Irritant susceptibility and weal and flare reactions to bioactive agents in atopic dermatitis. II. Influence of season

Tupker, Ron A.; Coenraads, Pieter Jan; Fidler, V.; Jong, M. C. J. M. de; Meer, J. B. Van Der; Monchy, J. G. R. De

doi:10.1111/j.1365-2133.1995.tb02662.x

Cited by 44 publications

(32 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As regards TEWL, Tupker et al [13] found an increase in the winter in both a normal control group and a group of volunteers suffering from atopic dermatitis. The greatly increased winter TEWL found in the present study reflects the poor state of the stratum corneum, characterized by xerosis, loose structure, cracks in the stiff stratum corneum and scratches induced by the incessant itching associated with winter xerosis in the elderly.…”

Section: Discussionmentioning

confidence: 99%

Xerotic Skin of the Elderly: A Summer versus Winter Comparison Based on Biophysical Measurements

Andersen

Andersen²,

Kligman

2003

Exog Dermatol

View full text Add to dashboard Cite

Background: Xerosis, a well-known problem in the elderly part of the population, is often exacerbated in winter with negative effects on daily life. Objective: To describe differences in stratum corneum function of the lower legs in winter compared to summer using objective biometric methods. Methods: The following techniques were utilized: colorimetry, evaporimetry, laser Doppler perfusion imaging, sticky slides (D-Squames^®) and corneometry. The reaction to a 24-hour patch test with sodium lauryl sulfate, burning to chloroform:methanol and the whealing response to dimethylsulfoxide were also studied. Results: In winter, the stratum corneum had a looser structure and a diminished barrier function with an increased neurosensory reactivity. Conclusion: The results suggest that the exacerbation of xerosis in the winter is accompanied by structural changes in the stratum corneum, making it looser and more permeable to chemical irritants with a heightened response to neurosensory stimuli.

show abstract

Section: Discussionmentioning

confidence: 99%

Xerotic Skin of the Elderly: A Summer versus Winter Comparison Based on Biophysical Measurements

Andersen

Andersen²,

Kligman

2003

Exog Dermatol

View full text Add to dashboard Cite

show abstract

“…Higher irritability of the skin in winter has been reported not only in healthy [1,2] but also in atopic subjects [3]. We often hear complaints even from healthy females that their facial skin becomes more irritable during winter.…”

Section: Introductionmentioning

confidence: 99%

The Winter Season Affects More Severely the Facial Skin than the Forearm Skin: Comparative Biophysical Studies Conducted in the Same Japanese Females in Later Summer and Winter

Kikuchi

Kobayashi

Fur³

et al. 2002

Exog Dermatol

View full text Add to dashboard Cite

Skin disorders such as atopic dermatitis, psoriasis and senile xerosis show a tendency to exacerbate in winter. We investigated the seasonal influence on the functional parameters of the skin in healthy female volunteers of different age groups. Biophysical noninvasive measurements, including transepidermal water loss (TEWL) as a parameter for the barrier function of the stratum corneum (SC), high-frequency conductance as a parameter for the hydration state of the SC, temperature, color and casual surface lipid levels, were conducted during the later summer and winter months in 39 healthy adult Japanese females ranging in age from 24 to 78 years. The measurements were made on the cheek, the exposed area, and flexor forearm, the semicovered area, in the same climate-controlled chamber. The barrier function of the SC was found to be significantly impaired in winter both on the cheek and flexor forearm. This difference between summer and winter was much larger on the cheek than on the forearm. The hydration state of the SC was significantly lower in winter on the flexor forearm, whereas no such seasonal change was apparent on the cheek where sebum levels did not show any seasonal change. We measured the corneocyte size in 24 out of the 39 subjects to estimate a seasonal change of the turnover rate of the SC. It tended to be smaller only on the exposed cheek skin, suggesting an enhanced turnover of the SC in winter, whereas it was somewhat larger on the semicovered flexor forearm. The skin surface temperature and redness were also significantly higher on the cheek in winter. We think that subclinical inflammation resulted in the enhanced turnover rate of the SC associated with elevated TEWL levels observed on the face in winter. In conclusion, the obtained data suggest that the exposed facial skin becomes more irritable under the influence of the dry and cold environment of winter even in healthy individuals where the barrier function of the SC is relatively poor as compared to the skin of other areas.

show abstract

“…En ISAAC I se encontró una relación negativa con el consumo de verduras, proteinas de cereales, frutos secos y pescado fresco (17,18,19), basándo-se en posibles alteraciones dietarias y disponibilidad de araquidonatos en las membranas celulares (20)(21)(22)(23). Este es un cofactor que estamos analizando en conjunto los participantes del estudio ISAAC III.…”

Section: Discusión Y Conclusionesunclassified

La Dermatitis Atópica en Quito y el Ecuador.

Barba¹,

Lascano²,

Naranjo³

et al. 2017

REMCB

View full text Add to dashboard Cite

RESUMEN.-Presentamos los resultados relacionados con la Dermatitis Atópica (DA) del estudio ISAAC III realizado en Quito, Ecuador, en los años 2003 y 2004. El cuestionario internacional valora la presencia de síntomas de eccema en el último año, de eccema diagnosticado, su intensidad y sus relaciones con atopia y el inicio precoz (antes de los 2 años de edad). Encontramos que Quito es una ciudad con alta prevalencia de DA tanto entre los niños de 6 a 7 años de edad como en los adolescentes de 13 a 14 años (95% de confianza, error +/-1.73). Debido a que las formas verdaderamente atópicas, basados en la existencia de fenotipos clínicos de DA, se presentan en el 27% de los niños y en el 7% de los adolescentes, pensamos que hay otros factores que justifican estas prevalencias, como son el clima per-sé, algunas alteraciones medioambientales como la polución, y posibles características genéticas de la barrera física cutánea que permiten sensibilizaciones alérgicas fáciles. PALABRAS CLAVE: Alergia, Dermatitis Atópica, Epidemiología, ISAAC,ABSTRACT.-The results related to Atopic Dermatitis (DA) from ISAAC III studies made in Quito, Ecuador, during the years of 2003 and 2004 are reported in this study. The international questionnaire assesses the presence of symptoms of "current eczema" occurring in the last year, the diagnosed eczema, its intensity and its relationship to atopy, the early onset (before age 2). Quito is a city with high prevalence of DA in both children 6-7, and teens 13-14 years old (95%, error +/-1.73). The atopic phenotype of the disease is present in 27% of children and 7% of teens.

show abstract

Irritant susceptibility and weal and flare reactions to bioactive agents in atopic dermatitis. II. Influence of season

Cited by 44 publications

References 21 publications

Xerotic Skin of the Elderly: A Summer versus Winter Comparison Based on Biophysical Measurements

Xerotic Skin of the Elderly: A Summer versus Winter Comparison Based on Biophysical Measurements

The Winter Season Affects More Severely the Facial Skin than the Forearm Skin: Comparative Biophysical Studies Conducted in the Same Japanese Females in Later Summer and Winter

La Dermatitis Atópica en Quito y el Ecuador.

Contact Info

Product

Resources

About