Irritable bowel syndrome: the commonest cause of recurrent abdominal pain in children

El‐Matary, Wael; Spray, Christine; Sandhu, Bhupinder

doi:10.1007/s00431-004-1503-0

Cited by 52 publications

(60 citation statements)

References 21 publications

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“…RAP is a symptom based pediatric classification, with at least three attacks of abdominal pain during three consecutive months that interferes with daily activity, which includes a higher percentage of patients who also meet IBS diagnostic criteria. 19,53 In a sample of 21 RAP cases, Dufton, et al 18 found no differences in cold-pressor tolerance or pain intensity, which is consistent with our findings and those of Williams et al cited above. In a small sample including 20 RAP cases, Zohsel, et al found no difference in heat pain threshold or pressure pain threshold between cases and controls.…”

Section: Discussionsupporting

confidence: 92%

“…Thus there is a risk of misclassifying organic diseases as IBS. Still, with the knowledge that most pediatric patients with abdominal pain have functional gastroenterological disorders, 10,30,53 and that IBS is the most common cause, 19 the risk of misclassification is most likely acceptably low if typical symptoms of IBS are present.…”

Section: Discussionmentioning

confidence: 99%

“…19,26,28 IBS is more prevalent among girls than among boys and is associated with high risk of mental health problems and of co-morbid pain at other body sites. 25,26,51 There is broad agreement that IBS is best conceptualized in terms of the biopsychosocial model, with multiple factors contributing to its pathophysiology.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Widespread Hyperalgesia in Adolescents With Symptoms of Irritable Bowel Syndrome: Results From a Large Population-Based Study

Stabell

Stubhaug

Flægstad

et al. 2014

The Journal of Pain

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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Widespread Hyperalgesia in Adolescents With Symptoms of Irritable Bowel Syndrome: Results From a Large Population-Based Study

Stabell

Stubhaug

Flægstad

et al. 2014

The Journal of Pain

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“…1,2 It affects 10-20% of adolescents and adults in western societies 3 and is the commonest cause of recurrent abdominal pain in children. 4 IBS is defined by a symptom complex which includes abdominal pain and altered bowel function in the form of diarrhea, constipation, a sensation of fullness following evacuation, bloating or the passage of mucus per rectum. There are no physical or laboratory findings which are specific for IBS and the diagnosis is therefore based on symptomatology.…”

mentioning

confidence: 99%

Histopathological alterations in irritable bowel syndrome

Kirsch

Riddell

2006

Modern Pathology

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Irritable bowel syndrome is a common disorder defined by a symptom complex including abdominal pain and altered bowel habit. The etiopathogenesis appears to be multifactorial and to involve altered gastrointestinal motor function, enhanced perception of visceral stimuli and psychosocial factors. More recently a role for mucosal immune activation has been suggested. Routine histologic examination reveals no mucosal abnormality in the majority of cases but quantitative histological, immunohistochemical and ultrastructural analyses reveal subtle morphologic changes involving lymphocytes, mast cells, enterochromaffin cells and enteric nerves. The recent appreciation of these changes has led to new hypotheses linking central and enteric nervous systems to immune processes. This review highlights the spectrum of morphologic changes that occur in irritable bowel syndrome, examines their relationship to the pathophysiology of irritable bowel syndrome and considers their relevance to daily pathology practice.

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“…[3][4][5] Avrupa'da çocuklarda fonksiyonel karın ağrısının en sık nedeni olarak irritabl barsak sendromu (İBS) bildirilirken, gelişmekte olan ülkelerde TKA olan çocukların %30'unda organik bir neden saptanmıştır. [6][7][8] Organik nedenler dışlandığında FGİB tanısına yönelinmektedir. Birçok farklı çalışmada, gastrointestinal parazitozlar, inflamatuar barsak hastalığı, çölyak hastalığı, Helicobacter pylori enfeksiyonu, üriner sistem enfeksiyonları, laktoz intoleransı, fruktoz intoleransı ve besin allerjilerinin TKA'ya yol açabilecek organik bir neden olabileceği kabul edilmiş; ancak hangi testin ne zaman, kime uygulanması gerektiği konusunda henüz bir fikir birliğine varılamamıştır.…”

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Recurrent Abdominal Pain in Children: Is it Organic or Functional?

