Irritability in Mood Disorders: Neurobiological Underpinnings and Implications for Pharmacological Intervention

Bell, Erica; Boyce, Phillip; Porter, Richard; Bryant, Richard A.; Malhi, Gin S

doi:10.1007/s40263-021-00823-y

Cited by 21 publications

(23 citation statements)

References 122 publications

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“…A6 “Irritable” was positively correlated with D5 “Appetite changes” and D7 “Concentration difficulties.” Irritability represents an increased tendency to anger relative to peers ( 69 ), and a change in food intake can be a way to vent anger. Irritability is frequently comorbid with attention-deficit/hyperactivity disorder ( 70 ), and the impairments and dysfunction in individuals with irritability may be partially caused by concentration difficulties ( 71 ).…”

Section: Discussionmentioning

confidence: 99%

Network analysis of anxiety and depression in the functionally impaired elderly

Yang

Guo

Cao

et al. 2022

Front. Public Health

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BackgroundEvidence from previous studies has confirmed that functionally impaired elderly individuals are susceptible to comorbid anxiety and depression. Network theory holds that the comorbidity emerges from interactions between anxiety and depression symptoms. This study aimed to investigate the fine-grained relationships among anxiety and depression symptoms in the functionally impaired elderly and identify central and bridge symptoms to provide potential targets for intervention of these two comorbid disorders.MethodsA total of 325 functionally impaired elderly individuals from five communities in Xi'an, China, were recruited for our investigation. The GAD-7 and PHQ-9 were used to measure anxiety and depression, respectively. SPSS 22.0 software was used for descriptive statistics, and R 4.1.1 software was used for network model construction, expected influence (EI) evaluation and bridge expected influence (BEI) evaluation.ResultsIn the network, there were 35 edges (indicating partial correlations between symptoms) across the communities of anxiety and depression, among which the strongest edge was A1 “Nervousness or anxiety”-D2 “Depressed or sad mood.” A2 “Uncontrollable worry” and D2 “Depressed or sad mood” had the highest EI values in the network, while A6 “Irritable” and D7 “Concentration difficulties” had the highest BEI values of their respective community. In the flow network, the strongest direct edge of D9 “Thoughts of death” was with D6 “Feeling of worthlessness.”ConclusionComplex fine-grained relationships exist between anxiety and depression in functionally impaired elderly individuals. “Uncontrollable worry,” “depressed or sad mood,” “irritable” and “concentration difficulties” are identified as the potential targets for intervention of anxiety and depression. Our study emphasizes the necessity of suicide prevention for functionally impaired elderly individuals, and the symptom “feeling of worthlessness” can be used as an effective target.

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Section: Discussionmentioning

confidence: 99%

Network analysis of anxiety and depression in the functionally impaired elderly

Yang

Guo

Cao

et al. 2022

Front. Public Health

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“…To reach this conclusion, they appear to have drawn selectively from an external, non-peer-reviewed evaluation conducted by EY in 2020. 2 While there are several obvious errors in the EY report (e.g. case-load calculations [personal communication, 13 July 2022]), the most serious misrepresentation relates to economics.…”

Section: Disclosurementioning

confidence: 99%

Response to Allison et al. (2022) ‘Headspace early intervention for psychosis in Australia: Is it still a “best buy”?’

Brown

Killackey

Hamilton

et al. 2023

Australas Psychiatry

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“…In this study, 1 for example, major depressive disorder (MDD) is widely recognized as a heterogeneous illness, and this would be even more likely in the patients described, given the naturalistic recruitment from treatment centres. Irritability itself, as we have pointed out 2 and the authors acknowledge, is variably characterized and in need of precise definition.…”

mentioning

confidence: 91%