Irritable bowel syndrome subtypes: Clinical and psychological features, body mass index and comorbidities

Nagasako, Cristiane Kibune; Montes, Ciro Garcia; Lorena, Sônia Letícia Silva; Mesquita, Márcio

doi:10.17235/reed.2015.3979/2015

Cited by 42 publications

(40 citation statements)

References 33 publications

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“…However, based on clinical experience, patients with IBS-M are more difficult to treat. Other published studies also supported clinical difference in the various IBS-subtypes, with patients with IBS-M subtype posing more difficulties in the management[64-66]. Hence, there is a good chance that the difference observed would be valid.…”

Section: Discussionmentioning

confidence: 76%

Economic burden of irritable bowel syndrome in China

Zhang

Xiang

et al. 2016

WJG

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AIMTo estimate annual direct and indirect costs for patients diagnosed with irritable bowel syndrome (IBS) and subtypes.METHODSPatients completed a standardized questionnaire concerning usage of healthcare resources, travel costs, meals, and productivity loss of patients when seeking treatment for IBS. Total annual costs per patient were calculated as the sum of direct (including medical and nonmedical) and indirect costs. Total annual costs per patient among various IBS subtypes were compared. Analysis of variance and bootstrapped independent sample t-tests were performed to determine differences between groups after controlling for IBS subtypes.RESULTSA total of 105 IBS patients (64.80% female), mean age of 57.12 years ± 10.31 years), mean disease duration of 4.31 years ± 5.40 years, were included. Total annual costs per patient were estimated as CNY18262.84 (USD2933.08). Inpatient and outpatient healthcare use were major cost drivers, accounting for 46.41%and 23.36% of total annual costs, respectively. Productivity loss accounted for 25.32% of total annual costs. The proportions of direct and indirect costs were similar to published studies in other countries. Nationally, the total costs of managing IBS would amount to CNY123.83 billion (USD1.99 billion). Among the IBS subtypes, total annual costs per patient of IBS-M was highest at CNY18891.18 (USD3034). Furthermore, there was significant difference in productivity loss among IBS subtypes (P = 0.031).CONCLUSIONIBS imposes a huge economic burden on patients and healthcare systems, which could account for 3.3% of the total healthcare budget for the entire Chinese nation. More than two-thirds of total annual costs of IBS consist of inpatient and outpatient healthcare use. Among the subtypes, IBS-M patients appear to have the greatest economic burden but require further confirmation.

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Section: Discussionmentioning

confidence: 76%

Economic burden of irritable bowel syndrome in China

Zhang

Xiang

et al. 2016

WJG

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“…Trauma and anxiety-related disorders are major health burdens worldwide, with increased incidence in women relative to men (Altemus et al, 2014). Associated symptoms are highly prevalent in patients with dysbiosis-related syndromes like IBS, which also disproportionately affect women (Kibune-Nagasako et al, 2016;Lovell & Ford, 2012). Our data add to growing evidence for a role of gut microbiota in the pathophysiology of psychiatric conditions (Cowan et al, 2018;Cryan & Dinan, 2012;Kelly et al, 2016;Malan-Muller et al, 2018;MacQueen, Surette, & Moayyedi, 2017), and highlight the need to consider sex as a biological variable (Shansky & Woolley, 2016).…”

Section: Discussionmentioning

confidence: 53%

“…Sex differences in aversive conditioning (Asok, Kandel, & Rayman, 2019;Blume et al, 2017) and gut microbiome structure (Jašarević, Morrison, & Bale, 2016;Markle et al, 2013) have also been reported, albeit inconsistently (Ding & Schloss, 2014;Org et al, 2016). Furthermore, functional bowel disorders like IBS, the most common form, disproportionately affect women (Kibune-Nagasako, García-Montes, Silva-Lorena, & Aparecida-Mesquita, 2016;Lovell & Ford, 2012).…”

Section: Introductionmentioning

confidence: 99%

Sex-specific gut microbiota modulation of aversive conditioning and basolateral amygdala dendritic spine density

