Is 50 Gy Sufficient to Achieve Long-Term Local Control after Incomplete Resection of Typical Neurocytomas?

Rades, Dirk; Schild, Steven E.

doi:10.1007/s00066-006-1522-z

Cited by 17 publications

(14 citation statements)

References 17 publications

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“…Radiotherapy and radiosurgery-Since central neurocytomas are usually benign with low proliferative potential, radiotherapy is not theoretically necessary. However, there are several reports claiming that postoperative radiotherapy for central neurocytoma leads to the disappearance or shrinkage of residual tumors [26][27][28][42][43]45]. Radiotherapy after grossly total resection remains controversial since most patients have long-term tumor control without radiotherapy.…”

Section: Treatment Options and Outcomementioning

confidence: 99%

“…Additionally, unlike larger field of brain irradiation for adjuvant radiotherapy, radiosurgery spares regional structures including the fornix, thalamic and basal ganglia nuclei, and the deep frontal lobe from delayed radiation effects [31]. Even with limited follow-up, it appears that for small, residual, or recurrent tumors, radiosurgery is a reasonable treatment option [36,40,[42][43][44][45].…”

Section: Treatment Options and Outcomementioning

confidence: 99%

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Central neurocytoma: A clinical, radiological and pathological study of nine cases

Chen¹,

Shen²,

Wang³

et al. 2008

Clinical Neurology and Neurosurgery

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Purpose-Central neurocytoma is a rare intraventricular brain tumor that affects young adults and presents with increased intracranial pressure secondary to obstructive hydrocephalus. Typically, it has a favorable prognosis after adequate surgical intervention, but in some cases the clinical course is more aggressive. In this report, we describe the diagnosis and treatment of central neurocytoma in a series of patients at our institution.Patients and Methods-Our series of nine patients (M:F=2:7, mean age, 28.2 years) with ventricular tumors showed typical radiological, histologic and immunohistochemical features of central neurocytoma. Most patients received craniotomy with removal of the tumor through transcallosal or transcortical approach. The surgical and histopathologic data of these patients were reviewed and analyzed.Results-The prognosis is generally favorable. Although most patients were alive and well at the last follow-up, two developed recurrence. Typical histologic features of recurrent neurocytoma include high proliferative activity (MIB-1 labeling index: 2.0-6.8%), prominent vascular proliferation and remarkable synaptophysin expression. Two patients (non-recurrent) died during follow-up due to sepsis or central failure. The MIB-1 labeling indices were as high as 2.2-5.4% for these two patients.Conclusion-Although central neurocytoma is generally a benign neoplasm, some variant forms of recurrence are also present. Complete resection provides favorable long-term prognosis in most cases. Recurrent tumors are often local and the patients seem to recover well after a second resection followed by radiotherapy. Histologic features such as tumor proliferation (MIB-1 labeling index), vascular proliferation, and synaptophysin expression are often prominent in the recurrent tumor. We recommend that these histologic features be considered for tumor recurrence during treatment and follow-up of these patients.

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Section: Treatment Options and Outcomementioning

confidence: 99%

Section: Treatment Options and Outcomementioning

confidence: 99%

Central neurocytoma: A clinical, radiological and pathological study of nine cases

Chen¹,

Shen²,

Wang³

et al. 2008

Clinical Neurology and Neurosurgery

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“…Various neuro-oncologic diseases such as metastatic spinal cord compression (MSCC), cerebral metastases, and brain tumors may lead to neurologic deficits [5,14,18,19]. Twenty to 40% of cancer patients develop metastases within the brain.…”

Section: Introductionmentioning

confidence: 99%

Whole-Brain Radiotherapy with 20 Gy in 5 Fractions for Brain Metastases in Patients with Cancer of Unknown Primary (CUP)

et al. 2007

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“…Since extraventricular neurocytomas are usually benign with low proliferative potential, radiotherapy is not theoretically necessary. However, there are several reports claiming that postoperative radiotherapy for neurocytoma leads to the disappearance or shrinkage of residual tumors 31,33 . Reports on chemotherapy for central neurocytoma have been limited 32 .…”

Section: Discussionmentioning

confidence: 99%

Cerebellar Extraventricular Neurocytoma With Spinal Seeding

Şeker¹,

Tanrıkulu²,

Yener³

et al. 2011

MMJ

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Central neurocytomas are typically located in lateral or third ventricles. Here, we report a case of neurocytoma located in the middle cerebellar peduncle. A 36-year-old male patient presented with symptoms of ataxic gait and urinary incontinence for one month. Magnetic resonance imaging (MRI) of the brain revealed a slightly enhanced lesion on the left middle cerebellar peduncle with obstructive hydrocephalus. The preoperative diagnosis was a glial tumor and a subtotal surgical removal was performed. Following pathological studies, the final definitive diagnosis was made as central neurocytoma. Six months after surgery, the patient presented with low back pain and bilateral lower extremity weakness. Lumbar MRI studies revealed multiple intradural-extramedulary lesions. The patient was not operated for spinal lesions. He was treated with palliative radiotherapy in the metastatic spinal area. Cerebellar peduncle is an atypical location for a neurocytoma. Neurocytomas in atypical locations may behave more aggressively and make spinal seeding. According to neuroradiological and clinical presentation, these tumors may have been confused with other common cerebellar lesions. Pathological examination is needed for definitive diagnosis. Favorable prognosis is related to total tumor excision.

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Is 50 Gy Sufficient to Achieve Long-Term Local Control after Incomplete Resection of Typical Neurocytomas?

Abstract: After incomplete resection of typical neurocytomas, radiotherapy with 50 Gy (2-Gy fractions) appears sufficient, as it resulted in similar local control as doses > 50 Gy and insignificantly better local control than doses < 50 Gy.

Cited by 17 publications

References 17 publications

Central neurocytoma: A clinical, radiological and pathological study of nine cases

Central neurocytoma: A clinical, radiological and pathological study of nine cases

Whole-Brain Radiotherapy with 20 Gy in 5 Fractions for Brain Metastases in Patients with Cancer of Unknown Primary (CUP)

Cerebellar Extraventricular Neurocytoma With Spinal Seeding

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