Irritable bowel syndrome

Birrer, Richard B.

doi:10.1067/mda.2002.122480

Cited by 2 publications

(1 citation statement)

References 159 publications

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“…In the present study, we investigated the possibility of masking the bitterness of trimebutine, a drug used as a treatment for irritable bowel syndrome (Saivin et al 2000 ;Laugier et al 2001 ;Birrer 2002). Trimebutine has an extremely unpleasant bitter taste, reported to be 70± 80 % of the bitterness of quinine, which is the accepted standard for bitterness (Uchida et al 2000).…”

Section: Introductionmentioning

confidence: 98%

Preparation, characterization and taste-masking properties of polyvinylacetal diethylaminoacetate microspheres containing trimebutine

Hashimoto¹,

Tanaka

Kishimoto³

et al. 2002

Journal of Pharmacy and Pharmacology

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The objectives of this study were to produce acid soluble, polyvinylacetal diethylaminoacetate (AEA) microspheres containing trimebutine (as maleate), using a water-in-oil-in-water (w/o/w) emulsion solvent evaporation method, to characterize their in-vitro release properties, and to evaluate the taste-masking potential of this formulation in human volunteers. The pH of the external aqueous phase was the critical factor in achieving a high loading efficiency for trimebutine in the microencapsulation process; nearly 90% (w/w) loading efficiency was obtained at above pH 10. Trimebutine was completely released from AEA microspheres within 10 min in a dissolution test at pH 1.2, simulating conditions in the stomach, whereas at pH 6.8, the pH in the mouth, only small quantities of trimebutine were released in the initial 1-2 min. The results of a gustatory sensation test in healthy volunteers confirmed the taste-masking effects of the AEA microspheres. Finally, an attempt was made to encapsulate the salts of other basic drugs (lidocaine, imipramine, desipramine, amitriptyline, promethazine and chlorpheniramine) into AEA microspheres using the w/o/w emulsion evaporation method. The loading efficiencies were ranked in almost inverse proportion with the solubility of the drugs in the external aqueous phase. This study demonstrated the possibility of masking the taste of salts of basic drugs by microencapsulation with AEA using a w/o/w emulsion solvent evaporation method.

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Section: Introductionmentioning

confidence: 98%

Preparation, characterization and taste-masking properties of polyvinylacetal diethylaminoacetate microspheres containing trimebutine

Hashimoto¹,

Tanaka

Kishimoto³

et al. 2002

Journal of Pharmacy and Pharmacology

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Prevalence of Irritable Bowel Syndrome in College Students and Association With Anxiety, Depression and Fodmap Diet

Jaladi¹,

Vijayaraghavan²,

G³

2015

jebmh

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BACKGROUND: Irritable bowel syndrome (IBS) is the most common functional gastro-intestinal disorder. The data regarding the prevalence of IBS in young adults is limited along with its association with anxiety and depression in a community setting in India. MATERIALS AND METHODS: the prevalence of IBS and its subtypes based on Rome iii criteria were assessed in 2078 college students above 18 years of age along with the prevalence of anxiety and depression based on hospital anxiety depression scale. Frequency of intake of food containing fermentable oligo-di-monosaccharides and polyols (Fodmaps) were obtained. RESULTS:The mean age of the study group is 19.73±1.4 years. The prevalence of IBS is 5.2%, the prevalence in females (6.1%) as compared with males (3.9%). Mixed type of IBS is the most common involving 47.9% of students followed by diarrhea predominant in 22.9%, un subtyped in 17.7% and constipation predominant in 11.5%. The mean anxiety score in students with IBS is 9.61±3.74 as compared to 7.15±3.73 in students without IBS with a p-value of 0.000. The mean depression score as per hads-d in students with IBS is 5.79±3.290 as compared to 4.39±2.942 in students without IBS with a p-value of 0.000. Among students with IBS 48.9% were found to have psychological disorders as compared to 21% without IBS. There was no difference in the intake of food containing fodmaps.

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Irritable bowel syndrome

Cited by 2 publications

References 159 publications

Preparation, characterization and taste-masking properties of polyvinylacetal diethylaminoacetate microspheres containing trimebutine

Preparation, characterization and taste-masking properties of polyvinylacetal diethylaminoacetate microspheres containing trimebutine

Prevalence of Irritable Bowel Syndrome in College Students and Association With Anxiety, Depression and Fodmap Diet

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