Irritable Bowel Syndrome Prevalence Varies Enormously Depending on the Employed Diagnostic Criteria: Comparison of Rome II Versus Previous Criteria in a General Population

Mearin, Fermı́n; Badı́a, Xavier; Balboa, Agustín; Baró, Eva; Caldwell, Ellen; Cucala, Mercedes; Dı́az-Rubio, Manuel; Fueyo, Arturo; Ponce, Julio; Roset, Montse; Talley, NJ

doi:10.1080/00365520152584770

Cited by 204 publications

(33 citation statements)

References 17 publications

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“…Epidemiological studies on functional gastrointestinal disorders, for instance IBS, are hampered by the varying diagnostic criteria used [1, 6, 7]. This was highlighted in a recent study in which huge differences in the prevalence rates of IBS were found depending the definition of IBS [8]. Another potential drawback of some of the existing epidemiological studies relates to possible selection bias, due to not using random samples from society, obtaining low response rates, or due to the way the questionnaire is administered.…”

Section: Introductionmentioning

confidence: 99%

Quality of Life and Illness Costs in Irritable Bowel Syndrome

et al. 2004

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Quality of life is reduced in patients with irritable bowel syndrome, and the costs for this disease are substantial to society. During a meeting in London, UK, the IBiS club reviewed the literature on these subjects. Drawbacks and advantages with existing instruments to assess quality of life and costs were discussed and the clinical and scientific relevance of the current knowledge was assessed. A summary from the meeting is presented in this paper.

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Section: Introductionmentioning

confidence: 99%

Quality of Life and Illness Costs in Irritable Bowel Syndrome

et al. 2004

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“…By applying the Rome I and Rome II diagnostic criteria and analyzing the studies conducted in western countries in the general population, the prevalence of IBS is seen to vary between 3.3 and 13.6% [13,14,15,16]. Functional abdominal bloating occurs in approximately 15% of community-based populations [11, 17], and appears to be more frequent in females than males.…”

Section: Magnitude Of the Problem: How Relevant Are Functional Digestmentioning

confidence: 99%

“…1 IBS prevalence varies enormously depending of the criteria employed for diagnosis (from Mearin et al [14]). …”

Section: Magnitude Of the Problem: How Relevant Are Functional Digestmentioning

confidence: 99%

“…It has been observed that Rome II criteria are too restrictive in clinical practice though useful to select patients for clinical trials. In our own experience, more than two thirds of subjects meeting Manning or Rome I criteria would not be diagnosed as having IBS if Rome II criteria were employed [14]. …”

Section: Magnitude Of the Problem: How Relevant Are Functional Digestmentioning

confidence: 99%

“…Estimated IBS prevalence depends very much on the diagnostic criteria applied to define the syndrome [14 ](fig. 1).…”

Section: Magnitude Of the Problem: How Relevant Are Functional Digestmentioning

confidence: 99%

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Pharmacological Treatment of the Irritable Bowel Syndrome and Other Functional Bowel Disorders

Mearin

2006

Digestion

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Functional digestive disorders constitute one of the main causes of consultation in gastroenterology and primary health care. Is still unclear whether therapy has to be aimed to the gut, to the neural pathways controlling bowel motility and perception, or to the processing mechanisms of symptoms and disease behaviour. It is conceivable that in the next future better understanding of functional bowel disorders pathophysiology will help us to tailor treatment for different patients. At the moment, subclassification of the diverse patterns of symptomatology allows to adjust new treatments for irritable bowel syndrome (IBS) according to the clinical predominance for each patient. The knowledge of motor and sensorial response to different stimuli in IBS patients and the pathways to the central nervous system is an important source of information for the development of new molecules. Fiber-enriched diet is frequently given for constipation-predominant IBS. Loperamide, antispasmodic drugs and tricyclic antidepressants are nowadays the basis for pharmacological treatment of diarrhea- predominant IBS. The scientific evidence supporting this therapeutical approach is however limited. Visceral analgesics and serotonin agonists and antagonists may play an important therapeutical role in the near future. However, it is not likely that one single treatment will help every functional bowel disorder patient and many of them will need a more complex approach with a multidisciplinary therapy (diet, psychotherapy, medications).

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