Is a Cholestrol‐Enriched Diet a Risk Factor for Alveolar Bone Loss?

Abstract

Although any additive effect of cholesterol-enriched diet to ABL was not found in rats with ligature-induced experimental periodontitis, these findings revealed that a cholesterol-enriched diet could lead to ABL and an increase in periodontal inflammation and serum pro-oxidants.

Effects of rosuvastatin on inducible nitric oxide synthase in rats with hyperlipidaemia and periodontitis

“…42 Recent studies have reported that hyperlipidaemia in rats results in ABL without periodontitis. 11,12 Although Cavagni et al 11 In the present study, ABL was observed in Group Hy. Also, there were a larger number of iNOS(+) cells in gingival tissues of rats in Group…”

“…Recent studies have reported that hyperlipidaemia in rats results in ABL without periodontitis . Although Cavagni et al reported that hyperlipidaemia increased ABL in periodontitis, Kırzıoğlu et al did not find the same result.…”

“…Recent studies have reported that hyperlipidaemia in rats results in ABL without periodontitis . Although Cavagni et al reported that hyperlipidaemia increased ABL in periodontitis, Kırzıoğlu et al did not find the same result. Popkov et al observed higher gingival iNOS activity in an experimental periodontitis rat model, with or without alloxan diabetes and exogenous hypercholesterolemia, than in control rats; however, no significant difference in iNOS activity was found between rats with induced periodontitis and those with induced periodontitis + diabetes and exogenous hypercholesterolemia.…”

“…Hyperlipidaemia is a proinflammatory state in which increased oxidative stress and endothelial dysfunction is seen . Some studies have reported that hyperlipidaemia in rats results in alveolar bone loss (ABL) without periodontitis …”

“…10 Some studies have reported that hyperlipidaemia in rats results in alveolar bone loss (ABL) without periodontitis. 11,12 Rosuvastatin is a statin that strongly inhibits 3-hydroxy-3-met hylglutaryl-coenzyme A reductase, which is widely used to reduce cholesterol levels. Rosuvastatin also has antioxidant and immunomodulatory effects.…”