Is 18F-FDG PET/CT Useful for Distinguishing Between Primary Thyroid Lymphoma and Chronic Thyroiditis?

Nakadate, Masashi; Yoshida, Katsuya; Ishii, Akihiro; Koizumi, Masayuki; Tochigi, Naobumi; Suzuki, Yoshio; Ryu, Yoshiharu; Nakagawa, Takayuki; Umehara, Isao; Shibuya, Hitoshi

doi:10.1097/rlu.0b013e31829b2686

Cited by 30 publications

(8 citation statements)

References 29 publications

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“…In a recent 18 F-FDG PET/ CT study, malignant lymph nodes were reported to display higher HU compared to the benign ones in lung cancer [22]. In another 18 F-FDG PET/CT study, the CT density in primary thyroid lymphoma was found to be lower than that measured in chronic thyroiditis [23]. All the above mentioned studies demonstrate that CT density measurements are irreplaceable components of 18 F-FDG PET/CT imaging and the threshold or mean HU values differ significantly from one malignant tumor type to the other.…”

Section: Discussionmentioning

confidence: 88%

Total Lesion Glycolysis on 18F-FDG PET/CT of Women with Non-Locally Advanced Breast Cancer: Does it Correlate with CT Density of the Lesion?

Ayaz

2019

Zeynep Kamil Tıp Bülteni

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Objective: Breast cancer (BC) is the second most frequent malignancy in women. Fluorine-18-fluorodeoxyglucose (18 F-FDG) positron emission tomography (PET)/computed tomography (CT) has become a major diagnostic tool for staging of the disease and predicting the prognosis. We aimed to evaluate the correlation between main quantitative 18 F-FDG PET/CT parameters-primarily TLG (total lesion glycolysis), and CT density measurements as Hounsfield Unit (HU) of the primary BC masses in non-locally advanced BC (non-LABC) patients. And also we aimed to see whether there is a correlation between the volume and HU measurements of BC masses in non-LABC patients. Material and Methods: In this retrospective study, we included 17 women with unilateral non-LABC having a mean age of 54.1±10.3 years who underwent 18 F-FDG PET/CT before any treatment between 2016−2017. The mean volume, HU, maximum standardized uptake value (SUVmax) and TLG of the primary BC masses with their standard deviations and 95% confidence intervals (CI)s were calculated. Of the BC masses, the correlations between their mean TLG and mean HU, their mean SUVmax and mean HU, their mean volume and mean HU were statistically calculated.

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Section: Discussionmentioning

confidence: 88%

Total Lesion Glycolysis on 18F-FDG PET/CT of Women with Non-Locally Advanced Breast Cancer: Does it Correlate with CT Density of the Lesion?

Ayaz

2019

Zeynep Kamil Tıp Bülteni

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“…Recent studies have suggested that FDG-PET has superior accuracy in staging of lymphoma compared to computed tomography or magnetic resonance imaging (25). It may provide more accurate staging in thyroid lymphoma (26,27); therefore, some patients in our study might be diagnosed as having more advanced clinical stage lymphoma. Future studies will allow a proper interpretation.…”

Section: Discussionmentioning

confidence: 89%

Rituximab-Including Combined Modality Treatment for Primary Thyroid Lymphoma: An Effective Regimen for Elderly Patients

Watanabe

Narimatsu

Noh

et al. 2014

Thyroid

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Background: Primary thyroid lymphoma (PTL) develops mostly in middle-aged and older females. However, the optimal treatment for elderly patients with diffuse large B-cell lymphoma (DLBCL), which accounts for most PTL cases, is unclear. Rituximab is a promising drug that, in combination with traditional combination therapy, has demonstrated an increased antitumor effect without a substantial increase in toxicity. In this study, treatment outcomes of elderly patients with thyroid DLBCL who underwent rituximab-including combination therapy were analyzed. , and prednisolone 100 mg/body) and involved field irradiation were planned. Treatment outcomes of these patients were retrospectively reviewed. Results: Two patients terminated the treatment because of interstitial pneumonia during R-CHOP therapy. Only one patient showed treatment resistance and the regimen was changed; 42 patients (98%) responded to the treatment. Five-year overall survival and event-free survival were 87% (95% confidence interval [95% CI], 64-96%) and 74% (95% CI, 50-89%), respectively. Conclusion: The results of the present study indicate that rituximab-including combination therapy was effective for elderly patients with thyroid DLBCL. A multicenter, long-term observational study is needed to confirm this, and additional refinement of the treatment protocol is required to optimize the antitumor effect.

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“…However, a recent study in a large patient group revealed that SUV max was significantly higher and CT density was lower in primary thyroid lymphoma as compared to chronic thyroiditis. The authors have thus suggested that 18 F-FDG PET/CT may be helpful in distinguishing primary thyroid lymphoma from chronic thyroiditis (45). Similarly, a large series of thyroid lymphoma from a single center have been recently reported.…”

Section: Thyroid Lymphomamentioning

confidence: 99%

18F-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography for Other Thyroid Cancers: Medullary, Anaplastic, Lymphoma and So Forth

Araz

Çayir²

2017

Mirt

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Positron emission tomography/computed tomography (PET/CT) with 18F-fluorodeoxyglucose (FDG) is used in staging, restaging, and evaluation of therapy response in many cancers as well as differentiated thyroid carcinomas especially in non-iodine avid variants. Its potential in less frequent thyroid tumors like medullary, anaplastic thyroid cancers, thyroid lymphoma and metastatic tumors of the thyroid however, is not well established yet. The aim of this review is to provide an overview on the recent applications and indications of 18F-FDG PET/CT in these tumors and to focus on the controversies in the clinical setting.

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Is 18F-FDG PET/CT Useful for Distinguishing Between Primary Thyroid Lymphoma and Chronic Thyroiditis?

Abstract: The SUV(max) was significantly higher and the CT density was significantly lower in PTL as compared with those in chronic thyroiditis. Thus, (18)F-FDG PET/CT may be useful for distinguishing between PTL and chronic thyroiditis.

Cited by 30 publications

References 29 publications

Total Lesion Glycolysis on 18F-FDG PET/CT of Women with Non-Locally Advanced Breast Cancer: Does it Correlate with CT Density of the Lesion?

Total Lesion Glycolysis on 18F-FDG PET/CT of Women with Non-Locally Advanced Breast Cancer: Does it Correlate with CT Density of the Lesion?

Rituximab-Including Combined Modality Treatment for Primary Thyroid Lymphoma: An Effective Regimen for Elderly Patients

18F-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography for Other Thyroid Cancers: Medullary, Anaplastic, Lymphoma and So Forth

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