Is age at menopause increasing across Europe? Results on age at menopause and determinants from two population-based studies

Dratva, Julia; Real, Francisco Gómez; Schindler, Christian; Ackermann‐Liebrich, Ursula; Gerbase, Margaret W.; Probst‐Hensch, Nicole; Svanes, Cecilie; Omenaas, Ernst; Neukirch, Françoise; Wjst, Matthias; Morabia, Alfredo; Jarvis, Déborah; Leynaert, Bénédicte; Zemp, Elisabeth

doi:10.1097/gme.0b013e31818aefef

Cited by 207 publications

(164 citation statements)

References 41 publications

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“…This estimation of the age at menopause in Hungary fits this European interval and the former meta-analysis estimation of age at menopause for the European region (50.79 years) [87].…”

Section: Discussionsupporting

confidence: 81%

Body fatness and endogenous sex hormones in the menopausal transition

et al. 2016

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a b s t r a c tBackground: Age at the final menstrual period is of clinical and public health interest because the age at which natural menopause occurs may be a marker of ageing and health, and in general the menopausal transition increases the risk of many diseases, e.g. redistribution in the pattern of adiposity during the menopausal transition may increase risk of metabolic disease. The purpose of this research was to study the relationship between the menopausal status and body fatness. Subjects and methods: A random sample of 1932Hungarian women was studied. Body composition was estimated by body impedance analysis. In a subsample free estradiol and progesterone levels in saliva were quantified. Results: Body fat mass increased until the late 50s and then had a decrease through senescence. Premenopausal women who were much older than the median age at menopause had a higher amount of fat than their postmenopausal age-peers, while postmenopausal women, whose menopause occurred much earlier than the median age at menopause, had less fat than their premenopausal age-peers. The body fat mass in premenopausal women with low levels of sex hormones was always below the agemedian value of the menopausal status subgroups, while the body fat mass of postmenopausal women with high levels of sex hormone levels was above the age-median values. Conclusions: The analysis of body fatness in the menopausal transition revealed that (1) the rate of reproductive ageing and the body fat pattern were significantly related, and (2) body fat mass of women with unexpected levels of sex hormones was related more to their hormonal levels than to their menopausal status or their age. Thus future epidemiological screenings of women exposed to higher levels of menopause-related health risks should be expanded beyond the estimation of menopausal status based only on menstrual history to include sex hormone level assessment, as well as body composition analysis.

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“…This estimation of the age at menopause in Hungary fits this European interval and the former meta-analysis estimation of age at menopause for the European region (50.79 years) [87].…”

Section: Discussionsupporting

confidence: 81%

Body fatness and endogenous sex hormones in the menopausal transition

et al. 2016

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“…We should first address the finding that the females were able to achieve the same 100-km running performance time until the age of 54 years. At the age of 50, females are generally perior postmenopausal (Bernis and Reher 2007;Dratva et al 2009). In recent years, the age at menopause has increased (Dratva et al 2009).…”

Section: Discussionmentioning

confidence: 99%

“…At the age of 50, females are generally perior postmenopausal (Bernis and Reher 2007;Dratva et al 2009). In recent years, the age at menopause has increased (Dratva et al 2009). This might be a reason why the female peak performance has been maintained in the older age groups.…”

Section: Discussionmentioning

confidence: 99%

Age-related changes in 100-km ultra-marathon running performance

Knechtle

Rüst

Rosemann

et al. 2011

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The aims of this study were (1) to investigate the participation and performance trends at the '100 km Lauf Biel' in Switzerland from 1998 to 2010, and (2) to compare the age-related changes in 100-km running performance between males and females. For both sexes, the percent of finishers significantly (P<0.01) decreased for the 18-29 and the 30-39-year age groups, while it significantly (P<0.01) increased for the 40-49 and the 50-59-year age groups over the studied period. From 1998 to 2010, the mean age of the top ten finishers increased by 0.4 years per annum for both females (P=0.02) and males (P=0.003). The running time for the top ten finishers remained stable for females, while it significantly (P=0.001) increased by 2.4 min per annum for males. There was a significant (P<0.001) age effect on running times for both sexes. The best 100-km running times was observed for the age comprised between 30 and 49 years for males, and between 30 and 54 years for females, respectively. The age-related decline in running performance was similar until 60-64 years between males and females, but was greater for females compared to males after 65 years. Future studies should investigate the lifespan from 65 to 75 years to better understand the performance difference between male and female master ultra-marathoners.

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“…However, there is no consistent conclusion yet on how estrogen level and menopause status would change ACE activity. 42 --44 In addition, extra analyses on women p45 years old (N ¼ 74), who are likely not in menopause, 45 and the remaining women (46 --49 years old, N ¼ 21) in our cohort, showed that there was no difference in the relation of ACE change and weight maintenance (data not shown). Nevertheless, we could not draw any conclusion about the effect of menopause on the prediction power of ACE change based on the Diogenes study.…”

Section: Discussionmentioning

confidence: 99%

Circulating ACE is a predictor of weight loss maintenance not only in overweight and obese women, but also in men

et al. 2012

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, on behalf of Diogenes consortium 14 BACKGROUND: Circulating angiotensin-converting enzyme (ACE) was identified as a predictor of weight loss maintenance in overweight/obese women of the Diogenes project. OBJECTIVE: To investigate whether ACE acted also as a predictor in men of the Diogenes study and to compare it with that in women. DESIGN: Subjects, who lost X8% of body weight induced by low-caloric diet in an 8-week weight loss period, were assigned to weight loss maintenance with dietary intervention for 6 months. SUBJECTS: 125 overweight/obese healthy men from eight European countries who completed whole intervention. MEASUREMENTS: Concentrations and activity of serum ACE at baseline and after the 8-week weight loss, in addition to anthropometric and physiological parameters. RESULTS: Serum ACE concentration decreased by 11.3±10.6% during the weight loss period in men. A greater reduction is associated with less body weight regain during the maintenance period (r ¼ 0.227, P ¼ 0.012). ACE change was able to predict a weight regain p20% after 6 months, with an odds ratio of 1.59 (95% confidence interval (CI): 1.09 --2.33, P ¼ 0.016) for every 10% reduction, which was independent of body mass index and weight loss. The prediction power was weaker in men than in women, but without a significant sex difference (P ¼ 0.137). In pooled subjects (N ¼ 218), the odds ratio was 1.96 (95% CI: 1.46 --2.64, Po0.001). CONCLUSIONS: A greater reduction of ACE during weight loss is favorable for weight maintenance in both men and women. This can offer useful information for personalized advice to improve weight loss maintenance. It also confirms the role of ACE in the metabolic pathways of weight regulation.

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Is age at menopause increasing across Europe? Results on age at menopause and determinants from two population-based studies

Cited by 207 publications

References 41 publications

Body fatness and endogenous sex hormones in the menopausal transition

Body fatness and endogenous sex hormones in the menopausal transition

Age-related changes in 100-km ultra-marathon running performance

Circulating ACE is a predictor of weight loss maintenance not only in overweight and obese women, but also in men

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