Kırşaçlıoğlu¹,

Kuloğlu²,

Üstündağ³

et al. 2016

Turkiye Klinikleri J Pediatr

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74Çocuklarda Tekrarlayan Karın Ağrısı:Organik mi, Fonksiyonel mi?Ö ÖZ ZE ET T A Am ma aç ç: : Çocuklarda sık görülen bir durum olan tekrarlayan karın ağrısı organik ya da fonksiyonel olabilmektedir. Bu çalışmada, tekrarlayan karın ağrısına yol açan parazitozlar, çöl-yak hastalığı, idrar yolu enfeksiyonu, Helicobacter pylori enfeksiyonu gibi organik nedenlerin değerlendirilmesi ve fonksiyonel gastrointestinal bozuklukların belirlenmesi amaçlanmıştır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışmaya başka bilinen bir hastalığı olmayan ve ilaç kullanmayan, en az üç ay süreyle en az üç kez tekrarlayan karın ağrısı olan çocuklar dâhil edildi. Ağrı karakteri, laboratuvar bulguları, radyolojik incelemeler, histopatolojik bulgular geriye dönük olarak değer-lendirildi. B Bu ul lg gu ul la ar r: : Çalışmaya ortalama yaşı 10,7±3,4 (4-17) yıl olan, ortanca 12 (3-20) aydır tekrarlayan karın ağrısı olan 151 (%57,6'sı kız) hasta alındı. Roma III kriterlerine göre; 81 (%53,6) hastada fonksiyonel gastrointestinal bozukluk, 70 (%46,4) hastada karın ağrısına yol açabilecek organik bir neden saptandı. Fonksiyonel ve organik nedenler arasında yaş, cinsiyet, ağrı süresi ve ağrı özellikleri açısından fark bulunmadı. Fonksiyonel gastrointestinal bozukluklar arasında en sık (%62,9) fonksiyonel karın ağrısı saptandı. Organik nedenli tekrarlayan karın ağrısı olan hastaların %46'sında Helicobacter pylori enfeksiyonu, %10,5'inde dışkıda parazit yumurtası, %3,9'unda biyopsi destekli çölyak hastalığı saptandı. S So on nu uç ç: : Fonksiyonel ve organik karın ağrısının ayırt edilmesinde yaş, cinsiyet, ağrı özellikleri, eşlik eden başka yakınmalar, fizik inceleme bulguları açısından bir fark saptanmamıştır. Çölyak hastalığı, tekrarlayan karın ağrısı olan bütün çocuklarda taranmalıdır.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Çocuk; çölyak hastalığı; karın ağrısı; Helicobacter pylori A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Recurrent abdominal pain is common in childhood, it may be functional or associated with organic disease. Evaluation of organic causes of recurrent abdominal pain such as parasitic enfestations, celiac disease, uriner tract infection, Helicobacter pylori infection and determine functional gastrointestinal disorders in children were aimed in the study. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Children with recurrent abdominal pain more than three times in frequency, for at least three months duration, without a known medical history and drug usage were recruited to study. Medical records were evaluated for pain characteristics, laboratory, radiological and histopathological findings, retrospectively. R Re es su ul lt ts s: : A hundred and fifty-one children [(57.6% female, mean age 10.7±3.4 (4-17) years] with recurrent abdominal pain for median 12 (3-20) months, were recruited to study. According to Rome III criteria; 81 (53.6%) patients had functional gastrointestinal disorders, 70 (46.4%) patients had an organic etiology. There was no difference between function...

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Irritable bowel syndrome: the commonest cause of recurrent abdominal pain in children

Abstract: Of children presenting with recurrent abdominal pain in a hospital setting, 30% have a diagnosable organic aetiology compared to 8% in Apley's time. Irritable bowel syndrome, however, may be the commonest cause of recurrent abdominal pain and should be considered.

Cited by 52 publications

References 21 publications

Widespread Hyperalgesia in Adolescents With Symptoms of Irritable Bowel Syndrome: Results From a Large Population-Based Study

Widespread Hyperalgesia in Adolescents With Symptoms of Irritable Bowel Syndrome: Results From a Large Population-Based Study

Histopathological alterations in irritable bowel syndrome

Recurrent Abdominal Pain in Children: Is it Organic or Functional?

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