Is 20/20 visual outcome a reality in rubella cataract? - Prognostic factors in children with cataract associated with congenital rubella syndrome

Joshi, Deepak; Krishnaprasad, R; Agrawal, Apeksha

doi:10.4103/ijo.ijo_903_20

Cited by 4 publications

(6 citation statements)

References 14 publications

(10 reference statements)

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“…A large number of interventional workers do not wear lead protective glasses during surgery, resulting in direct exposure of eyes to radiation. In order to make interventional radiology workers aware of the harm of radiation to eye lens, enhance their awareness of eye protection at work, reduce radiation dose, and ensure their health [2]. Figure 1 shows percutaneous coronary intervention.…”

Section: Introductionmentioning

confidence: 99%

Radiation Exposure of Crystalline Bodies during Interventional Therapy and Related Research Status

Chen

Zhao

Zhong

et al. 2022

Contrast Media & Molecular Imaging

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The aim of this study was to estimate the exposure dose level of ocular corpuscles during the common interventional procedures of interventional radiology workers. This article retrospectively analyzed the general instruments and equipment of interventional therapy, the general methods and steps of interventional therapy, and the influence of X-ray of interventional surgery. The related contents of eye protection for interventional radiology workers were summarized. This study found that there was a significant linear correlation between the equivalent dose of lens and the exposure time. The tube voltage, tube current, and the size of fluoroscopic field of vision also have an impact on the radiation of workers during surgical exposure. Interventional surgery is difficult and easy. The exposure time of difficult surgery is relatively long, so the dose received by interventional staff is large. The intervention staff should improve their professional knowledge, be proficient in the operation technology, and try to reduce the exposure without affecting the diagnosis and treatment effect. During the intervention operation, the eye substance of the operator is exposed to a certain dose of radiation, and the wearing rate of protective lead glasses of the intervention staff is very low. Therefore, we must pay attention to the protection of the eyes, strengthen the protection management, and reduce the exposure dose of the intervention staff as much as possible.

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Section: Introductionmentioning

confidence: 99%

Radiation Exposure of Crystalline Bodies during Interventional Therapy and Related Research Status

Chen

Zhao

Zhong

et al. 2022

Contrast Media & Molecular Imaging

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“…17 Microphthalmos and microcornea are most likely caused by a virus-induced delay in maturation and replication of the affected cells, which can also be referred to as "failure to thrive" on a larger scale. 19 Other ocular manifestations in this study include retinopathy pigmentary, which was found in 20% of patients. The reported rate of retinopathy pigmentary in CRS varies greatly.…”

Section: Discussionmentioning

confidence: 73%

Profile of Unilateral Cataract in Children With Congenital Rubella Syndrome

Yulia

Kirana²,

Soeharto³

2022

J. prof. medika

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A congenital cataract is preventable blindness in children and is associated with intrauterine rubella infection known as congenital rubella syndrome (CRS), mostly found in developing countries. This study aims to describe the profile of unilateral cataracts in children with CRS, which are more difficult to manage than bilateral ones. As a retrospective study, we reviewed complete medical records of children with CRS and unilateral cataracts at Cipto Mangunkusumo hospital from 2017 to 2020. Fifteen patients were included, mostly male and from outside Jakarta.The mean age of onset was 2.9 months, while the average age at first presentation and surgery was 27.7 months and 29.1 months, respectively.No correlation was found between patients’ residential distance from the hospital towards duration between onset of symptoms and first presentation to the hospital. 100% and 66.7% of patients had leukocoria and microcornea as ocular manifestations. The majority of systemic manifestations are congenital heart disease.66.7% of children underwent cataract surgery without IOL implantation. Improvement of visual acuity postoperatively was observed in 13.3% of patients, and 66.7% of patients used contact lenses for visual rehabilitation. 60% of patients had posterior capsule opacity within six months of follow-up. The challenge of wearing contact lenses in children makes the risk of amblyopia even greater

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“…More than a million children in Asia are blind due to pediatric cataracts [ 20 ]. Rubella is a common inherited infection causing congenital cataracts and an important cause of lifelong visual deprivation in developing countries [ 21 , 22 ]. Children with congenital cataracts can still acquire the best visual acuity if they undergo a well-defined treatment protocol regarding the time of surgery, postsurgical visual rehabilitation, with proper and prompt management of complications [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…Rubella is a common inherited infection causing congenital cataracts and an important cause of lifelong visual deprivation in developing countries [ 21 , 22 ]. Children with congenital cataracts can still acquire the best visual acuity if they undergo a well-defined treatment protocol regarding the time of surgery, postsurgical visual rehabilitation, with proper and prompt management of complications [ 22 ]. A five-year study conducted in Yogyakarta, Indonesia, found that 66.7% of laboratory-confirmed CRS cases had congenital cataracts [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…A five-year study conducted in Yogyakarta, Indonesia, found that 66.7% of laboratory-confirmed CRS cases had congenital cataracts [ 23 ]. The cataract condition may be unilateral or bilateral, and the most common morphologies were total, zonular, and membranous cataracts [ 22 ]. Unfortunately, the cataract case finding in this patient was very late because the patient came to the hospital with light perception in visual acuity.…”

Section: Discussionmentioning

confidence: 99%

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Phylogenetic analysis of congenital rubella virus from Indonesia: a case report

et al. 2022

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Background Rubella is a common inherited infection resulting in congenital cataracts and a significant cause of permanent vision loss in developing countries. In 2016, Indonesia had the highest number of congenital rubella syndrome (CRS) cases globally. Here, we report the first genotype of the rubella virus extracted from the eye lens from a child with congenital cataracts due to CRS. Case presentation A female neonate was delivered by an elective caesarean delivery with normal birth weight at term from a 24-year-old mother in the rural setting. The baby presented with bilateral congenital cataracts, small-moderate secundum atrial septal defect, severe supravalvular pulmonary stenosis, and profound bilateral hearing loss. She also had microcephaly and splenomegaly. The patient's serology showed persistent positive IgG for rubella virus at the age of four years and four months. Following extraction during cataract surgery, viral detection of the lenses identified the presence of rubella. Phylogenetic analysis confirmed that the virus was grouped into genotype 1E. Conclusions Our study reports the first phylogenetic analysis of the rubella virus extracted from the eye lens of a child with CRS in Indonesia. The detection of the rubella virus from eye lenses is remarkably promising. Our findings also emphasize the importance of molecular epidemiology in tracking the origin of rubella infection toward achieving virus eradication.

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Is 20/20 visual outcome a reality in rubella cataract? - Prognostic factors in children with cataract associated with congenital rubella syndrome

Cited by 4 publications

References 14 publications

Radiation Exposure of Crystalline Bodies during Interventional Therapy and Related Research Status

Radiation Exposure of Crystalline Bodies during Interventional Therapy and Related Research Status

Profile of Unilateral Cataract in Children With Congenital Rubella Syndrome

Phylogenetic analysis of congenital rubella virus from Indonesia: a case report

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