IRT/IRT as a newborn cystic fibrosis screening method: optimal cutoff points for a mixed population
Carolina Godoy,
Pedro Paulo Brito,
Tatiana Amorim
et al.
Abstract:The Brazilian Unified National Health System (SUS) has incorporated newborn screening for cystic fibrosis since 2001. The protocol involves two samples of immunoreactive trypsinogen (IRT1/IRT2). This study aims to analyze fixed and floating values at the first and second IRT (IRT1/IRT2) cutoff points and assess the accuracy of the IRT/IRT methodology in a population from Northeastern Brazil. Descriptive, individual-level data from the newborn screening reference service data system (2013-2017) were used in thi… Show more
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