Is Alerting Response Related to Cardiovascular Comorbities?: PP.14.32

Hypertension in the first blood pressure reading and the risk of cardiovascular disease mortality in the general population: findings from the prospective KORA study

“…Cross-sectionally, an alerting reaction was associated with an adverse sociodemographic, lifestyle and somatic risk factor profile at baseline, including increasing age, male gender, lower education levels, physical inactivity, increased alcohol consumption, obesity, hypercholesterolemia, and history of CVD in comparison to participants with normotension. Previous findings have shown conflicting results of the association between an alerting response and CVD risk factors, with evidence for [15], and opposing a worsened risk factor profile [17], including CVD comorbidities and target organ damage. However, in the opposing evidence, the first BP reading was compared to ambulatory blood pressure measurements in 163 participants, which is not directly comparable to the current methodology.…”

“…Previous studies have shown evidence of a link between an alerting reaction and target organ damage, as well as future adverse CVD events [15,16]. However, a toxic effect of an alerting reaction was not replicated in an additional ambulatory study investigating the link between the alerting reaction, target organ damage and CVD comorbidities [17]. Given the utmost importance of accurate BP measurement and the contradictory state of the art, the present investigation used population-based data from the prospective KORA study to investigate the clinical characteristics and consequences of an alerting reaction reading that should meet hypertension criteria yet followed by a decrease to normotension in the following 2 readings, hence considered as normotension.…”