Irritable bowel syndrome in China: a review on the epidemiology, diagnosis, and management

Liu, Yilin; Liu, Jinsong

doi:10.1097/cm9.0000000000001550

Cited by 19 publications

(6 citation statements)

References 36 publications

(67 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Irritable bowel syndrome with diarrhea (IBS-D), a subtype of IBS characterized by abdominal discomfort and frequent defection, is the most prevalent functional gastrointestinal disorder (FGID) both in China and globally ( Liu and Liu, 2021 ; Sperber et al, 2021 ). Anti-diarrheal medications such as anticholinergics, mu-opioid agonists, and serotonin receptor antagonists are still widely used in IBS-D therapy but have mixed efficacy and can cause side effects ( Camilleri and Andresen, 2009 ).…”

Section: Introductionmentioning

confidence: 99%

Aqueous cinnamon extract ameliorates bowel dysfunction and enteric 5-HT synthesis in IBS rats

Huang²,

Yang³

et al. 2023

Front. Pharmacol.

View full text Add to dashboard Cite

Cinnamon protects against irritable bowel syndrome with diarrhea (IBS-D) in humans, but its efficacy and underlying mechanism of action remain poorly understood. Maternally separated (MS) IBS-D rat model and 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced post-inflammatory IBS-D rat model are characterized by visceral hyperalgesia and diarrhea. This study used the two models to evaluate the effect of cinnamon extract (CE) on bowel symptoms. The MS rat model was also used to explore its underlying anti-IBS mechanism. cinnamon extract reduced defecation frequency and visceral hyperalgesia in MS rats in a dose-dependent manner and effectively improved visceral hyperalgesia in TNBS rats. The efficacy of cinnamon extract was comparable to the positive drug serotonin receptor 3 (5-HT3) selective antagonist, Ramosetron. Excessive 5-HT, a well-known pathogenic factor for IBS, in the colon and circulation of IBS rats was reduced after cinnamon extract intervention. Both, gene and protein levels of the colonic 5-HT synthetase, Tryptophan Hydroxylase 1 (Tph1), were also decreased in CE-treated IBS rats. In addition, a luciferase assay revealed that cinnamon extract and its major components, catechin, procyanidin B1/2, cinnamic acid, and cinnamyl alcohol, significantly inhibited Tph1 transcription activity in vitro. These findings illustrated that aqueous cinnamon extract partially attenuated bowel symptoms in IBS models by directly inhibiting Tph1 expression and controlling 5-HT synthesis. This provides a scientific viewpoint for the use of cinnamon as a folk medication to treat IBS.

show abstract

Section: Introductionmentioning

confidence: 99%

Aqueous cinnamon extract ameliorates bowel dysfunction and enteric 5-HT synthesis in IBS rats

Huang²,

Yang³

et al. 2023

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…However, heterogeneity depending on cities (3.2% in Xi’an, 5.9% in Hangzhou, 7.6% in Changzhou, and 15.8% in Shanghai) was observed. 25 A meta-analysis suggested that a history of acute gastrointestinal infection, food allergies, alcohol consumption, and anxiety/depression were significant IBS risk factors among the Chinese. 26 Whether our observation of low IBS prevalence in Beijing was due to regional heterogeneity or some underlying factors is uncertain.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Irritable Bowel Syndrome in Japan, China, and South Korea: An International Cross-sectional Study

Takeoka

Kimura

Hara

et al. 2023

J Neurogastroenterol Motil

View full text Add to dashboard Cite

Background/AimsSymptoms of irritable bowel syndrome (IBS), a common gut-brain interaction disorder, deteriorate patients' quality of life and increase medical needs; therefore, IBS represents a significant global burden. The estimated global prevalence is approximately 10%; however, accumulated evidence shows international heterogeneity. In this study, we have described and compared the prevalence of IBS in 3 East Asian countries: Japan (Tokyo and Fukuoka), China (Beijing), and South Korea (Seoul). MethodsWe conducted an internet-based cross-sectional survey of the urban population aged > 20 years in the abovementioned countries. We recruited equal numbers of age-(20s-60s) and sex-matched participants (3910 residents). IBS was diagnosed according to the Rome III criteria, and the subtypes were analyzed. ResultsThe overall prevalence of IBS with 95% CI was 12.6% (11.6-13.7); the prevalence was significantly different across Japan, China,, respectively) (P < 0.001). Furthermore, 54.9% of patients were male. IBS-mixed was the most prevalent subtype; the prevalence of other subtypes varied. ConclusionsThe overall prevalence of IBS in the 3 countries was slightly higher than the global prevalence, and it was significantly lower in China than in Japan and South Korea. IBS prevalence was the highest and lowest among individuals in their 40s and 60s, respectively. Male individuals had a higher prevalence of IBS with diarrhea. Further studies are needed to elucidate the factors associated with this regional heterogeneity.

show abstract

“…Considering the differences in survey samples and survey criteria, multiple research studies have shown that the incidence of IBS in China varied from 4.5% to 12.7%. [7][8][9] As early as 2013, a study showed that the direct medical expenses for an IBS patient in the United States could reach up to US$7547 per year. [10] In China, the total annual medical service cost for IBS patients was US$2 RHW and YKL contributed equally to this work.…”

Section: Introductionmentioning

confidence: 99%

Exploring the synergistic pharmacological mechanism of Huoxiang Drink against irritable bowel syndrome by integrated data mining and network pharmacology

Wang,

Lin,

Xie

et al. 2023

Medicine

View full text Add to dashboard Cite

Irritable bowel syndrome (IBS) is the most common functional gastrointestinal disorder, characterized by abdominal pain, bloating, and changes in bowel habits. Huoxiang Drink (HD), derived from traditional Chinese medicine, has been reported to effectively treat digestive disorders caused by external cold and internal dampness. However, the pharmaceutical targets and mechanisms for HD against IBS remain unclear. Data mining, bioinformatics analysis, and network pharmacology were employed to explore the potential pharmacological mechanisms of HD against IBS. In this study, we screened 50 core targets to investigate the pharmacological mechanisms of HD against IBS. Enrichment analysis revealed that HD may participate in various signaling pathways, especially the inflammation-related tumor necrosis factor, signaling pathway and hypoxia-inducible factor signaling pathway. Molecular docking results confirmed that MOL000098 (Quercetin), MOL000006 (Luteolin), MOL005828 (Nobiletin), MOL005916 (Irisolidone), and MOL004328 (Naringenin), as key active ingredients in HD, bound to core targets (tumor protein P53, tumor necrosis factor, matrix metalloproteinases 9, and vascular endothelial growth factor-A) for topical treatment of IBS. This study suggested that HD offered a potential therapeutic strategy against IBS. Our findings may facilitate the efficient screening of active ingredients in HD and provide a theoretical basis for further validating the clinical therapeutic effects of HD on treating IBS.

show abstract

Irritable bowel syndrome in China: a review on the epidemiology, diagnosis, and management

Cited by 19 publications

References 36 publications

Aqueous cinnamon extract ameliorates bowel dysfunction and enteric 5-HT synthesis in IBS rats

Aqueous cinnamon extract ameliorates bowel dysfunction and enteric 5-HT synthesis in IBS rats

Prevalence of Irritable Bowel Syndrome in Japan, China, and South Korea: An International Cross-sectional Study

Exploring the synergistic pharmacological mechanism of Huoxiang Drink against irritable bowel syndrome by integrated data mining and network pharmacology

Contact Info

Product

Resources

About