Is adolescent alcohol use associated with self-reported hypomanic symptoms in adulthood? – Findings from a prospective birth cohort

Fasteau, Melissa; Mackay, Daniel; Smith, Daniel J.; Meyer, Thomas D.

doi:10.1016/j.psychres.2017.05.034

Cited by 4 publications

(3 citation statements)

References 43 publications

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“…This prevalence of binge alcohol drinking occurs at a critical period during development when the central nervous system is undergoing rapid adaptations in structure and function that could lead to vulnerability to mental disorders, such as anxiety. Epidemiological studies have shown that insidious alcohol use in adolescence predicts a vulnerability to mood disorders in adulthood [4].…”

Section: Introductionmentioning

confidence: 99%

Nucleus accumbens shell small conductance potassium channels underlie adolescent ethanol exposure-induced anxiety

Shan

Galaj

2019

Neuropsychopharmacol.

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Alcohol use typically begins in adolescence, increasing the likelihood of adult mental disorders such as anxiety. However, the cellular mechanisms underlying the consequences of adolescent alcohol exposure as well as the behavioral consequences remain poorly understood. We examined the effects of adolescent or adult chronic intermittent ethanol (CIE) exposure on intrinsic excitability of striatal medium-sized spiny neurons (MSNs) and anxiety levels. Rats underwent one of the following procedures: (1) light–dark transition (LDT) and open-field (OF) tests to evaluate anxiety levels and general locomotion; (2) whole-cell patch clamp recordings and biocytin labeling to assess excitability of striatal MSNs, as well as morphological properties; and (3) western blot immunostaining to determine small conductance (SK) calcium-activated potassium channel protein levels. Three weeks, but not 2 days, after CIE treatment, adolescent CIE-treated rats showed shorter crossover latency from the light to dark side in the LDT test and higher MSN excitability in the nucleus accumbens shell (NAcS). Furthermore, the amplitude of the medium afterhyperpolarization (mAHP), mediated by SK channels, and SK3 protein levels in the NAcS decreased concomitantly. Finally, increased anxiety levels, increased excitability, and decreased amplitude of mAHP of NAcS MSNs were reversed by SK channel activator 1-EBIO and mimicked by the SK channel blocker apamin. Thus, adolescent ethanol exposure increases adult anxiety-like behavior by downregulating SK channel function and protein expression, which leads to an increase of intrinsic excitability in NAcS MSNs. SK channels in the NAcS may serve as a target to treat adolescent alcohol binge exposure-induced mental disorders, such as anxiety in adulthood.

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Section: Introductionmentioning

confidence: 99%

Nucleus accumbens shell small conductance potassium channels underlie adolescent ethanol exposure-induced anxiety

Shan

Galaj

2019

Neuropsychopharmacol.

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“…The remaining associations were aggregated into a more inclusive category relating to substance use and mental health. Two articles reported that higher levels of alcohol [50] and cannabis use [51] at ages 16-17 were positively associated with hypomanic symptoms at ages 22-23.…”

Section: Other Substance Use and Mental Healthmentioning

confidence: 99%

How are young people’s mental health related to their sexual health and substance use? A systematic review of UK literature

Harmanci

Edelman

Richardson

et al. 2023

International Journal of Adolescent Medicine and Health

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Objectives The transition from childhood to adulthood is complex and presents challenges to young people’s mental health. Mental health impacts and is impacted by a range of contextual and personal factors. Adolescence and young adulthood also coincide with increased experimentation with sex, sexuality and substance use. Addressing the mental health, sexual health and substance-use challenges experienced by young people therefore necessitates an understanding of how these elements relate to one another. By collecting and analysing existing literature, this review aims to identify associations between young people’s mental health and sexual health, their mental health and substance use and any resulting gaps-in-knowledge. Content Seven electronic databases were searched between March and May 2021 and updated in May 2022 with terms collated under the categories of “young people”, “mental health”, “sexual health” and “substance use”. English-language articles, presenting data from the UK & Ireland, on young people aged 16–24 years inclusive were screened and subjected to a selection process in accordance with PRISMA guidelines (preregistered on PROSPERO, ref. number CRD42021245096). The quality of the resulting articles were assessed using the Mixed Methods Appraisal Tool (MMAT) and findings were tabulated through a data extraction process. Summary 27 articles were included in the review. Various mental health indices such as depression, anxiety, self-harm, psychotic-like experiences, hypomanic symptoms and binge-purge type eating disorders were found to be associated with higher use of substances such as alcohol, cannabis, ecstasy and generalised drug use. Additionally, mental health indices such as depression, anxiety and self-harm were found to be associated with sex before age 16 and/or unprotected sex at age 16, positive Chlamydia infection and higher levels of sexual activity at a younger age. Overall, cross-sectional associations were stronger than the longitudinal associations presented in the articles. Outlook This review into the specific relations between young people’s mental health, sexual health and substance use has revealed the complex and bi-directional nature of these associations, with some conditions and substances having been more extensively investigated (e.g., alcohol and depression/anxiety) as opposed to the relations between young people’s sexual health and mental health which is lacking in the UK and Irish context. The findings can help inform mental health related policies and service provisions targeted at young people in the UK and Ireland. Areas for future work are suggested.

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“…Interestingly, another study has suggested that the relationship between alcohol use and depression may be mediated by a specific measure of alcohol involvement, whereby problematic use (defined by adverse consequences of alcohol use), but not alcohol intake (defined by the level of alcohol consumption) predicted young adult MDD (Mason et al, 2008 ). Self-reported alcohol use in adolescence has also been prospectively associated with hypomanic/manic symptoms at age 23 (Fasteau et al, 2017 ); however, these results solely relied on self-reported alcohol intake and problematic use and will need to be confirmed in future studies with more robust designs. Although the neural basis for the association between adolescent alcohol use and mood disorders has been largely unexplored, AUD symptom severity in adolescents was associated with increased amygdala responses to emotional compared to neutral stimuli (Aloi et al, 2018 ).…”

Section: Alcoholmentioning

confidence: 99%

Adolescent Substance Use and the Brain: Behavioral, Cognitive and Neuroimaging Correlates

Hamidullah

Thorpe

Frie

et al. 2020

Front. Hum. Neurosci.

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Adolescence is an important ontogenetic period that is characterized by behaviors such as enhanced novelty-seeking, impulsivity, and reward preference, which can give rise to an increased risk for substance use. While substance use rates in adolescence are generally on a decline, the current rates combined with emerging trends, such as increases in e-cigarette use, remain a significant public health concern. In this review, we focus on the neurobiological divergences associated with adolescent substance use, derived from a cross-sectional, retrospective, and longitudinal studies, and highlight how the use of these substances during adolescence may relate to behavioral and neuroimaging-based outcomes. Identifying and understanding the associations between adolescent substance use and changes in cognition, mental health, and future substance use risk may assist our understanding of the consequences of drug exposure during this critical window.

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Is adolescent alcohol use associated with self-reported hypomanic symptoms in adulthood? – Findings from a prospective birth cohort

Cited by 4 publications

References 43 publications

Nucleus accumbens shell small conductance potassium channels underlie adolescent ethanol exposure-induced anxiety

Nucleus accumbens shell small conductance potassium channels underlie adolescent ethanol exposure-induced anxiety

How are young people’s mental health related to their sexual health and substance use? A systematic review of UK literature

Adolescent Substance Use and the Brain: Behavioral, Cognitive and Neuroimaging Correlates

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