Is Allergic Sensitization to Siberian Hamster Preventable in High-Risk Individuals Who Are Already Sensitized or Exposed to Furry Animals?

Liccardi, Gennaro; Salzillo, Antonello; Calzetta, Luigino; Piccolo, Amedeo; Puxeddu, Ermanno; Rogliani, Paola

doi:10.18176/jiaci.0100

Cited by 3 publications

(4 citation statements)

References 6 publications

(9 reference statements)

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“…It is common for individuals to become sensitized to both pets at the same time. Individuals who are allergic to one pet are 14 times more likely to be allergic to other pets, with approximately 75% showing cross-sensitization [19]. The homology and/or structural similarity between canine and feline allergens, such as albumins and lipocalins, explain the cross-reactivity between them and other mammals [20].…”

Section: Discussionmentioning

confidence: 99%

Increasing Prevalence of Sensitization to Cat/Dog Allergens in the COVID-19 Pandemic

Evcen,

Çölkesen,

Yıldız

et al. 2023

Int Arch Allergy Immunol

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Introduction: Cat and dog allergens are common indoor triggers for respiratory allergies such as allergic rhinitis and asthma. This study aims to evaluate the prevalence of cat and dog allergies in adults and analyze changes during the COVID-19 pandemic. Methods: We retrospectively analyzed the medical records of 8,102 patients who visited an allergy clinic and underwent skin prick testing (SPT) from March 2018 to March 2022: 2 years before and 2 years during the pandemic. Demographic information, clinical attributes, and laboratory results were examined based on patient records. Results: Of 8,102 SPTs performed, 400 (4.9%) were sensitized to cat allergen and 289 (3.6%) to dog allergen. Allergic rhinitis was the predominant clinical diagnosis in both groups. Of the 400 subjects exposed to cats, 240 (60%) experienced allergic symptoms, while of the 289 subjects exposed to dogs, 65 (22.5%) experienced allergic symptoms during exposure. Within the cat-sensitized group, anaphylaxis was observed in 5 patients (1.3%), while no cases of anaphylaxis were reported in the dog-sensitized group. Compared to the pre-pandemic period, patients presenting during the pandemic had higher rates of cat and dog sensitization (5.7% vs. 4.1%; p < 0.05, 5.2% vs. 1.7%; p < 0.05). Conclusion: During the COVID-19 pandemic, there was an increase in cat and dog allergies among adults. Increased exposure to pet antigens, both directly and indirectly, has resulted in more people becoming sensitized to cats or dogs.

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Section: Discussionmentioning

confidence: 99%

Increasing Prevalence of Sensitization to Cat/Dog Allergens in the COVID-19 Pandemic

Evcen,

Çölkesen,

Yıldız

et al. 2023

Int Arch Allergy Immunol

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“…This is because studies on adult patients with allergy to dwarf hamsters have shown the occurrence of allergic reactions 1-2 months after exposure. 16,18 In addition, unlike dog and cat antigens, the major allergenic components of hamsters have not been identified and are not commercially available. Thus, we inevitably used a crude extract of hamsters.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, six protein bands were identified in the in-house processed Syrian hamster extract, including three additional bands not found in the standard commercial preparation. When six adult patients were diagnosed with dwarf (Siberian) hamster allergy, they tested negative in the skin prick test preparation, but IgE responses to proteins (18,21, and 32 kDa) in the hamster hair and saliva samples were identified. 9,11 As shown in the present study, differences in allergenic potency and composition may be owing to a number of factors, including the difference in sampling sites used to obtain the crude extracts.…”

