Is anemia a new cardiovascular risk factor?

Kaiafa, Georgia; Kanellos, Ilias; Savopoulos, Christos; Kakaletsis, Nikolaos; Giannakoulas, George; Hatzitolios, Apostolos

doi:10.1016/j.ijcard.2015.03.159

Cited by 69 publications

(48 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results extend and are largely consistent with earlier observations documenting a high prevalence of anemia in both heart failure and ACS 4. Others have also shown excess risk associated with anemia in the setting of ACS 5, 6, 7.…”

Section: Introductionsupporting

confidence: 91%

Anemia and Acute Coronary Syndrome: Time for Intervention Studies

Farhan

Baber

Mehran

2016

JAHA

View full text Add to dashboard Cite

Section: Introductionsupporting

confidence: 91%

Anemia and Acute Coronary Syndrome: Time for Intervention Studies

Farhan

Baber

Mehran

2016

JAHA

View full text Add to dashboard Cite

“…In addition, NO has been proposed as a critical regulator of cell deformability (22, 93, 181), although some controversy in the literature exists about these effects (15). Administration of NOS inhibitors decreased RBC deformability as assessed by ektacytometry (22), while low concentrations of NO donors increase RBC deformability (22), membrane fluidity (181), and RBC filterability (99).…”

Section: Rbc Mechanical Properties and Blood Rheologymentioning

confidence: 99%

“…These changes are mainly due to increased preload, decreased afterload, and changes in cardiac geometry so that left ventricular systolic dysfunction may develop over time in patients without CVD. In addition, a pre-existing heart failure may be aggravated due to chronic anemia (7, 93). It was proposed that an increased sympathetic activity and an altered stimulation of the renin–angiotensin–aldosterone system may also contribute to the hyperdynamic state in anemia.…”

Section: Rbc Dysfunction and Anemiamentioning

confidence: 99%

Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia

Kuhn

Diederich

Keller

et al. 2017

Antioxidants & Redox Signaling

334

250

View full text Add to dashboard Cite

Significance: Recent clinical evidence identified anemia to be correlated with severe complications of cardiovascular disease (CVD) such as bleeding, thromboembolic events, stroke, hypertension, arrhythmias, and inflammation, particularly in elderly patients. The underlying mechanisms of these complications are largely unidentified.Recent Advances: Previously, red blood cells (RBCs) were considered exclusively as transporters of oxygen and nutrients to the tissues. More recent experimental evidence indicates that RBCs are important interorgan communication systems with additional functions, including participation in control of systemic nitric oxide metabolism, redox regulation, blood rheology, and viscosity. In this article, we aim to revise and discuss the potential impact of these noncanonical functions of RBCs and their dysfunction in the cardiovascular system and in anemia.Critical Issues: The mechanistic links between changes of RBC functional properties and cardiovascular complications related to anemia have not been untangled so far.Future Directions: To allow a better understanding of the complications associated with anemia in CVD, basic and translational science studies should be focused on identifying the role of noncanonical functions of RBCs in the cardiovascular system and on defining intrinsic and/or systemic dysfunction of RBCs in anemia and its relationship to CVD both in animal models and clinical settings. Antioxid. Redox Signal. 26, 718–742.

show abstract

“…Although haemoglobin levels are generally only moderately reduced in anaemia of chronic disease, the decreased oxygen delivery associated with this condition is sufficient to exacerbate symptoms in patients with cardiovascular comorbidities. 185 Treatment in these individuals is directed towards alleviating symptoms such as angina, fatigue, or functional limitation.…”

Section: H1 Bmps and The Cardiovascular Systemmentioning

confidence: 99%

Targeting BMP signalling in cardiovascular disease and anaemia

et al. 2015

View full text Add to dashboard Cite

Bone morphogenetic proteins (BMPs) and their receptors, known to be essential regulators of embryonal patterning and organogenesis, are also critical for the regulation of cardiovascular structure and function. In addition to their contributions to syndromic disorders of heart and vascular development, BMP signalling is increasingly recognized for its influence on endocrine-like functions in postnatal cardiovascular and metabolic homeostasis. In this Review, we discuss several critical and novel aspects of BMP signalling in cardiovascular health and disease, which highlight the cell- and context-specific nature of BMP signalling. Based on advancing knowledge of the physiological roles and regulation of BMP signaling, we indicate opportunities for therapeutic intervention in a range of cardiovascular conditions including atherosclerosis and pulmonary arterial hypertension, and well as for anaemia of chronic disease. Depending on the context and the repertoire of ligands and receptors involved in specific disease processes, the selective inhibition or enhancement of signaling via particular BMP ligands (such as in atherosclerosis and pulmonary arterial hypertension, respectively) might be beneficial. The development of selective small molecule antagonists of BMP receptors, and the identification of ligands selective for BMP receptor complexes expressed in the vasculature provide the most immediate opportunities for new therapies.

show abstract

Is anemia a new cardiovascular risk factor?

Cited by 69 publications

References 71 publications

Anemia and Acute Coronary Syndrome: Time for Intervention Studies

Anemia and Acute Coronary Syndrome: Time for Intervention Studies

Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia

Targeting BMP signalling in cardiovascular disease and anaemia

Contact Info

Product

Resources

About