Is anemia frequent in HIV/AIDS patients presenting to a tertiary care hospital?

Butt, Nauman Ismat; Tehseen, Nouman; Malik, Tashia; Kakar, Aniqa Anser Tufail Khan; Ashfaq, Fahmina; Nouman, Ayesha

doi:10.47391/jpma.321

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…This level of anaemia was in accordance with published ndings from the USA (30.3%) [23], Wolaita Sodo (36.5%) [15], Debre tabor (34%) [17], systematic review and meta-analysis in Ethiopia (31%) [24], Hawassa (29.9%) [25], China (39.2%) [26], and Mekele (33.5%) [27]. However, this rate is lower than that found in Jimma (51.5%) [12], Nepal (66.7%) [28], Pakistan (66.1%) [29], and Spain at (41.5%) [30]. Similarly this nding is lower than ndings (66%) from a longitudinal study evaluating HIV-infected patients who initiate the 1j regimen for six months [31].…”

Section: Discussionmentioning

confidence: 99%

Unveiling the Prevalence of Anaemia and Its Predictors Among Adults on Highly Active Antiretroviral Therapy in the Dolutegravir Era: a Retrospective Cross-sectional Study

Zewdu,

Zeleke,

Ferede

et al. 2024

Preprint

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Introduction Both HIV/AIDS and anaemia are the most pressing public health issues globally. Moreover, there is a dearth of evidence regarding the frequency, severity, and prevalence of anaemia among HIV/AIDS-positive patients receiving antiretroviral therapy in Ethiopia following the rollout of the dolutegravir-based regimen by 2019 as the preferred first-line regimen. Thus, this study is aimed at assessing the prevalence, severity, and associated factors of anaemia among adult HIV-positive ART-experienced patients in Woreta Primary Hospital (WPH). Methods A health institution-based retrospective cross-sectional study design was conducted to evaluate the prevalence and factors influencing anaemia in HIV/AIDS-positive patients from February 2019 to September 2023. Medical record abstraction tools were used to gather data. Employing initially bivariate and then multivariate logistic regression models, the data were evaluated to uncover factors linked with anaemia. The Hosmer-Lemeshow goodness-of-fit test was applied to investigate the model's validity. Results The total prevalence of anaemia was 31.5% [95% CI: 28.9–33.8]. The prevalence of mild, moderate, and severe anaemia was 20.42%, 10.38%, and 0.70%, respectively. Predictors independently linked with anaemia were: female sex (AOR: 1.08), age ≥40 years (AOR: 1.21), lived with HIV >10 years (AOR: 2.31), CD4 counts <200 cells/μL (AOR: 3.81), nonsuppressed viral load (AOR: 1.28), history of opportunistic infections (AOR: 1.54), WHO clinical stage III & IV (AOR: 1.37, & 2.23, respectively), and history of parasitic infestation (AOR: 2.81). Conclusions A sizeable proportion of subjects were found anaemic. Female sex, older age, longer periods lived with the virus, lower CD4 count, nonsuppressed viral load, history of opportunistic infections, WHO clinical stages III and IV, and history of parasitic infestation were the contributing factors. Therefore, to improve the anaemic status and living circumstances of HIV-positive patients, immediate action on the linked variable is needed.

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Section: Discussionmentioning

confidence: 99%

Unveiling the Prevalence of Anaemia and Its Predictors Among Adults on Highly Active Antiretroviral Therapy in the Dolutegravir Era: a Retrospective Cross-sectional Study

Zewdu,

Zeleke,

Ferede

et al. 2024

Preprint

View full text Add to dashboard Cite

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Prevalence of anemia among people living with HIV: A systematic review and meta-analysis

Cao

Wang

et al. 2022

eClinicalMedicine

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Background Anemia is the most frequent hematologic abnormality among people living with human immunodeficiency virus (HIV) (PLWHIV) and is associated with HIV disease progression and higher risk of mortality of the patients. However, there is a wide variation of the prevalence of anemia among PLWHIV in different clinical settings. We aimed to obtain more precise estimates of prevalence of anemia and severity of anemia among PLWHIV, which may be important for patients, caregivers, researchers and health policy-makers.Methods We systematically searched PubMed, EMBASE, Web of Science, and Cochrane Library for original articles reporting the prevalence of anemia defined using age and sex-specific hemoglobin levels according to World Health Organization criteria among PLWHIV from inception to August 31, 2021. We used DerSimonian-Laird randomeffects meta-analyses to obtain pooled prevalence and 95% confidence intervals (CIs) of anemia and severity of anemia among PLWHIV. A univariable meta-regression has been conducted to assess the association between anemia prevalence and study characteristics, including study design, median year of sampling, geographical region, World Bank Income level, and proportion of antiretroviral therapy (ART). FindingsWe included 63 observational studies covering 110,113 PLWHIV. The pooled prevalence of anemia was 39.7% (95% CI: 31.4%-48.0%) for children living with HIV aged <15 years, 46.6% (95% CI: 41.9%-51.4%) for adults (men and non-pregnant women) living with HIV aged ≥15 years, and 48.6% (95% CI: 41.6%-55.6%) for pregnant women living with HIV. Among adults living with HIV, the pooled prevalence of severity of anemia was 21.6% (95% CI: 19.9%-23.3%), 22.6% (95% CI: 14.8%-30.4%), and 6.2% (95% CI: 4.4%-8.1%) for mild, moderate and severe anemia, respectively. Compared with East Africa, anemia prevalence among adults living with HIV was higher in Southern Africa (p = 0.033).Interpretation Anemia is prevalent among PLWHIV. Thus, policies, strategies, and programs should be considered to identify the predictors of anemia among PLWHIV to reduce the burden of anemia among patients in the ART era.

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Is anemia frequent in HIV/AIDS patients presenting to a tertiary care hospital?

Cited by 2 publications

References 8 publications

Unveiling the Prevalence of Anaemia and Its Predictors Among Adults on Highly Active Antiretroviral Therapy in the Dolutegravir Era: a Retrospective Cross-sectional Study

Unveiling the Prevalence of Anaemia and Its Predictors Among Adults on Highly Active Antiretroviral Therapy in the Dolutegravir Era: a Retrospective Cross-sectional Study

Prevalence of anemia among people living with HIV: A systematic review and meta-analysis

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