mar, Chris Del

doi:10.1016/j.ijantimicag.2018.04.005

Cited by 102 publications

(78 citation statements)

References 25 publications

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“…This prospect has motivated calls for increased antimicrobial stewardship in agriculture, including the reduction and elimination of antimicrobials as growth promoters and unnecessary prophylaxis. In theory, these changes should reduce the magnitude of antibiotic use, leading to a reduction in the abundance of antimicrobial-resistant bacteria and related transfer of resistance traits to zoonotic pathogens, and a reduction in transmission of antimicrobial-resistant bacteria through the food chain and environment [2][3][4][5][6][7][8][9] .…”

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confidence: 99%

Antimicrobial resistant enteric bacteria are widely distributed amongst people, animals and the environment in Tanzania

et al. 2020

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Antibiotic use and bacterial transmission are responsible for the emergence, spread and persistence of antimicrobial-resistant (AR) bacteria, but their relative contribution likely differs across varying socio-economic, cultural, and ecological contexts. To better understand this interaction in a multi-cultural and resource-limited context, we examine the distribution of antimicrobial-resistant enteric bacteria from three ethnic groups in Tanzania. Householdlevel data (n = 425) was collected and bacteria isolated from people, livestock, dogs, wildlife and water sources (n = 62,376 isolates). The relative prevalence of different resistance phenotypes is similar across all sources. Multi-locus tandem repeat analysis (n = 719) and whole-genome sequencing (n = 816) of Escherichia coli demonstrate no evidence for hostpopulation subdivision. Multivariate models show no evidence that veterinary antibiotic use increased the odds of detecting AR bacteria, whereas there is a strong association with livelihood factors related to bacterial transmission, demonstrating that to be effective, interventions need to accommodate different cultural practices and resource limitations.

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confidence: 99%

Antimicrobial resistant enteric bacteria are widely distributed amongst people, animals and the environment in Tanzania

et al. 2020

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“…the transmission of NDM-5 ST167 Escherichia coli, CTX-M-9 ST69 E. coli and multidrug-resistant Pseudomonas aeruginosa (MDRPA) at the human-dog-environment interface (Fernandes et al 2018; Gr€ onthal et al 2018). In addition, many antimicrobial agents, used for veterinary purposes to treat a wide range of microbial infections across many animal species, are within the same class as human therapeutic drugs, potentially increasing AMR in humans (Wijesekara et al 2017;Scott et al 2018).…”

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confidence: 99%

Antimicrobial effects of cinnamon essential oil and cinnamaldehyde combined with EDTA against canine otitis externa pathogens

Sim

Khazandi

et al. 2019

J Appl Microbiol

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Aims The antimicrobial activity of cinnamon essential oil and cinnamaldehyde against bacterial and fungal pathogens associated with canine otitis externa, as well as the effect of their combination with EDTA were investigated. Methods and Results Antimicrobial susceptibility testing was performed using the broth microdilution method while spot‐plating technique was used to determine their bactericidal activity. Time‐kill kinetics and checkerboard assays were performed to confirm the bactericidal activity and combination effects of the compounds. Cinnamon oil and cinnamaldehyde exhibited antimicrobial activity against Gram‐positive and Gram‐negative pathogens, as well as Malassezia pachydermatis. Synergistic interaction was shown when EDTA (672 μg ml−1) was combined with cinnamon oil (41 μg ml−1) and cinnamaldehyde (22 μg ml−1) against Pseudomonas aeruginosa. Cinnamaldehyde exhibited significantly stronger antimicrobial activity than cinnamon bark oil. Conclusions Cinnamon essential oil and cinnamaldehyde, either used alone or in combination with EDTA, were effective against the causative micro‐organisms of canine otitis externa. The data suggest that cinnamaldehyde could be a promising antimicrobial agent against canine otitis externa. Significance and Impact of the Study This study shows that cinnamon essential oil and cinnamaldehyde, especially the latter, could be used in combination with EDTA as novel treatment for sensitive and resistant bacterial and fungal pathogens involved in canine otitis externa.

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“…They also observed a similar correlation between reduced antibiotic use in food-animals and reduced prevalence of antibiotic resistance in humans, specifically in humans that had a direct contact with food-producing animals. A similar study carried out by Scott et al [55], where the authors analyzed 93 studies using different animal species, antimicrobial classes, interventions, administration routes, samples and methods, showed that limiting antimicrobial use in food-animals subsequently reduces antimicrobial resistance in food-animals. These two systematic reviews, analyzing the large body of literature, undoubtedly showed that interventions designed to reduce use of antibiotics in food-producing animals indeed have a positive effect on reducing the prevalence of antibiotic resistance in both animals and humans that are in contact with food-producing animals.…”

Section: Antimicrobial Resistance Associated With Food Producing Animalsmentioning

confidence: 85%

Antimicrobial Resistance and Food Animals: Influence of Livestock Environment on the Emergence and Dissemination of Antimicrobial Resistance

Vidovic

Vidović

2020

Antibiotics

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The emergence and dissemination of antimicrobial resistance among human, animal and zoonotic pathogens pose an enormous threat to human health worldwide. The use of antibiotics in human and veterinary medicine, and especially the use of large quantities of antibiotics in livestock for the purpose of growth promotion of food animals is believed to be contributing to the modern trend of the emergence and spread of bacteria with antibiotic resistant traits. To better control the emergence and spread of antimicrobial resistance several countries from Western Europe implemented a ban for antibiotic use in livestock, specifically the use of antibiotics for growth promotion of food animals. This review article summarizes the recent knowledge of molecular acquisition of antimicrobial resistance and the effects of implementation of antibiotic growth promoter bans on the spread of antimicrobial resistant bacteria in animals and humans. In this article, we also discuss the main zoonotic transmission routes of antimicrobial resistance and novel approaches designed to prevent or slow down the emergence and spread of antimicrobial resistance worldwide. Finally, we provide future perspectives associated with the control and management of the emergence and spread of antimicrobial resistant bacteria.

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Is antimicrobial administration to food animals a direct threat to human health? A rapid systematic review

Abstract: Limiting antimicrobial use in food animals reduces antimicrobial resistance in food animals, and probably reduces antimicrobial resistance in humans. The magnitude of the effect cannot be quantified.

Cited by 102 publications

References 25 publications

Antimicrobial resistant enteric bacteria are widely distributed amongst people, animals and the environment in Tanzania

Antimicrobial resistant enteric bacteria are widely distributed amongst people, animals and the environment in Tanzania

Antimicrobial effects of cinnamon essential oil and cinnamaldehyde combined with EDTA against canine otitis externa pathogens

Antimicrobial Resistance and Food Animals: Influence of Livestock Environment on the Emergence and Dissemination of Antimicrobial Resistance

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