We investigate the dynamics of the Higgs field at the end of inflation in the minimal scenario consisting of an inflaton field coupled to the Standard Model only through the non-minimal gravitational coupling ξ of the Higgs field. Such a coupling is required by renormalisation of the Standard Model in curved space, and in the current scenario also by vacuum stability during high-scale inflation. We find that for ξ 1, rapidly changing spacetime curvature at the end of inflation leads to significant production of Higgs particles, potentially triggering a transition to a negative-energy Planck scale vacuum state and causing an immediate collapse of the Universe.PACS numbers: 98.80. Cq, 04.62.+v The Standard Model (SM) of particle physics can be consistently extrapolated to the Planck scale without any new physics, but the current measurements of the Higgs boson and top quark masses suggest that the current vacuum state of the Universe would then not be stable. This instability depends sensitively on the top mass m t , which is subject to significant experimental and theoretical uncertainty [19], but for the best fit values, the Higgs potential turns negative above the instability scale Λ I ∼ 1011 GeV [21]. This implies that the current vacuum would eventually decay into a negative-energy Planck scale true vacuum, but its lifetime exceeds the age of the universe by a wide margin [1].Whether such a metastable universe could have survived the cosmological evolution, especially inflation, has recently attracted significant interest [3][4][5]. In most of the simplest models of inflation, the Hubble rate during inflation is comparable to the current upper bound H 9 × 10 13 GeV [8]. It may therefore well be above the instability scale, in which case production of Higgs fluctuations could push the field over the potential barrier into the true Planck-scale vacuum [3]. This instability problem is exacerbated by spacetime curvature induced running of the couplings, which makes the Higgs selfcoupling negative even at low field values [4][5][6].Notably, vacuum stability can still be maintained even during inflation without any new physics coupled to the SM fields [4], thanks to the Higgs-curvature coupling ξRĤ †Ĥ . This coupling is inevitably generated by radiative corrections and when assuming the SM to be valid up to the Planck scale it is the only relevant new term when probing sub-Planckian scales. The current experimental constraints are extremely weak, |ξ| 2.6×1015 [7]. With a positive coupling, this term increases the height of the potential barrier between the vacua, thereby increasing the lifetime of the metastable vacuum. Vacuum stability is maintained for all inflationary scales compatible with the tensor bound [8], provided the electroweak scale value of the running coupling ξ(µ) lies above ξ EW 0.1 [4].In this letter, we investigate the instability problem at the end of inflation, again assuming no new physics or higher-dimensional operators but taking the gravitational coupling ξ into account. In contrast with...