Is a simplified version of PsAMRIS (sPsAMRIS) a potential tool for therapy monitoring in established psoriatic arthritis?

Abstract

Background: To evaluate whether a simplified version of the psoriatic arthritis magnetic resonance imaging score (PsAMRIS), sPsAMRIS, is a potential tool for therapy monitoring in psoriatic arthritis (PsA). Methods: Seventeen patients with PsA, according to CASPAR classification criteria, with inadequate methotrexate response received anti-TNF treatment and were assessed by 3T MRI of the clinically dominant hand at baseline and after 6 months. Scoring was according to PsAMRIS. Items were reduced based on standard response mean (SRM), resulting in a simplified PsAMRIS (sPsAMRIS), which was compared to PsAMRIS by calculation of the total SRM and relative efficiency (RE) after bootstrapping. Results: The PsAMRIS subscore of MCP3, 4, and PIP4 resulted in the highest SRM (–0.07 each) and were, therefore, included in sPsAMRIS. sPsAMRIS had a higher SRM compared to PsAMRIS (–0.13 vs. –0.02) and a higher RE (29.46). PsAMRIS and sPsAMRIS were highly correlated at baseline (r=0.75, p<0.01) and follow-up (r=0.64, p=0.01). The evaluation time was reduced from 471 to 142 seconds at baseline and from 478 to 133 seconds at follow-up (p<0.001). Conclusions: sPsAMRIS is a potential tool for therapy monitoring in psoriatic arthritis and is a time-saving variation of OMERACT PsAMRIS.

Cartilage Degradation in Psoriatic Arthritis Is Associated With Increased Synovial Perfusion as Detected by Magnetic Resonance Imaging

“…The same study population has been included in a different study. However, this study has been published as a pre-print only (19).…”