Irritable bowel syndrome

Enck, Paul; Aziz, Qasim; Barbara, Giovanni; Farmer, Adam D.; Fukudo, Shin; Mayer, Emeran A.; Niesler, Beate; Quigley, Eamonn M.M.; Rajilić‐Stojanović, Mirjana; Schemann, Michael; Schwille‐Kiuntke, Juliane; Simrén, Magnus; Zipfel, Stephan; Spiller, Robin C.

doi:10.1038/nrdp.2016.14

Cited by 761 publications

(913 citation statements)

References 250 publications

(308 reference statements)

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“…[50] Given the affective role of the amygdala in pain perception, it is unsurprising that this region has also been implicated in irritable bowel syndrome (IBS), a disorder associated with microbiota alterations [51] and characterized by gastrointestinal discomfort, visceral pain, and frequent comorbidity with affective dysfunction. [52] IBS patients exhibit hyperactivity in the amygdala and connected brain regions both at baseline and in response to visceral stimulation. [53,54] In some studies at least, sex and genetic differences have been identified in IBS-induced amygdala hyperactivity, and stronger effects are observed in males [55] and those with a particular polymorphism of the serotonin receptor gene, HTR3A.…”

Section: Amygdala Regulates Affective Responses In Pain and Irritablementioning

confidence: 99%

Gutsy Moves: The Amygdala as a Critical Node in Microbiota to Brain Signaling

et al. 2017

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The amygdala is a key brain area regulating responses to stress and emotional stimuli, so improving our understanding of how it is regulated could offer novel strategies for treating disturbances in emotion regulation. As we review here, a growing body of evidence indicates that the gut microbiota may contribute to a range of amygdala-dependent brain functions from pain sensitivity to social behavior, emotion regulation, and therefore, psychiatric health. In addition, it appears that the microbiota is necessary for normal development of the amygdala at both the structural and functional levels. While further investigations are needed to elucidate the exact mechanisms of microbiota-to-amygdala communication, ultimately, this work raises the intriguing possibility that the gut microbiota may become a viable treatment target in disorders associated with amygdala dysregulation, including visceral pain, post-traumatic stress disorder, and beyond. Also see the video abstract here: https://youtu.be/O5gvxVJjX18

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Section: Amygdala Regulates Affective Responses In Pain and Irritablementioning

confidence: 99%

Gutsy Moves: The Amygdala as a Critical Node in Microbiota to Brain Signaling

et al. 2017

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“…It is the most frequently diagnosed type of the FGIDs, and the commonest reason for visiting gastroenterologist [1,2]. The condition is manifested by alteration of bowel habits (diarrhoea and constipation), abdominal pain and bloating, in absence of chemical or pathological disorders and other red flags.…”

Section: Introductionmentioning

confidence: 99%

Irritable bowel syndrome among paramedical students, King Abdulaziz University, Jeddah, Saudi Arabia

Ibrahim¹,

Al-Jamhoor²,

Ashour³

et al. 2018

Gastroenterol Hepatol Endosc

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Aim: The study was done to determine the prevalence and associated factors of IBS among paramedical students at King Abdulaziz University, Jeddah, Saudi Arabia. Methods:A cross-sectional study was done during 2016/2017 at the Faculty of Health Sciences, King Abdulaziz University, Jeddah. A multistage stratified random sample method was used to select 525 paramedical students. A standardized self-administered data collection sheet was used and contained the validated scales of Rome III Criteria, Hospital Anxiety and Depression Scale (HADS) and Pittsburgh Sleep Quality Index (PSQI).Results: One-third of the paramedical students met the Rome-III criteria of IBS. Nursing and dentistry students had higher IBS prevalence compared to others. IBS-Mixed and IBS-Constipation were the commonest sub-types. IBS was associated with female gender, educational specialty, family history of IBS, family income, chronic medical conditions, food hypersensitivity, traveler's diarrhea, poor sleep quality, stress, anxiety, and depression. Regression analysis revealed that female gender (aOR: 1.83; 95% CI: 1.12-3.28), stress, depression, IBS family history and poor sleeping were IBS predictors after controlling of confounding factors. Conclusion:The prevalence of IBS was high among paramedical students, and it was predicted by gender, stress, depression, poor sleeping, and family history. Screening for IBS and psychological problems, stress management courses and IBS educational programs are recommended for paramedical students.

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“…Studies undertaken in the United States of America and Chile have demonstrated that young adults with IBS have a worse HRQL than older adults with this condition, with female patients the most affected (17,18). IBS has a great economic impact in terms of health and work, as its symptoms can interfere with social and work life, affecting the HRQL of sufferers (19,20), with even the families of IBS patients presenting higher levels of stress which are comparable to those of caregivers of people with dementia (21).…”

Section: Introductionmentioning

confidence: 99%

Health-related quality of life in adults with irritable bowel syndrome in a Mexican specialist hospital. A cross-sectional study

et al. 2017

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Background: Evidence shows the negative impact of irritable bowel syndrome on the quality of life of patients who suffer from the condition as compared to the general population.Objective: The objective of this study was to determine the health-related quality of life in adults with irritable bowel syndrome who are receiving treatment at a specialist hospital.Material and methods: The study had a cross-sectional prospective design. The study included consecutive patients diagnosed with irritable bowel syndrome under the Rome III criteria and attending outpatient appointments. The SF-36 questionnaire was applied in its standard Spanish version and the results were compared with population reference scores in Mexico. Statistical analysis was performed with the Student's t test, analysis of variance and the Chi-squared test, considering a significance of 0.05%.Results: One hundred and fifty-four patients were included in the study, 137 (89%) women and 17 (11%) men, with an average age of 52.8 (SD 12.6). The constipation, diarrhea and mixed subtypes comprised 85 (55.2%), 27 (17.5%) and 42 (27.3%) patients, respectively. The quality of life of patients with irritable bowel syndrome vs the population reference scores in Mexico were 50 vs 79 for the physical health sub-scale and 59.1 vs 76.7 for the mental health sub-scale, respectively (p = 0.000). No significant difference was found in quality of life among the irritable bowel syndrome subtypes (p > 0.05).Conclusions: Health-related quality of life is lower in patients with irritable bowel syndrome in a population in the North East of Mexico compared to the data taken from a population reference study undertaken in the same country, enabling an inference in the female population and a cautious one from the results found in the small male sample studied. There was no significant difference found in the quality of life according to the clinical subtype of irritable bowel syndrome.

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Irritable bowel syndrome

Cited by 761 publications

References 250 publications

Gutsy Moves: The Amygdala as a Critical Node in Microbiota to Brain Signaling

Gutsy Moves: The Amygdala as a Critical Node in Microbiota to Brain Signaling

Irritable bowel syndrome among paramedical students, King Abdulaziz University, Jeddah, Saudi Arabia

Health-related quality of life in adults with irritable bowel syndrome in a Mexican specialist hospital. A cross-sectional study

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