Irritable bowel syndrome, gastro-oesophageal reflux disease and dyspepsia: Overlap analysis using loglinear models

Pourhoseingholi, Asma; Vahedi, Mohsen; Pourhoseingholi, Mohamad Amin; Ashtari, Sara; Moghimi-Dehkordi, Bijan; Safaee, Azadeh; Zali, Mohammad Reza

doi:10.1016/j.ajg.2012.02.005

Cited by 17 publications

(22 citation statements)

References 28 publications

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“…Previous studies have suggested that an overlap between GERD and IBS is more common than expected by chance. 4,6,[10][11][12][13] However, most of these studies evaluated this condition only in selected individuals, rather than in the general population. A systematic review has shown that IBS accompanied by GERD is more common in selected patients than in non-patients.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, these diseases may have more in common than previously assumed and may interact with each other. Studies have shown that GERD and IBS often coexist, with a prevalence of IBS in GERD of up to 70% . However, most studies are based on outpatient observations and are limited to the overlap of GERD and IBS .…”

Section: Introductionmentioning

confidence: 99%

“…Studies have shown that GERD and IBS often coexist, with a prevalence of IBS in GERD of up to 70%. 6,7 However, most studies are based on outpatient observations and are limited to the overlap of GERD and IBS. 8 There are few population-based studies available, especially from the residents of rural areas, and the epidemiological data on GERD and FGID in Chinese is rare.…”

Section: Introductionmentioning

confidence: 99%

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Overlap of gastroesophageal reflux disease and functional bowel disorders in the general Chinese rural population

Cai

Wang

et al. 2015

J of Digest Diseases

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Overlap of gastroesophageal reflux disease and functional bowel disorders in the general Chinese rural population

Cai

Wang

et al. 2015

J of Digest Diseases

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“…The underlying mechanism remains unclear. However, some studies have shown that gastroesophageal reflux disease overlapped, to some extent, with IBS and dyspepsia …”

Section: Discussionmentioning

confidence: 99%

The spectra, symptom profiles and overlap of Rome III functional gastrointestinal disorders in a tertiary center in South China

Xiong

Shi

Gong

et al. 2014

J of Digest Diseases

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“…Somatostatin inhibits acid secretion directly by acting on parietal cells and indirectly by inhibiting histamine and gastrin secretion (47–51). The present findings of increased gastrin and decreased somatostatin in all IBS subtypes may cause a high level of gastric acid secretion, which may account for the high incidence of dyspepsia and gastro-oesophageal reflux observed in patients with IBS (53–61). …”

Section: Discussionmentioning

confidence: 54%

Stomach antral endocrine cells in patients with irritable bowel syndrome

Gilja

Hatlebakk

Hausken

2014

International Journal of Molecular Medicine

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To the best of our knowledge, stomach antral endocrine cells have not previously been investigated in patients with irritable bowel syndrome (IBS). Thus, in the present study, 76 patients with IBS were examined (designated as IBS-total). Diarrhoea was the predominant symptom in 26 of these patients (IBS-D), while in 21 patients, the predominant symptoms were both diarrhoea and constipation (IBS-M) and in 29 patients the predominant symptom was constipation (IBS-C). Forty-three healthy subjects were enrolled as the controls. Stomach antral biopsy samples obtained from all of the subjects were immunostained using the avidin-biotin-complex method for serotonin, gastrin, somatostatin and serotonin transporter (SERT). The immunopositive cell densities and immunoreactivity intensities were determined by computer-aided image analysis. The density of the serotonin-immunoreactive cells was significantly decreased in the IBS-M patients and increased in the IBS-C patients relative to the controls. The immunoreactivity intensity did not differ significantly between the controls and IBS-total. The density of the gastrin-immunoreactive cells was significantly greater in the IBS-D, IBS-M and IBS-C patients than in the controls. The immunoreactivity intensity of gastrin was significantly greater in the IBS-D patients than in the controls. The density of the somatostatin-immunoreactive cells cells was significantly lower in the IBS-total, IBS-D, IBS-M and IBS-C patients than in the controls. The immunoreactivity intensities of both somatostatin and SERT did not differ significantly between the controls and IBS-total. The increase in gastrin cell density and the decrease in somatostatin cell density in all IBS subtypes may cause high levels of gastric secretion, which may in turn contribute to the high incidence of dyspepsia and gastro-oesophageal reflux observed in patients with IBS.

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Irritable bowel syndrome, gastro-oesophageal reflux disease and dyspepsia: Overlap analysis using loglinear models

Cited by 17 publications

References 28 publications

Overlap of gastroesophageal reflux disease and functional bowel disorders in the general Chinese rural population

Overlap of gastroesophageal reflux disease and functional bowel disorders in the general Chinese rural population

The spectra, symptom profiles and overlap of Rome III functional gastrointestinal disorders in a tertiary center in South China

Stomach antral endocrine cells in patients with irritable bowel syndrome

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