Is aneuploidy screening for patients aged 35 or over beneficial? A prospective randomized trial

Selecting a Single Embryo for Transfer after In-vitro Fertilization: A Translational Medicine Perspective

“…Contrary to expectation, results from numerous studies did not show that the PGS-FISH was capable of improving live birth rates in patients of advanced maternal age, with recurrent implantation failure or repeated pregnancy loss [35][36][37][38][39][40][41][42][43][44][45][46]. This is because FISH screening does not make it possible to test for all 23 chromosome pairs.…”

IVF/ICSI with or without preimplantation genetic screening for aneuploidy in couples without genetic disorders: a systematic review and meta-analysis

“…Ten prospective, randomized, parallel-group, controlled studies evaluating PGS for aneuploidies in IVF/ICSI versus IVF/ICSI met the inclusion criteria [10][11][12][13][14][25][26][27][28][29][30].…”

“…One of the trials was published as an abstract and included only 39 patients [13] and in the other trial, an intention to treat analysis was not performed [14]. Because of these limitations and given that further data have been published in the literature, a systematic review and meta-analysis was conducted to assess the effectiveness of PGS as a tool to increase ongoing pregnancy rates in cases of advanced maternal age, repeated IVF failure, repeated pregnancy loss (poor prognosis) but also in the general IVF population in couples without known genetic disorders but doubling the sample size of the previous review [12].…”

Comment on Checa MA et al. J Assist Reprod Genet DOI 10.1007/s10815-009-9328-4

“…It appears that the study of Schoolcraft et al [4] is a full paper version of the abstract by Stevens et al [5], although I could not find any mention of the abstract by Stevens et al [5] in the full paper. The investigators were from the same institution and the studies were carried out during the same period: from May 2002 to March 2004.…”

“…Although the deletion of the abstract by Stevens et al [5] in the meta-analysis is unlikely to change the overall results, it is still important to follow the basic principles of the meta-analysis.…”