Is amoxicillin-cotrimoxazole the most appropriate antibiotic regimen for listeria meningoencephalitis? Review of 22 cases and the literature

Merle-Melet, M.; Dossou-Gbete, L.; Maurer, Patrick; Meyer, P.; Lozniewski, Alain; Kuntzburger, O.; Weber, Michèle; Gérard, Alain

doi:10.1016/s0163-4453(96)92929-1

Cited by 68 publications

(22 citation statements)

References 33 publications

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“…In a study of Merle-Melet et al the combination of cotrimoxazole plus ampicillin was associated with lower failure rate and fewer neurologic sequelae than ampicillin with gentamicin. The same study found out failure of ampicillin and gentamicin in 57% of patients [20]. In majority of our patients, we observed a favorable response to the combination of ampicillin plus gentamicin.…”

Section: Discussionsupporting

confidence: 76%

Listeria monocytogenesMeningitis in Adults: The Czech Republic Experience

Džupová

Rozsypal²,

Smíšková³

et al. 2013

BioMed Research International

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Background. Listeria monocytogenes (LM) is currently the third most frequent pathogen of bacterial meningitis in adults. Methods. A prospective study of patients with LM meningitis in a Czech tertiary care hospital, carried out from 1997 to 2012. Results. Thirty-one patients were diagnosed with LM meningitis, which was 7% of a total of 440 adult patients with acute bacterial meningitis (ABM) over a 16-year period. Their median age was 63 years, range 26–80 years. Nineteen patients (61%) had underlying immunocompromising comorbidity; 15 patients (48%) were older than 65 years. Fourteen patients (45%) had arterial hypertension. The typical triad of fever, neck stiffness, and altered mental status was present in 21 patients (68%). The median count of cerebrospinal fluid (CSF) leukocytes was 680/μL, protein level 2.6 g/L, and glucose ratio 0.28. Four patients (13%) died, and nine (29%) survived with moderate to severe sequelae. Conclusion. LM meningitis is known to affect immunosuppressed and elderly patients. Arterial hypertension seems to be another important predisposing factor. Clinical symptoms, CSF findings, and disease outcomes, did not significantly differ from other community-acquired ABM in our study, although the CSF leukocyte count was lower. Ampicillin showed good clinical and bacteriological efficacy in the majority of patients.

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Section: Discussionsupporting

confidence: 76%

Listeria monocytogenesMeningitis in Adults: The Czech Republic Experience

Džupová

Rozsypal²,

Smíšková³

et al. 2013

BioMed Research International

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“…Besides clinical descriptions, few data are available on Lm -associated meningoencephalitis. CT scan resolution has proven so far to be insufficiently precise to gain insight into the neuropathology of Lm -associated encephalitis, and magnetic resonance imaging (MRI) allows visualization of diffuse but so far rather unspecific lesions 40 , 41 …”

Section: Natural History Of Neurolisteriosismentioning

confidence: 99%

Targeting of the central nervous system byListeria monocytogenes

2012

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Among bacteria that reach the central nervous system (CNS), Listeria monocytogenes (Lm) is one of deadliest, in human and ruminant. This facultative intracellular bacterium has the particularity to induce meningitis, meningoencephalitis and rhombencephalitis. Mechanisms by which Lm accesses the CNS remain poorly understood, but two major routes of infection have been proposed, based on clinical, in vitro and in vivo observations. A retrograde neural route is likely to occur in ruminants upon crossing of the oral epithelium, and this probably accounts for the observation that Lm induces almost exclusively rhombencephalitis in these animals. In contrast, the hematogenous route is likely the most frequent in human, in whom bacteria circulating in the blood, either free or associated with leukocytes are thought to breach the blood-brain barrier. New animal models that faithfully reproduce the hallmarks of human neurolisterisosis will allow addressing the molecular mechanisms underlying Lm ability to induce CNS disease, and improve our understanding of the pathophysiology of this deadly infection.

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“…She received chemotherapy containing a high dose of glucocorticoid. Her positive blood cultures confirmed the diagnosis and the percentage of positive blood cultures is 59–73% [17,18]. Our patient had obvious symptoms of central nervous system involvement, but the definite diagnosis of meningitis could not be ascertained because her relatives refused further examination, including brain CT and CSF examination.…”

Section: Discussionmentioning

confidence: 58%

Listeria septicemia accompanied by central nervous system involvement in a patient with multiple myeloma and secondary diabetes

Yao

et al. 2013

Am J Case Rep

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Patient: Female, 58Final Diagnosis: Listeria septicemiaSymptoms: Nausea • vomitting • high fever • apathetic intelligence • repeated convulsionMedication: LevofloxacinClinical Procedure: —Specialty: HematologyObjective: Rare diseaseBackground:Multiple myeloma is a hematological malignancy that frequently causes secondary diabetes due to chemotherapy using hormones and infection due to immunosuppression.Case Reports:The patient was a 58-year-old woman with multiple myeloma and secondary diabetes complicated by listeria septicemia accompanied by central nervous system involvement. She initially received moxalactam and etimicin sulfate, but blood cultures detected Listeria monocytogenes. Levofloxacin was administered, but the symptoms did not improve. The patient ultimately died.Conclusions:Listeria septicemia accompanied by central nervous system involvement in a patient with multiple myeloma and secondary diabetes is a relatively rare disease. Prevention, timely diagnosis, and treatment are the key steps for improvement. Blood glucose level control is another important factor that should be considered in the prevention and treatment for Listeria monocytogenes infection.

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Is amoxicillin-cotrimoxazole the most appropriate antibiotic regimen for listeria meningoencephalitis? Review of 22 cases and the literature

Cited by 68 publications

References 33 publications

Listeria monocytogenesMeningitis in Adults: The Czech Republic Experience

Listeria monocytogenesMeningitis in Adults: The Czech Republic Experience

Targeting of the central nervous system byListeria monocytogenes

Listeria septicemia accompanied by central nervous system involvement in a patient with multiple myeloma and secondary diabetes

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