Irritative activity of antiinflammatory agents, betamethasone 17-valerate, beclomethasone 17, 21-dipropionate, betamethasone 17, 21-dipropionate, or indomethacin on the gastrointestinal tract in rats and dogs

Okabe, Susumu; Tabata, Keiichi; Ishihara, Yasunobu; Kunimi, Haruyo; Izumi, Kaoru; Uchida, Naotaka

doi:10.1254/fpj.74.773

Folia Pharmacologica Japonica

1978

DOI: 10.1254/fpj.74.773

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Irritative activity of antiinflammatory agents, betamethasone 17-valerate, beclomethasone 17, 21-dipropionate, betamethasone 17, 21-dipropionate, or indomethacin on the gastrointestinal tract in rats and dogs

Susumu Okabe¹,

Keiichi Tabata²,

Yasunobu Ishihara³

et al.

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“…Sugawa et al (2) have shown that aspirin significantly delays the healing of gastric ulcers in the fundus of the stomach in dogs. In contrast, Phillips et (5). The pres ent study was undertaken to determine whether or not indomethacin activates healed ulcers in the dog stomach.…”

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Does Indomethacin Activate Healed Gastric Ulcers in the Dog?

Okabe¹,

Tabata²

1981

Digestion

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Effects of indomethacin on healed or partially healed gastric ulcers in the dog were studied. Gastric ulcers were produced by submucosal injection of 1 ml of 40% acetic acid solution into the bordering area of the fundus and antrum of the stomach. Indomethacin, 20 mg/kg, was given orally once daily for 5 days beginning on the 50th day after ulceration. While erosions or deep ulcers were produced by indomethacin, healed or partially healed acetic acid ulcers were not aggravated. Mechanisms involved in this strong resistance of healed ulcers to the ulcerogenic agent remain to be determined.

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Does Indomethacin Activate Healed Gastric Ulcers in the Dog?

Okabe¹,

Tabata²

1981

Digestion

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Effects of nonsteroidal, antiinflammatory drugs on gastrointestinal injury and prostanoid generation in healthy volunteers

et al. 1988

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A new nonsteroidal, antiinflammatory drug, carprofen, was compared with indomethacin as to their effects on mucosal injury and prostanoid biosynthesis. A prospective, double-blind endoscopy study was performed in 40 healthy adults. After baseline normal endoscopy, 20 subjects were randomly assigned to either indomethacin (25 mg four times daily) or carprofen (150 mg twice daily) for eight days and re-endoscoped. Urinary and gastric mucosal prostaglandin generation, respectively, of PGE2 and PGF2 alpha, and PGE and 6-keto-PGF1 alpha was determined. Minor subjective symptoms occurred in six of 20 indomethacin (including four of eight with gastrointestinal injury) and in three of 20 carprofen subjects. Indomethacin and carprofen reduced gastric and urinary prostaglandin synthesis to a similar degree. Gastrointestinal injury was present in eight of 20 indomethacin and in none of 20 carprofen subjects. This study fails to establish a relationship between duodenal mucosal lesions and gastric prostanoid generation and confirms the lack of correlation between indomethacin-induced duodenal injury and subjective symptomatology. Carprofen appears to produce less objective damage in the upper gastrointestinal tract than indomethacin at comparable clinical doses.

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Review of the toxicology of beclomethasone dipropionate

Libretto¹

1995

Arch Toxicol

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This paper reviews the published toxicity of beclomethasone dipropionate (BDP). BDP is a synthetic glucocorticosteroid which has a powerful local anti-inflammatory effect but little systemic action. It has been developed for both dermatological and inhaled applications. LD50 values and other acute studies indicated low toxicity. Findings published for repeat dose and reproductive toxicity studies embraced the known range of metabolic and physiological effects of glucocorticoids. For repeat dose studies, these included reduction in body weight gains, cushingoid syndrome in dogs, reductions in the numbers of lymphocytes and the weights of the tissues connected with the immune system, and hepatic glycogen deposition and fatty liver changes. In reproductive studies, there was an increase in the prevalence of cleft palate in mice and rabbits and in the number of dead foetuses, and ossification was retarded. Despite the route of administration, there was a general similarity of effects within and between species. All observations were characteristic of synthetic glucocorticoids and related to the intrinsic effects of these drugs.

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Irritative activity of antiinflammatory agents, betamethasone 17-valerate, beclomethasone 17, 21-dipropionate, betamethasone 17, 21-dipropionate, or indomethacin on the gastrointestinal tract in rats and dogs

Cited by 4 publications

References 0 publications

Does Indomethacin Activate Healed Gastric Ulcers in the Dog?

Does Indomethacin Activate Healed Gastric Ulcers in the Dog?

Effects of nonsteroidal, antiinflammatory drugs on gastrointestinal injury and prostanoid generation in healthy volunteers

Review of the toxicology of beclomethasone dipropionate

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