Section: Discussionmentioning

confidence: 99%

Cross-reactivity of Can f 1 with Syrian hamster and Fel d 1 in children

Lee

Jeon

Lee

2021

aei

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Introduction and objectives: With increasing pet allergies among pediatric patients, the need for precise environmental care is increasing. We investigated the clinical, immunological, and environmental characteristics of pediatric patients sensitized to a dog to evaluate the cross-antigenicity of canine lipocalin Can f 1 with feline lipocalin Fel d 1 and Syrian hamsterextract.Materials and methods: The protein fractions of the processed and commercial Syrian hamster extracts were compared using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). An enzyme-linked immunosorbent assay (ELISA) inhibition test was performed on Can f 1, Fel d 1, and processed Syrian hamster extract, and the antigen-specific immunoglobulin E (IgE)-binding capacity for each antigen was analyzed using serum samples from patients.Results: Twelve of 19 patients with a median age of 40.5 months were symptomatic when exposed to dogs. Eleven (91.7%) patients showed a positive IgE response to Can f 1. Two patients were positive for Fel d 1-specific IgE antibody, and one was positive for hamster-specific IgE antibody. SDS-PAGE confirmed the presence of different patterns of protein bandsbetween the commercial and processed hamster extracts. There was no cross-antigenicity among Can f 1, Fel d 1, and processed Syrian hamster extract.Conclusions: Since the standard commercial hamster extract did not contain Syrian hamster antigens that were diverse enough, caution should be taken when using it. In children allergic to cats and dogs, sensitization to isolated Can f 1 or Fel d 1 is unlikely to cause cross-reactivity to Syrian hamster hair and epithelium.

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“…In addition, an increased risk of sensitization to other animal allergens, especially to dogs, has been reported in cat-sensitized patients [ 5 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

The importance of skin prick test in differentiating cat sensitivities and allergies in children

KAYA,

ATAY,

HACI

et al. 2023

Turkish Journal of Medical Sciences

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Background/aim The incidence of cat allergies in children has increased over the years. Children with cat allergies have mostly reported respiratory symptoms. The skin prick test (SPT) is the most preferred method to demonstrate sensitization to allergens. However, not all children who develop cat sensitization due to environmental exposure become allergic to cats. In our study, we aimed to determine the frequency of sensitization to cat and cat allergy, cat-related symptoms, and the cut-off value for the SPT that may indicate cat allergy. Materials and methods Patients aged 2–18 years, who applied to the Health Sciences University İzmir Dr Behçet Uz Pediatrics and Surgery Training and Research Hospital and Balıkesir University Application and Research Hospital Pediatric Allergy outpatient clinics between January 01, 2019 and December 31, 2020, were included in the study. Patients who underwent SPT and found to be sensitized to cat allergen, were evaluated retrospectively. Clinical and laboratory findings of the patients were recorded. Receiver operating characteristics (ROC) analysis was performed to determine the cut-off value for the SPT. Results Sensitization to cat was detected in 140 (4%) out of 3499 patients who underwent SPT. The median age of the patients was 12 years (min–max: 5–18) and 67.1% were male. Eighty-eight (62.9%) patients were symptomatic upon contact with cats, predominantly with nasal symptoms. These patients had significantly larger cat SPT wheal size than asymptomatic patients. The cut-off value was determined as 5.5 mm with a sensitivity of 72.7% and a specificity of 61.5% (95% CI, 60.5%–78.4%). Symptoms resolved in about half of our patients by reducing contact with cats. Conclusion The present study is the first to report the frequency and clinical findings of cat sensitizations and allergies in Turkish children. For effective treatment, cat allergy must be diagnosed. In this regard, the use of a practical, readily accessible 5.5 mm cut-off point on the SPT may be helpful.

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Is Allergic Sensitization to Siberian Hamster Preventable in High-Risk Individuals Who Are Already Sensitized or Exposed to Furry Animals?

Cited by 3 publications

References 6 publications

Increasing Prevalence of Sensitization to Cat/Dog Allergens in the COVID-19 Pandemic

Increasing Prevalence of Sensitization to Cat/Dog Allergens in the COVID-19 Pandemic

Cross-reactivity of Can f 1 with Syrian hamster and Fel d 1 in children

The importance of skin prick test in differentiating cat sensitivities and allergies in children

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