Irritable Bowel Syndrome and Gastroesophageal Reflux Disease in Primary Care: Is There a Link?

Ruigómez, Ana; Wallander, Mari‐Ann; Johansson, Saga; Rodrı́guez, Luis A. Garcı́a

doi:10.1007/s10620-008-0462-0

Cited by 17 publications

(19 citation statements)

References 48 publications

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“…The current results support an association of GERD with a history of peptic ulcer disease [16,35-37], but do not support associations seen in Europe between GERD and irritable bowel syndrome or asthma [36,38,39] or a protective effect for gastritis against GERD [40]. It is, however, important to distinguish between objectively demonstrated gastritis and the patient-reported history of gastritis that is reported in the present study.…”

Section: Discussioncontrasting

confidence: 75%

A population-based survey of the epidemiology of symptom-defined gastroesophageal reflux disease: the Systematic Investigation of Gastrointestinal Diseases in China

Zhao

et al. 2010

BMC Gastroenterol

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BackgroundThe epidemiology of gastroesophageal reflux disease (GERD) has yet to be investigated using the symptomatic threshold criteria recommended by the Montreal Definition. This study aimed to determine the prevalence of symptom-defined GERD across five regions of China, and to investigate variables associated with GERD.MethodsA representative sample of 18 000 adults (aged 18-80 years) were selected equally from rural and urban areas in each region (n = 1800). According to the Montreal Definition, GERD is present when mild symptoms of heartburn and/or regurgitation occur on ≥2 days a week, or moderate-to-severe symptoms of heartburn and/or regurgitation occur on ≥1 day a week.ResultsIn total, 16 091 participants completed the survey (response rate: 89.4%) and 16 078 responses were suitable for analysis. Applying the Montreal criteria, the prevalence of symptom-defined GERD was 3.1% and varied significantly (p < 0.001) among the five regions (from 1.7% in Guangzhou to 5.1% in Wuhan) and between rural and urban populations (3.8% vs 2.4%). Factors significantly associated with GERD included living in a rural area and a family history of gastrointestinal diseases.ConclusionsThis population-based survey found that the prevalence of symptom-defined GERD in China was 3.1%, which is lower than that found in Western countries.

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Section: Discussioncontrasting

confidence: 75%

A population-based survey of the epidemiology of symptom-defined gastroesophageal reflux disease: the Systematic Investigation of Gastrointestinal Diseases in China

Zhao

et al. 2010

BMC Gastroenterol

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“…The same may be true for anxiety and depression (preliminary evidence is provided in Table 5 and it appears these psychological variables are relevant whether or not there is gastroenteritis; they are not merely a predisposing factor exacerbating the effect of gastroenteritis. 27,33,34 Other functional gastrointestinal disorders, such as dyspepsia and GERD, together with pain and sleep disorders have been shown to be very closely associated with IBS and might share a common aetiological pathway. 27,33,34 Other functional gastrointestinal disorders, such as dyspepsia and GERD, together with pain and sleep disorders have been shown to be very closely associated with IBS and might share a common aetiological pathway.…”

Section: Breadth and Strength Of Risk Factorsmentioning

confidence: 99%

Review article: the incidence and risk factors for irritable bowel syndrome in population‐based studies

Creed

2019

Aliment Pharmacol Ther

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Background:In the absence of prior gastrointestinal infection, the risk factors for irritable bowel syndrome (IBS) are not well established.Aim: To identify the incidence and risk factors for IBS in general population samples Methods: Narrative review of population-based studies. Electronic databases were searched using the keywords "incidence," "onset," "epidemiology," "population," "risk factors" with "irritable bowel syndrome" with subsequent hand searching. Inclusion criteria were: population-based, adults, prospective design (including retrospective case cohorts), clinical or research diagnosis of IBS and exclusion of individuals who had IBS prior to recruitment. Results:Of 1963 papers, 38 were included; all provided data on risk factors, 27 reported incidence. The median incidence of physician-diagnosed IBS in 19 general population cohorts was 38.5 per 10 000 person-years (interquartile range = 20-45.3).In 14 cohorts with specific medical disorders, median incidence was 92 per 10 000 person-years (IQR: 73.9-119). Apart from gastroenteritis, the most common risk factors were other medical disorders, female sex, age (both young and old), anxiety and depression, life events/stress, frequent healthcare use, pain and sleep disorders. The results were conflicting for alcohol consumption, smoking and BMI. Incidence rates were similar in different countries but risk factors differed.Conclusions: Incidence rates were generally lower than previous estimates reflecting physician-diagnosed IBS. The results highlight the importance of other medical and psychosocial problems in the onset of IBS in addition to prior gastrointestinal infections. Aetiological research could be enhanced by studying the underlying mechanisms relating to all of these risk factors.

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“…These drugs include the anticholinergics, calcium-channel blockers, benzodiazepines, and dopamine [5]. Additional risk factors that have been identified in adults are alcohol consumption, smoking, connective tissue diseases (particularly scleroderma) [6], and chronic obstructive pulmonary disease [7]. …”

Section: Incidencementioning

confidence: 99%

Gastroesophageal Reflux in Critically Ill Children: A Review

Solana

Cid

Sánchez

2013

ISRN Gastroenterology

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Gastroesophageal reflux (GER) is very common in children due to immaturity of the antireflux barrier. In critically ill patients there is also a high incidence due to a partial or complete loss of pressure of the lower esophageal sphincter though other factors, such as the use of nasogastric tubes, treatment with adrenergic agonists, bronchodilators, or opiates and mechanical ventilation, can further increase the risk of GER. Vomiting and regurgitation are the most common manifestations in infants and are considered pathological when they have repercussions on the nutritional status. In critically ill children, damage to the esophageal mucosa predisposes to digestive tract hemorrhage and nosocomial pneumonia secondary to repeated microaspiration. GER is mainly alkaline in children, as is also the case in critically ill pediatric patients. pH-metry combined with multichannel intraluminal impedance is therefore the technique of choice for diagnosis. The proton pump inhibitors are the drugs of choice for the treatment of GER because they have a greater effect, longer duration of action, and a good safety profile.

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Irritable Bowel Syndrome and Gastroesophageal Reflux Disease in Primary Care: Is There a Link?

Cited by 17 publications

References 48 publications

A population-based survey of the epidemiology of symptom-defined gastroesophageal reflux disease: the Systematic Investigation of Gastrointestinal Diseases in China

A population-based survey of the epidemiology of symptom-defined gastroesophageal reflux disease: the Systematic Investigation of Gastrointestinal Diseases in China

Review article: the incidence and risk factors for irritable bowel syndrome in population‐based studies

Gastroesophageal Reflux in Critically Ill Children: A Review

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