Is a small coil more effective as a finishing coil for the embolization of intracranial aneurysms? Outcomes using GALAXY G3™ MINI micro-coils as finishing coils in a single center

Abstract

Objective The purpose of this study was to compare the outcomes of coil embolization using a 0.009 inches primary outer diameter coil as finishing coil (FC) to that of 0.01 inches. Methods From February and August 2020, 131 aneurysms that performed coil embolization using FC with a second loop diameter of 1 mm, were reviewed retrospectively, conducting propensity score matching and logistic regression analysis. Angiographic results such as, occlusion grade, packing density, failure and event were compared between 0.009 inches coil of GALAXY G3™ MINI microcoil (n = 54) and 0.01 inches coils (n = 77). Results There were no statistically significant differences between two groups, but more events occurred in the 0.009 group. (Odds ratio, 3.65; 95% CI, 1.06-12.55; P = 0.031) In the results of coil embolization, successful occlusion occlusion (complete occlusion and residual neck) was identified more in the 0.01 group. After propensity score matching, the variables in each group were similar, but the successful occlusion was higher in the 0.01 group as in the total population. Events tended to occur more frequently in the 0.009 inch group, and logistic regression analysis showed slightly higher events in the angled microcatheter. (48.3% versus 76.9%., P = 0.075), Also, the 0.009 inch FC is an independent risk factor. (Odds ratio, 3.84; 95% CI, 1.07-13.80; P = 0.039) Conclusions Using 0.01 inches coils as FC increased the packing density after the procedure, and showed more successful occlusion than using a 0.009 inches coil. The probability of unexpected events was observed more than three times in the 0.009 inch group.

Mid-term safety and efficacy in small intracranial aneurysm coiling: results from TARGET® nano prospective independent core lab adjudicated multicenter registry

“…Kim and colleagues, in a propensity-score matched analysis, investigated outcomes in patients treated with Target Nano coils vs. The Galaxy G3TM MINI micro-coil (GM; Cerenovus, Irvine, CA, United States) ( 23 ). Authors reported a safe profile for patients treated with Target Nano coils, with comparable PD to the current registry.…”

“…A total of 12 clinical sites within the United States with active IRB approval to participate in the TARGET Registry with 11 centers enrolling at least 1 patient, the median [IQR] aneurysms per clinical site was 12 [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. Mercy St. Vincent Medical Center, Toledo, Ohio served as the coordinating center for TARGET Nano Registry.…”