Geary

Wilk

Barton

et al. 2020

Preprint

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Gut microbiota influence numerous aspects of host biology, including brain structure and function. Growing evidence implicates gut microbiota in aversive conditioning and anxiety-related behaviors, but research has focused almost exclusively on males. To investigate sex-specific effects of gut dysbiosis on aversive learning and memory, adult female and male C57BL/6N mice were orally administered a moderate dose of non-absorbable antimicrobial medications (ATMs; neomycin, bacitracin, pimaricin) or a control over 10 days. Changes in gut microbiome composition were analyzed by 16S rRNA sequencing. Open field behavior, cued aversive learning, context recall, and cued recall were assessed. Following behavioral testing, the morphology of basolateral amygdala (BLA) principal neuron dendrites and spines was characterized. Results revealed that ATMs induced distinct but overlapping patterns of gut dysbiosis across sex, with stronger effects in females. There were also sex-specific effects on behavior and neuroanatomy. Treated males but not females exhibited altered locomotor and anxiety-like behavior in the novel open field test. Treated females but not males showed impairments in aversive memory acquisition and cued recall. Context recall remained intact in both sexes, as did dendritic structure of BLA principal neurons. However, ATMs exerted sex-specific effects on spine density. A second experiment was conducted to isolate gut perturbation to cued recall. Results revealed no effect of ATMs on recall of a previously consolidated fear memory, suggesting that gut dysbiosis preferentially impacts aversive learning. These data shed new light on how gut microbiota interact with sex to influence aversive conditioning, anxiety-like behavior, and BLA dendritic spine architecture.SignificanceGut microbiota can influence brain function and behavior, including trauma and anxiety-related disorders. Although these disorders disproportionately affect women, preclinical research has focused almost exclusively on male rodent models. We investigated the impact of antimicrobial administration on gut microbiome structure, aversive conditioning, open field behavior, and basolateral amygdala principal neuron morphology in female and male mice. Results showed that treatment exerted wide-ranging effects, many of which were sex-specific. Our findings underscore the importance of studying sex differences and support a role for microbial modulation of aversive learning, anxiety-like behavior, and amygdala spine patterning.

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“…We chose the above covariates because they may be associated with dietary restrictions and gastrointestinal symptoms like irritable bowel syndrome. [9][10][11][12] All tests were two-tailed with a significance level set at p<0.05. The data were analysed with STATA V.12.…”

Section: Methodsmentioning

confidence: 99%

Coeliac disease: no difference in milk and dairy products consumption in comparison with controls

Zingone

Iovino

Bucci

et al. 2019

BMJNPH

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BackgroundNutritional deficiencies are common in patients with coeliac disease and they can cause osteopenia among other associated diseases. Reduced consumption of milk and dairy products may play a major role in determining low bone mass in patients with coeliac disease.AimWe aimed to investigate milk and dairy products consumption in patients with coeliac disease compared with the general population.MethodsWe examined the average consumption of milk and dairy products and the reasons for not consuming them. An online survey was sent by email to patients with coeliac disease on a gluten-free diet and aged 18–75. Matched controls were selected among volunteers who responded to the survey posted on the public access sites. Differences in frequencies and means between the two groups were calculated using the χ2 test and t-test, respectively. All tests were two-tailed with a significance level set at p<0.05.Results176 patients with coeliac disease and 528 controls participated in the study. We found that 22.2% of the patients with coeliac disease and 19.9% of controls did not drink fluid milk on a regular basis; lactose-free milk was preferred by 20.4% of the patients with coeliac disease and by 19% of controls (p=0.69). Only a minority of patients with coeliac disease contacted a doctor before having lactose-free milk, despite this being led by the presence of gastrointestinal symptoms. More patients with coeliac disease than the general population reported a breath test before avoiding milk and dairy products.ConclusionsThere is no significant difference between patients with coeliac disease and controls in regular milk consumption. Follow-up visits for patients with coeliac disease could avoid unnecessary dietary restrictions.

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Irritable bowel syndrome subtypes: Clinical and psychological features, body mass index and comorbidities

Abstract: Background: Irritable bowel syndrome (IBS) is classified into subtypes according to bowel habit.Objective: To investigate whether there are differences in clinical features, comorbidities, anxiety, depression and body mass index (BMI) among IBS subtypes.

Cited by 42 publications

References 33 publications

Economic burden of irritable bowel syndrome in China

Economic burden of irritable bowel syndrome in China

Sex-specific gut microbiota modulation of aversive conditioning and basolateral amygdala dendritic spine density

Coeliac disease: no difference in milk and dairy products consumption in comparison with controls

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